DegronMD - Q9UFG5(C19orf25)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G59R	DO1301	BRCA	ICGC	LAPEDPPVPFRM	DEG_ODPH_VHL_1	40:51	Mutation rewiring degron network	0.1111
p.E56D	DO233905	GACA	ICGC	LAPEDPPVPFRM	DEG_ODPH_VHL_1	40:51	Mutation rewiring degron network	0.1944
p.T38N	DO228978	LICA	ICGC	LAPEDPPVPFRM	DEG_ODPH_VHL_1	40:51	Mutation rewiring degron network	0.2778
p.R61K	DO23584	LUAD	ICGC	LAPEDPPVPFRM	DEG_ODPH_VHL_1	40:51	Mutation rewiring degron network	0.0556
p.P58L	DO37432	SKCM	ICGC	LAPEDPPVPFRM	DEG_ODPH_VHL_1	40:51	Mutation rewiring degron network	0.1389
p.G59E	SIDM00217	Colorectal Carcinoma	GDSC	LAPEDPPVPFRM	DEG_ODPH_VHL_1	40:51	Mutation rewiring degron network	0.1111
p.G59E	ACH-000999	Colon/Colorectal Cancer	CCLE	LAPEDPPVPFRM	DEG_ODPH_VHL_1	40:51	Mutation rewiring degron network	0.1111
p.R50S	SIDM00145	T-Lymphoblastic Leukemia	GDSC	LAPEDPPVPFRM	DEG_ODPH_VHL_1	40:51	Mutation altering degron motif	0.6316
p.R50M	SIDM00145	T-Lymphoblastic Leukemia	GDSC	LAPEDPPVPFRM	DEG_ODPH_VHL_1	40:51	Mutation altering degron motif	0.7521
p.P48S	ACH-000409	Ovarian Cancer	CCLE	LAPEDPPVPFRM	DEG_ODPH_VHL_1	40:51	Mutation altering degron motif	0.5641
p.S47T	ACH-000800	Lung Cancer	CCLE	LAPEDPPVPFRM	DEG_ODPH_VHL_1	40:51	Mutation altering degron motif	0.7116
p.S46I	ACH-000996	Endometrial/Uterine Cancer	CCLE	LAPEDPPVPFRM	DEG_ODPH_VHL_1	40:51	Mutation altering degron motif	0.7341

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons