DegronMD

Uniprot ID: Q9UFG5

Source protein: UPF0449 protein C19orf25

Source gene: C19orf25

Class: DEG_ODPH_VHL_1

Location: 40:51

E3 ligase: VHL

DEGRON score: 0.891

ASA_SCORE: 83.1167

COIL: 0.7976

CONS_SCORE: 0.4483

DSS_SCORE: 0.5555

HELIX: 0.1033

FCONS_SCORE: 0.7396

RIG_SCORE: 0.7376

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G59R	DO1301	BRCA	ICGC	LAPEDPPVPFRM	DEG_ODPH_VHL_1	0.1111
p.E56D	DO233905	GACA	ICGC	LAPEDPPVPFRM	DEG_ODPH_VHL_1	0.1944
p.T38N	DO228978	LICA	ICGC	LAPEDPPVPFRM	DEG_ODPH_VHL_1	0.2778
p.R61K	DO23584	LUAD	ICGC	LAPEDPPVPFRM	DEG_ODPH_VHL_1	0.0556
p.P58L	DO37432	SKCM	ICGC	LAPEDPPVPFRM	DEG_ODPH_VHL_1	0.1389
p.G59E	SIDM00217	Colorectal Carcinoma	GDSC	LAPEDPPVPFRM	DEG_ODPH_VHL_1	0.1111
p.G59E	ACH-000999	Colon/Colorectal Cancer	CCLE	LAPEDPPVPFRM	DEG_ODPH_VHL_1	0.1111
p.R50S	SIDM00145	T-Lymphoblastic Leukemia	GDSC	LAPEDPPVPFRM	DEG_ODPH_VHL_1	0.6316
p.R50M	SIDM00145	T-Lymphoblastic Leukemia	GDSC	LAPEDPPVPFRM	DEG_ODPH_VHL_1	0.7521
p.P48S	ACH-000409	Ovarian Cancer	CCLE	LAPEDPPVPFRM	DEG_ODPH_VHL_1	0.5641
p.S47T	ACH-000800	Lung Cancer	CCLE	LAPEDPPVPFRM	DEG_ODPH_VHL_1	0.7116
p.S46I	ACH-000996	Endometrial/Uterine Cancer	CCLE	LAPEDPPVPFRM	DEG_ODPH_VHL_1	0.7341

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UFG5	UPF0449 protein C19orf25	DEG_ODPH_VHL_1	40:51	LAPEDPPVPFRM	VHL	0.891	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons