DegronMD

Uniprot ID: Q9UG22

Source protein: GTPase IMAP family member 2

Source gene: GIMAP2

Class: DEG_APCC_DBOX_1

Location: 19:27

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5343

ASA_SCORE: 42.7

COIL: 0.3666

CONS_SCORE: 0.4618

DSS_SCORE: 0.3978

HELIX: 0.0261

FCONS_SCORE: 0.825

RIG_SCORE: 0.8071

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q16P	TCGA-05-4398	LUAD	TCGA	SRSELRIIL	DEG_APCC_DBOX_1	0.25
p.Q16P	DO25847	LUAD	ICGC	SRSELRIIL	DEG_APCC_DBOX_1	0.25
p.G29D	TCGA-18-3417	LUSC	TCGA	SRSELRIIL	DEG_APCC_DBOX_1	0.2778
p.G29D	DO26584	LUSC	ICGC	SRSELRIIL	DEG_APCC_DBOX_1	0.2778
p.R24I	TCGA-A5-A0G1	UCEC	TCGA	SRSELRIIL	DEG_APCC_DBOX_1	0.6991
p.R24I	DO42472	UCEC	ICGC	SRSELRIIL	DEG_APCC_DBOX_1	0.6991
p.G32E	TCGA-D3-A8GN	SKCM	TCGA	SRSELRIIL	DEG_APCC_DBOX_1	0.1944
p.G32E	TCGA-FR-A8YC	SKCM	TCGA	SRSELRIIL	DEG_APCC_DBOX_1	0.1944
p.G32E	TCGA-FS-A1ZA	SKCM	TCGA	SRSELRIIL	DEG_APCC_DBOX_1	0.1944
p.G32E	DO220911	MELA	ICGC	SRSELRIIL	DEG_APCC_DBOX_1	0.1944
p.G32E	DO229491	SKCA	ICGC	SRSELRIIL	DEG_APCC_DBOX_1	0.1944
p.G32E	DO37551	SKCM	ICGC	SRSELRIIL	DEG_APCC_DBOX_1	0.1944
p.G32E	DO50301	SKCM	ICGC	SRSELRIIL	DEG_APCC_DBOX_1	0.1944
p.G32E	DO51240	SKCM	ICGC	SRSELRIIL	DEG_APCC_DBOX_1	0.1944
p.G32E	SIDM01175	Other Sarcomas	GDSC	SRSELRIIL	DEG_APCC_DBOX_1	0.1944
p.G32E	ACH-002309	Sarcoma	CCLE	SRSELRIIL	DEG_APCC_DBOX_1	0.1944
p.G32E	SW684	soft_tissue	COSMIC	SRSELRIIL	DEG_APCC_DBOX_1	0.1944
p.S36R	TCGA-EB-A551	SKCM	TCGA	SRSELRIIL	DEG_APCC_DBOX_1	0.5278
p.S36R	DO47453	SKCM	ICGC	SRSELRIIL	DEG_APCC_DBOX_1	0.5278
p.W9C	TCGA-EE-A2GR	SKCM	TCGA	SRSELRIIL	DEG_APCC_DBOX_1	0.0556
p.W9C	DO37996	SKCM	ICGC	SRSELRIIL	DEG_APCC_DBOX_1	0.0556
p.K35T	TCGA-EO-A22X	UCEC	TCGA	SRSELRIIL	DEG_APCC_DBOX_1	0.5556
p.K35T	DO43907	UCEC	ICGC	SRSELRIIL	DEG_APCC_DBOX_1	0.5556
p.G29C	TCGA-ER-A19H	SKCM	TCGA	SRSELRIIL	DEG_APCC_DBOX_1	0.2778
p.G29C	DO47299	SKCM	ICGC	SRSELRIIL	DEG_APCC_DBOX_1	0.2778
p.G28S	DO44273	BRCA	ICGC	SRSELRIIL	DEG_APCC_DBOX_1	0.3056
p.R16C	DO233888	GACA	ICGC	SRSELRIIL	DEG_APCC_DBOX_1	0.25
p.R16C	DO36556	READ	ICGC	SRSELRIIL	DEG_APCC_DBOX_1	0.25
p.R16C	DO38376	STAD	ICGC	SRSELRIIL	DEG_APCC_DBOX_1	0.25
p.R27C	DO228947	LICA	ICGC	SRSELRIIL	DEG_APCC_DBOX_1	0.8301
p.W9L	DO228974	LICA	ICGC	SRSELRIIL	DEG_APCC_DBOX_1	0.0556
p.G34V	DO229018	LICA	ICGC	SRSELRIIL	DEG_APCC_DBOX_1	0.1389
p.A37S	DO229006	LICA	ICGC	SRSELRIIL	DEG_APCC_DBOX_1	0.0556
p.LF36LI	DO222363	MELA	ICGC	SRSELRIIL	DEG_APCC_DBOX_1	0.4444
p.S30L	DO222423	MELA	ICGC	SRSELRIIL	DEG_APCC_DBOX_1	0.3611
p.S30L	DO37425	SKCM	ICGC	SRSELRIIL	DEG_APCC_DBOX_1	0.3611
p.R16H	DO38376	STAD	ICGC	SRSELRIIL	DEG_APCC_DBOX_1	0.25
p.I26V	SIDM01612	Endometrial Carcinoma	GDSC	SRSELRIIL	DEG_APCC_DBOX_1	0.5965
p.I26V	ACH-000946	Endometrial/Uterine Cancer	CCLE	SRSELRIIL	DEG_APCC_DBOX_1	0.5965
p.G10D	LOXIMVI	skin	COSMIC	SRSELRIIL	DEG_APCC_DBOX_1	0.0833
p.R12S	BT-474	breast	COSMIC	SRSELRIIL	DEG_APCC_DBOX_1	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: SRSELRIIL

Degron related mutations and impact score

Drug responses associated with GIMAP2 mutations

All proteins holding degron of SRSELRIIL

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UG22	GTPase IMAP family member 2	DEG_APCC_DBOX_1	19:27	SRSELRIIL	APC,CDC20,FZR1	0.5343	More...