DegronMD

Uniprot ID: Q9UGB7

Source protein: Inositol oxygenase

Source gene: MIOX

Class: CBL_PTK

Location: 250:259

E3 ligase: CBL

DEGRON score: 0.6806

ASA_SCORE: 80.86

COIL: 0.7822

CONS_SCORE: 0.8012

DSS_SCORE: 0.0783

HELIX: 0.1655

FCONS_SCORE: 1.3277

RIG_SCORE: 0.8729

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R268Q	TCGA-27-1835	GBM	TCGA	NKFDLYTKCP	CBL_PTK	0.0833
p.R268Q	DO11208	GBM	ICGC	NKFDLYTKCP	CBL_PTK	0.0833
p.W245C	TCGA-CM-4743	COAD	TCGA	NKFDLYTKCP	CBL_PTK	0.1944
p.W245C	DO8103	COAD	ICGC	NKFDLYTKCP	CBL_PTK	0.1944
p.R247Q	TCGA-CM-6167	COAD	TCGA	NKFDLYTKCP	CBL_PTK	0.25
p.P254S	DO558	BLCA	ICGC	NKFDLYTKCP	CBL_PTK	0.6752
p.G268E	DO219080	HNSC	ICGC	NKFDLYTKCP	CBL_PTK	0.0833
p.M242I	DO44696	LICA	ICGC	NKFDLYTKCP	CBL_PTK	0.1111
p.G258R	DO38192	STAD	ICGC	NKFDLYTKCP	CBL_PTK	0.7568
p.G258R	DO42312	UCEC	ICGC	NKFDLYTKCP	CBL_PTK	0.7568
p.P259T	SIDM00958	Chronic Myelogenous Leukemia	GDSC	NKFDLYTKCP	CBL_PTK	0.7031
p.P259T	ACH-000920	Leukemia	CCLE	NKFDLYTKCP	CBL_PTK	0.7031
p.P259T	CML-T1	haematopoietic_and_lymphoid_tissue	COSMIC	NKFDLYTKCP	CBL_PTK	0.7031
p.P262L	SIDM00630	Breast Carcinoma	GDSC	NKFDLYTKCP	CBL_PTK	0.25
p.P262L	MDA-MB-415	breast	COSMIC	NKFDLYTKCP	CBL_PTK	0.25
p.P259L	SIDM00369	Esophageal Squamous Cell Carcinoma	GDSC	NKFDLYTKCP	CBL_PTK	0.7582
p.P259L	SIDM00592	Oral Cavity Carcinoma	GDSC	NKFDLYTKCP	CBL_PTK	0.7582
p.P259L	SIDM00567	Other Solid Cancers	GDSC	NKFDLYTKCP	CBL_PTK	0.7582
p.P259L	SIDM01691	Chronic Myelogenous Leukemia	GDSC	NKFDLYTKCP	CBL_PTK	0.7582
p.P259L	ACH-000321	Leukemia	CCLE	NKFDLYTKCP	CBL_PTK	0.7582
p.P259L	ACH-000647	Esophageal Cancer	CCLE	NKFDLYTKCP	CBL_PTK	0.7582
p.P259L	ACH-000776	Brain Cancer	CCLE	NKFDLYTKCP	CBL_PTK	0.7582
p.P259L	ACH-002244	Head and Neck Cancer	CCLE	NKFDLYTKCP	CBL_PTK	0.7582
p.P259L	TE-1	oesophagus	COSMIC	NKFDLYTKCP	CBL_PTK	0.7582
p.P259L	HO-1-N-1	salivary_gland	COSMIC	NKFDLYTKCP	CBL_PTK	0.7582
p.P259L	ONS-76	central_nervous_system	COSMIC	NKFDLYTKCP	CBL_PTK	0.7582
p.K251R	SIDM01028	Esophageal Squamous Cell Carcinoma	GDSC	NKFDLYTKCP	CBL_PTK	0.6126
p.K251R	SIDM00348	Esophageal Squamous Cell Carcinoma	GDSC	NKFDLYTKCP	CBL_PTK	0.6126
p.K251R	SIDM01446	Glioblastoma	GDSC	NKFDLYTKCP	CBL_PTK	0.6126
p.K251R	TE-11	oesophagus	COSMIC	NKFDLYTKCP	CBL_PTK	0.6126
p.K251R	KYSE-410	oesophagus	COSMIC	NKFDLYTKCP	CBL_PTK	0.6126
p.D263Y	SIDM01122	Non-Small Cell Lung Carcinoma	GDSC	NKFDLYTKCP	CBL_PTK	0.2222
p.D263Y	ACH-000853	Lung Cancer	CCLE	NKFDLYTKCP	CBL_PTK	0.2222
p.D263Y	NCI-H661	lung	COSMIC	NKFDLYTKCP	CBL_PTK	0.2222
p.D263N	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	NKFDLYTKCP	CBL_PTK	0.2222
p.D263N	ACH-000929	Lung Cancer	CCLE	NKFDLYTKCP	CBL_PTK	0.2222
p.D263N	NCI-H2110	lung	COSMIC	NKFDLYTKCP	CBL_PTK	0.2222
p.E248V	SIDM00500	Colorectal Carcinoma	GDSC	NKFDLYTKCP	CBL_PTK	0.2778
p.E248V	ACH-000959	Colon/Colorectal Cancer	CCLE	NKFDLYTKCP	CBL_PTK	0.2778
p.R247W	NCI-H630	large_intestine	COSMIC	NKFDLYTKCP	CBL_PTK	0.25
p.P254H	CML-T1	haematopoietic_and_lymphoid_tissue	COSMIC	NKFDLYTKCP	CBL_PTK	0.7694
p.G258E	NCI-H2110	lung	COSMIC	NKFDLYTKCP	CBL_PTK	0.7199
p.G258V	NCI-H661	lung	COSMIC	NKFDLYTKCP	CBL_PTK	0.7532

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: NKFDLYTKCP

Degron related mutations and impact score

Drug responses associated with MIOX mutations

All proteins holding degron of NKFDLYTKCP

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UGB7	Inositol oxygenase	CBL_PTK	250:259	NKFDLYTKCP	CBL	0.6806	More...