DegronMD - Q9UGB7(MIOX)

GO - Biological processes (BP): inositol catabolic process [GO:0019310]

GO - Molecular function (MF): aldo-keto reductase (NADP) activity [GO:0004033]; ferric iron binding [GO:0008199]; inositol oxygenase activity [GO:0050113]; oxidoreductase activity, acting on NAD(P)H [GO:0016651]; oxidoreductase activity, acting on single donors with incorporation of molecular oxygen [GO:0016701]

GO - Cellular component (CC): cytoplasm [GO:0005737]; cytosol [GO:0005829]; inclusion body [GO:0016234]

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P254H	CML-T1	haematopoietic and lymphoid tissue	COSMIC	NKFDLYTKCP	CBL_PTK	250:259	Mutation altering degron motif	0.7694
p.P259L	SIDM00369	Esophageal Squamous Cell Carcinoma	GDSC	NKFDLYTKCP	CBL_PTK	250:259	Mutation altering degron motif	0.7582
p.P259L	SIDM00592	Oral Cavity Carcinoma	GDSC	NKFDLYTKCP	CBL_PTK	250:259	Mutation altering degron motif	0.7582
p.P259L	SIDM00567	Other Solid Cancers	GDSC	NKFDLYTKCP	CBL_PTK	250:259	Mutation altering degron motif	0.7582
p.P259L	SIDM01691	Chronic Myelogenous Leukemia	GDSC	NKFDLYTKCP	CBL_PTK	250:259	Mutation altering degron motif	0.7582
p.P259L	ACH-000321	Leukemia	CCLE	NKFDLYTKCP	CBL_PTK	250:259	Mutation altering degron motif	0.7582
p.P259L	ACH-000647	Esophageal Cancer	CCLE	NKFDLYTKCP	CBL_PTK	250:259	Mutation altering degron motif	0.7582
p.P259L	ACH-000776	Brain Cancer	CCLE	NKFDLYTKCP	CBL_PTK	250:259	Mutation altering degron motif	0.7582
p.P259L	ACH-002244	Head and Neck Cancer	CCLE	NKFDLYTKCP	CBL_PTK	250:259	Mutation altering degron motif	0.7582
p.P259L	TE-1	oesophagus	COSMIC	NKFDLYTKCP	CBL_PTK	250:259	Mutation altering degron motif	0.7582
p.P259L	HO-1-N-1	salivary gland	COSMIC	NKFDLYTKCP	CBL_PTK	250:259	Mutation altering degron motif	0.7582
p.P259L	ONS-76	central nervous system	COSMIC	NKFDLYTKCP	CBL_PTK	250:259	Mutation altering degron motif	0.7582
p.G258R	DO38192	STAD	ICGC	NKFDLYTKCP	CBL_PTK	250:259	Mutation altering degron motif	0.7568
p.G258R	DO42312	UCEC	ICGC	NKFDLYTKCP	CBL_PTK	250:259	Mutation altering degron motif	0.7568
p.G258V	NCI-H661	lung	COSMIC	NKFDLYTKCP	CBL_PTK	250:259	Mutation altering degron motif	0.7532
p.G258E	NCI-H2110	lung	COSMIC	NKFDLYTKCP	CBL_PTK	250:259	Mutation altering degron motif	0.7199
p.P259T	SIDM00958	Chronic Myelogenous Leukemia	GDSC	NKFDLYTKCP	CBL_PTK	250:259	Mutation altering degron motif	0.7031
p.P259T	ACH-000920	Leukemia	CCLE	NKFDLYTKCP	CBL_PTK	250:259	Mutation altering degron motif	0.7031
p.P259T	CML-T1	haematopoietic and lymphoid tissue	COSMIC	NKFDLYTKCP	CBL_PTK	250:259	Mutation altering degron motif	0.7031
p.P254S	DO558	BLCA	ICGC	NKFDLYTKCP	CBL_PTK	250:259	Mutation altering degron motif	0.6752

Showing 1 to 20 of 43 entries

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Kaplan plot for MIOX in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MIOX

UniProt ID: Q9UGB7

Entrez ID: 55586

Protein name: Inositol oxygenase (EC 1.13.99.1) (Aldehyde reductase-like 6) (Kidney-specific protein 32) (Myo-inositol oxygenase) (MI oxygenase) (Renal-specific oxidoreductase)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MIOX in