DegronMD - Q9UGN5(PARP2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.H311Y	TCGA-B5-A1MX	UCEC	TCGA	NEFYTRIP	CBL_PTK	303:310	Mutation rewiring degron network	0.3056
p.H311Y	SIDM00789	Colorectal Carcinoma	GDSC	NEFYTRIP	CBL_PTK	303:310	Mutation rewiring degron network	0.3056
p.H311Y	HCT-15	large intestine	COSMIC	NEFYTRIP	CBL_PTK	303:310	Mutation rewiring degron network	0.3056
p.P310L	TCGA-D1-A103	UCEC	TCGA	NEFYTRIP	CBL_PTK	303:310	Mutation altering degron motif	0.7582
p.P305T	DO234257	ESAD	ICGC	NEFYTRIP	CBL_PTK	303:310	Mutation altering degron motif	0.7031
p.T304N	DO223048	ESCA	ICGC	NEFYTRIP	CBL_PTK	303:310	Mutation altering degron motif	0.7055
p.R309W	DO233936	GACA	ICGC	NEFYTRIP	CBL_PTK	303:310	Mutation altering degron motif	0.8634
p.L314R	DO34688	PACA	ICGC	NEFYTRIP	CBL_PTK	303:310	Mutation rewiring degron network	0.2222
p.P306T	DO48920	PBCA	ICGC	NEFYTRIP	CBL_PTK	303:310	Mutation altering degron motif	0.7031
p.P297L	DO42312	UCEC	ICGC	NEFYTRIP	CBL_PTK	303:310	Mutation rewiring degron network	0.1667
p.H298Y	DO41999	UCEC	ICGC	NEFYTRIP	CBL_PTK	303:310	Mutation rewiring degron network	0.1944
p.H298Y	ACH-000997	Colon/Colorectal Cancer	CCLE	NEFYTRIP	CBL_PTK	303:310	Mutation rewiring degron network	0.1944
p.H298Y	ACH-001061	Colon/Colorectal Cancer	CCLE	NEFYTRIP	CBL_PTK	303:310	Mutation rewiring degron network	0.1944
p.H298Y	HCT-15	large intestine	COSMIC	NEFYTRIP	CBL_PTK	303:310	Mutation rewiring degron network	0.1944
p.A301V	SIDM01617	Endometrial Carcinoma	GDSC	NEFYTRIP	CBL_PTK	303:310	Mutation rewiring degron network	0.2778
p.I318T	ACH-000373	Leukemia	CCLE	NEFYTRIP	CBL_PTK	303:310	Mutation rewiring degron network	0.1111

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons