DegronMD - Q9UG22(GIMAP2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q16P	TCGA-05-4398	LUAD	TCGA	SRSELRIIL	DEG_APCC_DBOX_1	19:27	Mutation rewiring degron network	0.25
p.Q16P	DO25847	LUAD	ICGC	SRSELRIIL	DEG_APCC_DBOX_1	19:27	Mutation rewiring degron network	0.25
p.G29D	TCGA-18-3417	LUSC	TCGA	SRSELRIIL	DEG_APCC_DBOX_1	19:27	Mutation rewiring degron network	0.2778
p.G29D	DO26584	LUSC	ICGC	SRSELRIIL	DEG_APCC_DBOX_1	19:27	Mutation rewiring degron network	0.2778
p.R24I	TCGA-A5-A0G1	UCEC	TCGA	SRSELRIIL	DEG_APCC_DBOX_1	19:27	Mutation altering degron motif	0.6991
p.R24I	DO42472	UCEC	ICGC	SRSELRIIL	DEG_APCC_DBOX_1	19:27	Mutation altering degron motif	0.6991
p.G32E	TCGA-D3-A8GN	SKCM	TCGA	SRSELRIIL	DEG_APCC_DBOX_1	19:27	Mutation rewiring degron network	0.1944
p.G32E	TCGA-FR-A8YC	SKCM	TCGA	SRSELRIIL	DEG_APCC_DBOX_1	19:27	Mutation rewiring degron network	0.1944
p.G32E	TCGA-FS-A1ZA	SKCM	TCGA	SRSELRIIL	DEG_APCC_DBOX_1	19:27	Mutation rewiring degron network	0.1944
p.G32E	DO220911	MELA	ICGC	SRSELRIIL	DEG_APCC_DBOX_1	19:27	Mutation rewiring degron network	0.1944
p.G32E	DO229491	SKCA	ICGC	SRSELRIIL	DEG_APCC_DBOX_1	19:27	Mutation rewiring degron network	0.1944
p.G32E	DO37551	SKCM	ICGC	SRSELRIIL	DEG_APCC_DBOX_1	19:27	Mutation rewiring degron network	0.1944
p.G32E	DO50301	SKCM	ICGC	SRSELRIIL	DEG_APCC_DBOX_1	19:27	Mutation rewiring degron network	0.1944
p.G32E	DO51240	SKCM	ICGC	SRSELRIIL	DEG_APCC_DBOX_1	19:27	Mutation rewiring degron network	0.1944
p.G32E	SIDM01175	Other Sarcomas	GDSC	SRSELRIIL	DEG_APCC_DBOX_1	19:27	Mutation rewiring degron network	0.1944
p.G32E	ACH-002309	Sarcoma	CCLE	SRSELRIIL	DEG_APCC_DBOX_1	19:27	Mutation rewiring degron network	0.1944
p.G32E	SW684	soft tissue	COSMIC	SRSELRIIL	DEG_APCC_DBOX_1	19:27	Mutation rewiring degron network	0.1944
p.S36R	TCGA-EB-A551	SKCM	TCGA	SRSELRIIL	DEG_APCC_DBOX_1	19:27	Mutation blocking phosphorylation signal	0.5278
p.S36R	DO47453	SKCM	ICGC	SRSELRIIL	DEG_APCC_DBOX_1	19:27	Mutation blocking phosphorylation signal	0.5278
p.W9C	TCGA-EE-A2GR	SKCM	TCGA	SRSELRIIL	DEG_APCC_DBOX_1	19:27	Mutation rewiring degron network	0.0556
p.W9C	DO37996	SKCM	ICGC	SRSELRIIL	DEG_APCC_DBOX_1	19:27	Mutation rewiring degron network	0.0556
p.K35T	TCGA-EO-A22X	UCEC	TCGA	SRSELRIIL	DEG_APCC_DBOX_1	19:27	Mutation blocking ubiquitination signal	0.5556
p.K35T	DO43907	UCEC	ICGC	SRSELRIIL	DEG_APCC_DBOX_1	19:27	Mutation blocking ubiquitination signal	0.5556
p.G29C	TCGA-ER-A19H	SKCM	TCGA	SRSELRIIL	DEG_APCC_DBOX_1	19:27	Mutation rewiring degron network	0.2778
p.G29C	DO47299	SKCM	ICGC	SRSELRIIL	DEG_APCC_DBOX_1	19:27	Mutation rewiring degron network	0.2778
p.G28S	DO44273	BRCA	ICGC	SRSELRIIL	DEG_APCC_DBOX_1	19:27	Mutation rewiring degron network	0.3056
p.R16C	DO233888	GACA	ICGC	SRSELRIIL	DEG_APCC_DBOX_1	19:27	Mutation rewiring degron network	0.25
p.R16C	DO36556	READ	ICGC	SRSELRIIL	DEG_APCC_DBOX_1	19:27	Mutation rewiring degron network	0.25
p.R16C	DO38376	STAD	ICGC	SRSELRIIL	DEG_APCC_DBOX_1	19:27	Mutation rewiring degron network	0.25
p.R27C	DO228947	LICA	ICGC	SRSELRIIL	DEG_APCC_DBOX_1	19:27	Mutation altering degron motif	0.8301
p.W9L	DO228974	LICA	ICGC	SRSELRIIL	DEG_APCC_DBOX_1	19:27	Mutation rewiring degron network	0.0556
p.G34V	DO229018	LICA	ICGC	SRSELRIIL	DEG_APCC_DBOX_1	19:27	Mutation rewiring degron network	0.1389
p.A37S	DO229006	LICA	ICGC	SRSELRIIL	DEG_APCC_DBOX_1	19:27	Mutation rewiring degron network	0.0556
p.LF36LI	DO222363	MELA	ICGC	SRSELRIIL	DEG_APCC_DBOX_1	19:27	Mutation blocking phosphorylation signal	0.4444
p.S30L	DO222423	MELA	ICGC	SRSELRIIL	DEG_APCC_DBOX_1	19:27	Mutation substituting flanking lysine	0.3611
p.S30L	DO37425	SKCM	ICGC	SRSELRIIL	DEG_APCC_DBOX_1	19:27	Mutation substituting flanking lysine	0.3611
p.R16H	DO38376	STAD	ICGC	SRSELRIIL	DEG_APCC_DBOX_1	19:27	Mutation rewiring degron network	0.25
p.I26V	SIDM01612	Endometrial Carcinoma	GDSC	SRSELRIIL	DEG_APCC_DBOX_1	19:27	Mutation altering degron motif	0.5965
p.I26V	ACH-000946	Endometrial/Uterine Cancer	CCLE	SRSELRIIL	DEG_APCC_DBOX_1	19:27	Mutation altering degron motif	0.5965
p.G10D	LOXIMVI	skin	COSMIC	SRSELRIIL	DEG_APCC_DBOX_1	19:27	Mutation rewiring degron network	0.0833
p.R12S	BT-474	breast	COSMIC	SRSELRIIL	DEG_APCC_DBOX_1	19:27	Mutation rewiring degron network	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GIMAP2

UniProt ID: Q9UG22

Entrez ID: 26157

Protein name: GTPase IMAP family member 2 (Immunity-associated protein 2) (hIMAP2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GIMAP2 in