DegronMD

Uniprot ID: Q9UF11

Source protein: Pleckstrin homology domain-containing family B member 1

Source gene: PLEKHB1

Class: DEG_SIAH_1

Location: 2:10

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.7228

ASA_SCORE: 88.2333

COIL: 0.9662

CONS_SCORE: 0.3094

DSS_SCORE: 0.7202

HELIX: 0.0224

FCONS_SCORE: 0.8721

RIG_SCORE: 0.6428

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P9L	TCGA-TS-A7OZ	MESO	TCGA	SPAAPVPPD	DEG_SIAH_1	0.7582
p.G7S	DO225224	BRCA	ICGC	SPAAPVPPD	DEG_SIAH_1	0.6993
p.G7S	DO52562	BRCA	ICGC	SPAAPVPPD	DEG_SIAH_1	0.6993
p.G7S	MHH-ES-1	bone	COSMIC	SPAAPVPPD	DEG_SIAH_1	0.6993
p.A4S	DO228978	LICA	ICGC	SPAAPVPPD	DEG_SIAH_1	0.6477
p.S11Y	TCGA-KL-8335	KICH	TCGA	SPAAPVPPD	DEG_SIAH_1	0.3056
p.S11Y	DO220343	KICH	ICGC	SPAAPVPPD	DEG_SIAH_1	0.3056
p.A12T	DO222739	ESCA	ICGC	SPAAPVPPD	DEG_SIAH_1	0.2778
p.R17C	DO48737	LIRI	ICGC	SPAAPVPPD	DEG_SIAH_1	0.1389
p.R18H	DO41584	UCEC	ICGC	SPAAPVPPD	DEG_SIAH_1	0.1111
p.W19C	DO228976	LICA	ICGC	SPAAPVPPD	DEG_SIAH_1	0.0833
p.R20Q	NCI-H1770	lung	COSMIC	SPAAPVPPD	DEG_SIAH_1	0.0556

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UF11	Pleckstrin homology domain-containing family B member 1	DEG_SIAH_1	2:10	SPAAPVPPD	SIAH1,SIAH2,SIAH3	0.7228	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons