DegronMD

Uniprot ID: Q9UFC0

Source protein: Leucine-rich repeat and WD repeat-containing protein 1

Source gene: LRWD1

Class: DEG_MDM2_SWIB_1

Location: 343:350

E3 ligase: MDM2

DEGRON score: 0.5467

ASA_SCORE: 19.5625

COIL: 0.1739

CONS_SCORE: 0.7895

DSS_SCORE: 0.0421

HELIX: 0.0419

FCONS_SCORE: 1.2466

RIG_SCORE: 0.9705

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P338L	TCGA-GN-A265	SKCM	TCGA	FSVAWTAL	DEG_MDM2_SWIB_1	0.1944
p.P338L	DO37491	SKCM	ICGC	FSVAWTAL	DEG_MDM2_SWIB_1	0.1944
p.Q355H	DO233260	GACA	ICGC	FSVAWTAL	DEG_MDM2_SWIB_1	0.1944
p.A349T	DO233737	GACA	ICGC	FSVAWTAL	DEG_MDM2_SWIB_1	0.6028
p.V345L	DO228936	LICA	ICGC	FSVAWTAL	DEG_MDM2_SWIB_1	0.5654
p.E340K	ACH-000972	Endometrial/Uterine Cancer	CCLE	FSVAWTAL	DEG_MDM2_SWIB_1	0.25
p.A349V	ACH-002446	Gastric Cancer	CCLE	FSVAWTAL	DEG_MDM2_SWIB_1	0.5825

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UFC0	Leucine-rich repeat and WD repeat-containing protein 1	DEG_MDM2_SWIB_1	343:350	FSVAWTAL	MDM2	0.5467	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons