LRWD1
UniProt ID: Q9UFC0
Entrez ID: 222229
Protein name: Leucine-rich repeat and WD repeat-containing protein 1 (Centromere protein 33) (CENP-33) (Origin recognition complex-associated protein) (ORC-associated protein) (ORCA)
External links: UniprotKB HGNC RefSeq COSMIC
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FUNCTION: Required for G1/S transition. Recruits and stabilizes the origin recognition complex (ORC) onto chromatin during G1 to establish pre-replication complex (preRC) and to heterochromatic sites in post-replicated cells. Binds a combination of DNA and histone methylation repressive marks on het...
FUNCTION: Required for G1/S transition. Recruits and stabilizes the origin recognition complex (ORC) onto chromatin during G1 to establish pre-replication complex (preRC) and to heterochromatic sites in post-replicated cells. Binds a combination of DNA and histone methylation repressive marks on heterochromatin. Binds histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3 in a cooperative manner with DNA methylation. Required for silencing of major satellite repeats. May be important ORC2, ORC3 and ORC4 stability. {ECO:0000269|PubMed:20850016, ECO:0000269|PubMed:20932478, ECO:0000269|PubMed:21029866, ECO:0000269|PubMed:22427655, ECO:0000269|PubMed:22645314}.
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GO - Biological processes (BP):
chromatin organization [GO:0006325]; DNA replication initiation [GO:0006270]; establishment of protein localization to chromatin [GO:0071169]...
chromatin organization [GO:0006325]; DNA replication initiation [GO:0006270]; establishment of protein localization to chromatin [GO:0071169]
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GO - Molecular function (MF):
chromatin binding [GO:0003682]; methylated histone binding [GO:0035064]; methyl-CpG binding [GO:0008327]...
chromatin binding [GO:0003682]; methylated histone binding [GO:0035064]; methyl-CpG binding [GO:0008327]
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GO - Cellular component (CC):
chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; kinetochore [GO:0000776]; microtubule organizing center [GO:0005815]; nuclear origin of replication recognition complex [GO:0005664]; nucleolus [GO:0005730]; nucleoplasm [GO:0005...
chromosome, telomeric region [GO:0000781]; cytoplasm [GO:0005737]; intracellular membrane-bounded organelle [GO:0043231]; kinetochore [GO:0000776]; microtubule organizing center [GO:0005815]; nuclear origin of replication recognition complex [GO:0005664]; nucleolus [GO:0005730]; nucleoplasm [GO:0005654]; nucleus [GO:0005634]; pericentric heterochromatin [GO:0005721]
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LRWD1
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Kaplan plot for LRWD1 in
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*NOTE: the Kaplan plots were collected from OncoLnc