DegronMD - Q9UF11(PLEKHB1)

PLEKHB1

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S11Y	TCGA-KL-8335	KICH	TCGA	SPAAPVPPD	DEG_SIAH_1	2:10	Mutation rewiring degron network	0.3056
p.S11Y	DO220343	KICH	ICGC	SPAAPVPPD	DEG_SIAH_1	2:10	Mutation rewiring degron network	0.3056
p.P9L	TCGA-TS-A7OZ	MESO	TCGA	SPAAPVPPD	DEG_SIAH_1	2:10	Mutation altering degron motif	0.7582
p.G7S	DO225224	BRCA	ICGC	SPAAPVPPD	DEG_SIAH_1	2:10	Mutation altering degron motif	0.6993
p.G7S	DO52562	BRCA	ICGC	SPAAPVPPD	DEG_SIAH_1	2:10	Mutation altering degron motif	0.6993
p.G7S	MHH-ES-1	bone	COSMIC	SPAAPVPPD	DEG_SIAH_1	2:10	Mutation altering degron motif	0.6993
p.A12T	DO222739	ESCA	ICGC	SPAAPVPPD	DEG_SIAH_1	2:10	Mutation rewiring degron network	0.2778
p.W19C	DO228976	LICA	ICGC	SPAAPVPPD	DEG_SIAH_1	2:10	Mutation rewiring degron network	0.0833
p.A4S	DO228978	LICA	ICGC	SPAAPVPPD	DEG_SIAH_1	2:10	Mutation altering degron motif	0.6477
p.R17C	DO48737	LIRI	ICGC	SPAAPVPPD	DEG_SIAH_1	2:10	Mutation rewiring degron network	0.1389
p.R18H	DO41584	UCEC	ICGC	SPAAPVPPD	DEG_SIAH_1	2:10	Mutation rewiring degron network	0.1111
p.R20Q	NCI-H1770	lung	COSMIC	SPAAPVPPD	DEG_SIAH_1	2:10	Mutation rewiring degron network	0.0556

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*NOTE: the Kaplan plots were collected from OncoLnc