DegronMD - Q9UGB7(MIOX)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R268Q	TCGA-27-1835	GBM	TCGA	NKFDLYTKCP	CBL_PTK	250:259	Mutation rewiring degron network	0.0833
p.R268Q	DO11208	GBM	ICGC	NKFDLYTKCP	CBL_PTK	250:259	Mutation rewiring degron network	0.0833
p.W245C	TCGA-CM-4743	COAD	TCGA	NKFDLYTKCP	CBL_PTK	250:259	Mutation rewiring degron network	0.1944
p.W245C	DO8103	COAD	ICGC	NKFDLYTKCP	CBL_PTK	250:259	Mutation rewiring degron network	0.1944
p.R247Q	TCGA-CM-6167	COAD	TCGA	NKFDLYTKCP	CBL_PTK	250:259	Mutation rewiring degron network	0.25
p.P254S	DO558	BLCA	ICGC	NKFDLYTKCP	CBL_PTK	250:259	Mutation altering degron motif	0.6752
p.G268E	DO219080	HNSC	ICGC	NKFDLYTKCP	CBL_PTK	250:259	Mutation rewiring degron network	0.0833
p.M242I	DO44696	LICA	ICGC	NKFDLYTKCP	CBL_PTK	250:259	Mutation rewiring degron network	0.1111
p.G258R	DO38192	STAD	ICGC	NKFDLYTKCP	CBL_PTK	250:259	Mutation altering degron motif	0.7568
p.G258R	DO42312	UCEC	ICGC	NKFDLYTKCP	CBL_PTK	250:259	Mutation altering degron motif	0.7568
p.P259T	SIDM00958	Chronic Myelogenous Leukemia	GDSC	NKFDLYTKCP	CBL_PTK	250:259	Mutation altering degron motif	0.7031
p.P259T	ACH-000920	Leukemia	CCLE	NKFDLYTKCP	CBL_PTK	250:259	Mutation altering degron motif	0.7031
p.P259T	CML-T1	haematopoietic and lymphoid tissue	COSMIC	NKFDLYTKCP	CBL_PTK	250:259	Mutation altering degron motif	0.7031
p.P262L	SIDM00630	Breast Carcinoma	GDSC	NKFDLYTKCP	CBL_PTK	250:259	Mutation rewiring degron network	0.25
p.P262L	MDA-MB-415	breast	COSMIC	NKFDLYTKCP	CBL_PTK	250:259	Mutation rewiring degron network	0.25
p.P259L	SIDM00369	Esophageal Squamous Cell Carcinoma	GDSC	NKFDLYTKCP	CBL_PTK	250:259	Mutation altering degron motif	0.7582
p.P259L	SIDM00592	Oral Cavity Carcinoma	GDSC	NKFDLYTKCP	CBL_PTK	250:259	Mutation altering degron motif	0.7582
p.P259L	SIDM00567	Other Solid Cancers	GDSC	NKFDLYTKCP	CBL_PTK	250:259	Mutation altering degron motif	0.7582
p.P259L	SIDM01691	Chronic Myelogenous Leukemia	GDSC	NKFDLYTKCP	CBL_PTK	250:259	Mutation altering degron motif	0.7582
p.P259L	ACH-000321	Leukemia	CCLE	NKFDLYTKCP	CBL_PTK	250:259	Mutation altering degron motif	0.7582
p.P259L	ACH-000647	Esophageal Cancer	CCLE	NKFDLYTKCP	CBL_PTK	250:259	Mutation altering degron motif	0.7582
p.P259L	ACH-000776	Brain Cancer	CCLE	NKFDLYTKCP	CBL_PTK	250:259	Mutation altering degron motif	0.7582
p.P259L	ACH-002244	Head and Neck Cancer	CCLE	NKFDLYTKCP	CBL_PTK	250:259	Mutation altering degron motif	0.7582
p.P259L	TE-1	oesophagus	COSMIC	NKFDLYTKCP	CBL_PTK	250:259	Mutation altering degron motif	0.7582
p.P259L	HO-1-N-1	salivary gland	COSMIC	NKFDLYTKCP	CBL_PTK	250:259	Mutation altering degron motif	0.7582
p.P259L	ONS-76	central nervous system	COSMIC	NKFDLYTKCP	CBL_PTK	250:259	Mutation altering degron motif	0.7582
p.K251R	SIDM01028	Esophageal Squamous Cell Carcinoma	GDSC	NKFDLYTKCP	CBL_PTK	250:259	Mutation altering degron motif	0.6126
p.K251R	SIDM00348	Esophageal Squamous Cell Carcinoma	GDSC	NKFDLYTKCP	CBL_PTK	250:259	Mutation altering degron motif	0.6126
p.K251R	SIDM01446	Glioblastoma	GDSC	NKFDLYTKCP	CBL_PTK	250:259	Mutation altering degron motif	0.6126
p.K251R	TE-11	oesophagus	COSMIC	NKFDLYTKCP	CBL_PTK	250:259	Mutation altering degron motif	0.6126
p.K251R	KYSE-410	oesophagus	COSMIC	NKFDLYTKCP	CBL_PTK	250:259	Mutation altering degron motif	0.6126
p.D263Y	SIDM01122	Non-Small Cell Lung Carcinoma	GDSC	NKFDLYTKCP	CBL_PTK	250:259	Mutation rewiring degron network	0.2222
p.D263Y	ACH-000853	Lung Cancer	CCLE	NKFDLYTKCP	CBL_PTK	250:259	Mutation rewiring degron network	0.2222
p.D263Y	NCI-H661	lung	COSMIC	NKFDLYTKCP	CBL_PTK	250:259	Mutation rewiring degron network	0.2222
p.D263N	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	NKFDLYTKCP	CBL_PTK	250:259	Mutation rewiring degron network	0.2222
p.D263N	ACH-000929	Lung Cancer	CCLE	NKFDLYTKCP	CBL_PTK	250:259	Mutation rewiring degron network	0.2222
p.D263N	NCI-H2110	lung	COSMIC	NKFDLYTKCP	CBL_PTK	250:259	Mutation rewiring degron network	0.2222
p.E248V	SIDM00500	Colorectal Carcinoma	GDSC	NKFDLYTKCP	CBL_PTK	250:259	Mutation rewiring degron network	0.2778
p.E248V	ACH-000959	Colon/Colorectal Cancer	CCLE	NKFDLYTKCP	CBL_PTK	250:259	Mutation rewiring degron network	0.2778
p.R247W	NCI-H630	large intestine	COSMIC	NKFDLYTKCP	CBL_PTK	250:259	Mutation rewiring degron network	0.25
p.P254H	CML-T1	haematopoietic and lymphoid tissue	COSMIC	NKFDLYTKCP	CBL_PTK	250:259	Mutation altering degron motif	0.7694
p.G258E	NCI-H2110	lung	COSMIC	NKFDLYTKCP	CBL_PTK	250:259	Mutation altering degron motif	0.7199
p.G258V	NCI-H661	lung	COSMIC	NKFDLYTKCP	CBL_PTK	250:259	Mutation altering degron motif	0.7532

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MIOX

UniProt ID: Q9UGB7

Entrez ID: 55586

Protein name: Inositol oxygenase (EC 1.13.99.1) (Aldehyde reductase-like 6) (Kidney-specific protein 32) (Myo-inositol oxygenase) (MI oxygenase) (Renal-specific oxidoreductase)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MIOX in