DegronMD

Uniprot ID: Q9UGN5

Source protein: Poly [ADP-ribose] polymerase 2

Source gene: PARP2

Class: CBL_PTK

Location: 303:310

E3 ligase: CBL

DEGRON score: 0.5031

ASA_SCORE: 44.6375

COIL: 0.5936

CONS_SCORE: 0.7134

DSS_SCORE: 0.1873

HELIX: 0.2106

FCONS_SCORE: 1.4033

RIG_SCORE: 0.8174

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H311Y	TCGA-B5-A1MX	UCEC	TCGA	NEFYTRIP	CBL_PTK	0.3056
p.H311Y	SIDM00789	Colorectal Carcinoma	GDSC	NEFYTRIP	CBL_PTK	0.3056
p.H311Y	HCT-15	large_intestine	COSMIC	NEFYTRIP	CBL_PTK	0.3056
p.P310L	TCGA-D1-A103	UCEC	TCGA	NEFYTRIP	CBL_PTK	0.7582
p.P305T	DO234257	ESAD	ICGC	NEFYTRIP	CBL_PTK	0.7031
p.T304N	DO223048	ESCA	ICGC	NEFYTRIP	CBL_PTK	0.7055
p.R309W	DO233936	GACA	ICGC	NEFYTRIP	CBL_PTK	0.8634
p.L314R	DO34688	PACA	ICGC	NEFYTRIP	CBL_PTK	0.2222
p.P306T	DO48920	PBCA	ICGC	NEFYTRIP	CBL_PTK	0.7031
p.P297L	DO42312	UCEC	ICGC	NEFYTRIP	CBL_PTK	0.1667
p.H298Y	DO41999	UCEC	ICGC	NEFYTRIP	CBL_PTK	0.1944
p.H298Y	ACH-000997	Colon/Colorectal Cancer	CCLE	NEFYTRIP	CBL_PTK	0.1944
p.H298Y	ACH-001061	Colon/Colorectal Cancer	CCLE	NEFYTRIP	CBL_PTK	0.1944
p.H298Y	HCT-15	large_intestine	COSMIC	NEFYTRIP	CBL_PTK	0.1944
p.A301V	SIDM01617	Endometrial Carcinoma	GDSC	NEFYTRIP	CBL_PTK	0.2778
p.I318T	ACH-000373	Leukemia	CCLE	NEFYTRIP	CBL_PTK	0.1111

Drug responses associated with PARP2 mutations

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM00362	UNCLASSIFIED\|Burkitt_lymphoma	p.Y208C (No)	GDSC	Olaparib	20.6667
SIDM00362	UNCLASSIFIED\|Burkitt_lymphoma	p.Y208C (No)	GDSC	Veliparib	20.6667
SIDM00362	UNCLASSIFIED\|Burkitt_lymphoma	p.Y208C (No)	GDSC	Rucaparib	20.6667
SIDM00362	UNCLASSIFIED\|Burkitt_lymphoma	p.Y208C (No)	GDSC	Talazoparib	0.9622
SIDM00362	UNCLASSIFIED\|Burkitt_lymphoma	p.Y208C (No)	GDSC	PARP_9495	1.4481
SIDM00362	UNCLASSIFIED\|Burkitt_lymphoma	p.Y208C (No)	GDSC	PARP_0108	0.0664
SIDM00362	UNCLASSIFIED\|Burkitt_lymphoma	p.Y208C (No)	GDSC	PARP_9482	0.0389
SIDM00362	UNCLASSIFIED\|Burkitt_lymphoma	p.Y208C (No)	GDSC	Olaparib	26.3112
SIDM00362	UNCLASSIFIED\|Burkitt_lymphoma	p.Y208C (No)	GDSC	Olaparib	14.255
SIDM00362	UNCLASSIFIED\|Burkitt_lymphoma	p.Y208C (No)	GDSC	Niraparib	2.125
SIDM00362	UNCLASSIFIED\|Burkitt_lymphoma	p.Y208C (No)	GDSC	Talazoparib	0.5341
SIDM00380	UNCLASSIFIED\|haematopoietic_neoplasm_other	p.I331T (No)	GDSC	Olaparib	2.7068
SIDM00380	UNCLASSIFIED\|haematopoietic_neoplasm_other	p.I331T (No)	GDSC	Veliparib	6.3496
SIDM00380	UNCLASSIFIED\|haematopoietic_neoplasm_other	p.I331T (No)	GDSC	Rucaparib	12.1744
SIDM00380	UNCLASSIFIED\|haematopoietic_neoplasm_other	p.I331T (No)	GDSC	Talazoparib	14.6566
SIDM00380	UNCLASSIFIED\|haematopoietic_neoplasm_other	p.I331T (No)	GDSC	PARP_9495	25.1983
SIDM00380	UNCLASSIFIED\|haematopoietic_neoplasm_other	p.I331T (No)	GDSC	PARP_0108	0.2039
SIDM00380	UNCLASSIFIED\|haematopoietic_neoplasm_other	p.I331T (No)	GDSC	PARP_9482	0.8037
SIDM00380	UNCLASSIFIED\|haematopoietic_neoplasm_other	p.I331T (No)	GDSC	Olaparib	24.2398
SIDM00380	UNCLASSIFIED\|haematopoietic_neoplasm_other	p.I331T (No)	GDSC	Niraparib	15.996
SIDM00959	LAML\|acute_myeloid_leukaemia	p.I175V (No)	GDSC	Olaparib	16.5353
SIDM00959	LAML\|acute_myeloid_leukaemia	p.I175V (No)	GDSC	Veliparib	25.2986
SIDM00959	LAML\|acute_myeloid_leukaemia	p.I175V (No)	GDSC	Rucaparib	21.7632
SIDM00959	LAML\|acute_myeloid_leukaemia	p.I175V (No)	GDSC	Talazoparib	1.6912
SIDM00959	LAML\|acute_myeloid_leukaemia	p.I175V (No)	GDSC	PARP_9495	1.5553
SIDM00959	LAML\|acute_myeloid_leukaemia	p.I175V (No)	GDSC	PARP_0108	0.1103
SIDM00959	LAML\|acute_myeloid_leukaemia	p.I175V (No)	GDSC	PARP_9482	0.0299
SIDM00959	LAML\|acute_myeloid_leukaemia	p.I175V (No)	GDSC	Olaparib	28.5357
SIDM00353	UNCLASSIFIED\|ovary	p.R290W (No)	GDSC	Olaparib	35.7024
SIDM00353	UNCLASSIFIED\|ovary	p.R290W (No)	GDSC	Veliparib	48.2454
SIDM00353	UNCLASSIFIED\|ovary	p.R290W (No)	GDSC	Rucaparib	40.3736
SIDM00353	UNCLASSIFIED\|ovary	p.R290W (No)	GDSC	Talazoparib	1.5376
SIDM00353	UNCLASSIFIED\|ovary	p.R290W (No)	GDSC	PARP_9495	3.5467
SIDM00353	UNCLASSIFIED\|ovary	p.R290W (No)	GDSC	PARP_0108	0.7871
SIDM00353	UNCLASSIFIED\|ovary	p.R290W (No)	GDSC	PARP_9482	0.2216
SIDM00353	UNCLASSIFIED\|ovary	p.R290W (No)	GDSC	Olaparib	17.9085
SIDM00353	UNCLASSIFIED\|ovary	p.R290W (No)	GDSC	Olaparib	405.89
SIDM00353	UNCLASSIFIED\|ovary	p.R290W (No)	GDSC	Niraparib	399.99
SIDM00353	UNCLASSIFIED\|ovary	p.R290W (No)	GDSC	Talazoparib	416.85
SIDM00617	LIHC\|liver	p.I285V (No)	GDSC	Olaparib	67.7867
SIDM00617	LIHC\|liver	p.I285V (No)	GDSC	Veliparib	72.3301
SIDM00617	LIHC\|liver	p.I285V (No)	GDSC	Rucaparib	48.0805
SIDM00617	LIHC\|liver	p.I285V (No)	GDSC	Talazoparib	13.3407
SIDM00617	LIHC\|liver	p.I285V (No)	GDSC	PARP_9495	4.9505
SIDM00617	LIHC\|liver	p.I285V (No)	GDSC	PARP_0108	0.7812
SIDM00617	LIHC\|liver	p.I285V (No)	GDSC	PARP_9482	0.7395
SIDM00617	LIHC\|liver	p.I285V (No)	GDSC	Olaparib	91.6175
SIDM00617	LIHC\|liver	p.I285V (No)	GDSC	Olaparib	253.84
SIDM00617	LIHC\|liver	p.I285V (No)	GDSC	Niraparib	118.26
SIDM00617	LIHC\|liver	p.I285V (No)	GDSC	Talazoparib	29.901
SIDM00045	STAD\|stomach	p.I175V (No)	GDSC	Olaparib	12.5373
SIDM00045	STAD\|stomach	p.I175V (No)	GDSC	Veliparib	29.1753
SIDM00045	STAD\|stomach	p.I175V (No)	GDSC	Rucaparib	32.9866
SIDM00045	STAD\|stomach	p.I175V (No)	GDSC	Talazoparib	28.0447
SIDM00045	STAD\|stomach	p.I175V (No)	GDSC	PARP_9495	9.9581
SIDM00045	STAD\|stomach	p.I175V (No)	GDSC	PARP_0108	3.7266
SIDM00045	STAD\|stomach	p.I175V (No)	GDSC	PARP_9482	3.8156
SIDM00045	STAD\|stomach	p.I175V (No)	GDSC	Olaparib	57.5065
SIDM00045	STAD\|stomach	p.I175V (No)	GDSC	Olaparib	45.102
SIDM00045	STAD\|stomach	p.I175V (No)	GDSC	Talazoparib	3.8376
SIDM01009	NB\|neuroblastoma	p.R322Q (No)	GDSC	Olaparib	12.1942
SIDM01009	NB\|neuroblastoma	p.R322Q (No)	GDSC	Veliparib	47.3323
SIDM01009	NB\|neuroblastoma	p.R322Q (No)	GDSC	Rucaparib	2.2647
SIDM01009	NB\|neuroblastoma	p.R322Q (No)	GDSC	Talazoparib	0.3827
SIDM01009	NB\|neuroblastoma	p.R322Q (No)	GDSC	PARP_9495	3.8477
SIDM01009	NB\|neuroblastoma	p.R322Q (No)	GDSC	PARP_0108	0.1481
SIDM01009	NB\|neuroblastoma	p.R322Q (No)	GDSC	PARP_9482	0.0766
SIDM01009	NB\|neuroblastoma	p.R322Q (No)	GDSC	Olaparib	13.5799
SIDM01009	NB\|neuroblastoma	p.R322Q (No)	GDSC	Olaparib	10.642
SIDM01009	NB\|neuroblastoma	p.R322Q (No)	GDSC	Niraparib	7.2913
SIDM01009	NB\|neuroblastoma	p.R322Q (No)	GDSC	Talazoparib	1.4657
SIDM00220	OV\|ovary	p.A85V (No)	GDSC	Olaparib	23.4786
SIDM00220	OV\|ovary	p.A85V (No)	GDSC	Veliparib	33.4218
SIDM00220	OV\|ovary	p.A85V (No)	GDSC	Rucaparib	9.8199
SIDM00220	OV\|ovary	p.A85V (No)	GDSC	Talazoparib	0.4039
SIDM00220	OV\|ovary	p.A85V (No)	GDSC	PARP_9495	1.1073
SIDM00220	OV\|ovary	p.A85V (No)	GDSC	PARP_0108	0.0597
SIDM00220	OV\|ovary	p.A85V (No)	GDSC	PARP_9482	0.0163
SIDM00220	OV\|ovary	p.A85V (No)	GDSC	Olaparib	10.8546
SIDM00220	OV\|ovary	p.A85V (No)	GDSC	Olaparib	37.486
SIDM00220	OV\|ovary	p.A85V (No)	GDSC	Talazoparib	1.7286
SIDM01020	MM\|myeloma	p.R290W (No)	GDSC	Olaparib	26.5823
SIDM01020	MM\|myeloma	p.R290W (No)	GDSC	Veliparib	30.148
SIDM01020	MM\|myeloma	p.R290W (No)	GDSC	Rucaparib	30.148
SIDM01020	MM\|myeloma	p.R290W (No)	GDSC	Olaparib	21.269
SIDM01020	MM\|myeloma	p.R290W (No)	GDSC	Niraparib	54.154
SIDM01020	MM\|myeloma	p.R290W (No)	GDSC	Talazoparib	34.015
SIDM00602	STAD\|stomach	p.G103R (No)	GDSC	Olaparib	71.6539
SIDM00602	STAD\|stomach	p.G103R (No)	GDSC	Veliparib	63.0985
SIDM00602	STAD\|stomach	p.G103R (No)	GDSC	Rucaparib	27.1929
SIDM00602	STAD\|stomach	p.G103R (No)	GDSC	PARP_9495	22.5502
SIDM00602	STAD\|stomach	p.G103R (No)	GDSC	PARP_0108	16.7048
SIDM00602	STAD\|stomach	p.G103R (No)	GDSC	PARP_9482	11.442
SIDM00602	STAD\|stomach	p.G103R (No)	GDSC	Olaparib	130.23
SIDM00602	STAD\|stomach	p.G103R (No)	GDSC	Niraparib	37.16
SIDM00602	STAD\|stomach	p.G103R (No)	GDSC	Talazoparib	91.453
SIDM00282	COREAD\|large_intestine	p.T218I (No)	GDSC	Olaparib	129.7192
SIDM00282	COREAD\|large_intestine	p.T218I (No)	GDSC	Veliparib	136.8174
SIDM00282	COREAD\|large_intestine	p.T218I (No)	GDSC	Rucaparib	95.4738
SIDM00282	COREAD\|large_intestine	p.T218I (No)	GDSC	Talazoparib	65.4633
SIDM00282	COREAD\|large_intestine	p.T218I (No)	GDSC	PARP_9495	12.7941
SIDM00282	COREAD\|large_intestine	p.T218I (No)	GDSC	PARP_0108	4.4096
SIDM00282	COREAD\|large_intestine	p.T218I (No)	GDSC	PARP_9482	5.5348
SIDM00282	COREAD\|large_intestine	p.T218I (No)	GDSC	Olaparib	254.0929
SIDM00282	COREAD\|large_intestine	p.T218I (No)	GDSC	Olaparib	184.75
SIDM00282	COREAD\|large_intestine	p.T218I (No)	GDSC	Niraparib	48.663
SIDM00282	COREAD\|large_intestine	p.T218I (No)	GDSC	Talazoparib	19.058
SIDM00676	BLCA\|bladder	p.R237Q (No)	GDSC	Olaparib	134.3751
SIDM00676	BLCA\|bladder	p.R237Q (No)	GDSC	Veliparib	130.652
SIDM00676	BLCA\|bladder	p.R237Q (No)	GDSC	Rucaparib	13.3244
SIDM00676	BLCA\|bladder	p.R237Q (No)	GDSC	Talazoparib	19.0194
SIDM00676	BLCA\|bladder	p.R237Q (No)	GDSC	PARP_9495	20.5913
SIDM00676	BLCA\|bladder	p.R237Q (No)	GDSC	PARP_0108	2.6761
SIDM00676	BLCA\|bladder	p.R237Q (No)	GDSC	PARP_9482	2.2424
SIDM00676	BLCA\|bladder	p.R237Q (No)	GDSC	Olaparib	28.3612
SIDM00676	BLCA\|bladder	p.R237Q (No)	GDSC	Olaparib	113.2
SIDM00676	BLCA\|bladder	p.R237Q (No)	GDSC	Niraparib	191.64
SIDM00676	BLCA\|bladder	p.R237Q (No)	GDSC	Talazoparib	63.208
SIDM00760	SCLC\|lung_small_cell_carcinoma	p.R322Q (No)	GDSC	Olaparib	46.3477
SIDM00760	SCLC\|lung_small_cell_carcinoma	p.R322Q (No)	GDSC	Veliparib	46.3477
SIDM00760	SCLC\|lung_small_cell_carcinoma	p.R322Q (No)	GDSC	Rucaparib	46.3467
SIDM00760	SCLC\|lung_small_cell_carcinoma	p.R322Q (No)	GDSC	Olaparib	62.319
SIDM00760	SCLC\|lung_small_cell_carcinoma	p.R322Q (No)	GDSC	Niraparib	41.045
SIDM00760	SCLC\|lung_small_cell_carcinoma	p.R322Q (No)	GDSC	Talazoparib	39.514
SIDM00375	HNSC\|head_and_neck	p.I175V (No)	GDSC	Olaparib	7.5974
SIDM00375	HNSC\|head_and_neck	p.I175V (No)	GDSC	Veliparib	25.8613
SIDM00375	HNSC\|head_and_neck	p.I175V (No)	GDSC	Rucaparib	18.8752
SIDM00375	HNSC\|head_and_neck	p.I175V (No)	GDSC	Talazoparib	8.217
SIDM00375	HNSC\|head_and_neck	p.I175V (No)	GDSC	PARP_9495	9.3696
SIDM00375	HNSC\|head_and_neck	p.I175V (No)	GDSC	PARP_0108	0.2286
SIDM00375	HNSC\|head_and_neck	p.I175V (No)	GDSC	PARP_9482	1.3047
SIDM00375	HNSC\|head_and_neck	p.I175V (No)	GDSC	Olaparib	31.6495
SIDM00375	HNSC\|head_and_neck	p.I175V (No)	GDSC	Olaparib	126.15
SIDM00375	HNSC\|head_and_neck	p.I175V (No)	GDSC	Niraparib	242.27
SIDM00375	HNSC\|head_and_neck	p.I175V (No)	GDSC	Talazoparib	65.109
SIDM00995	UNCLASSIFIED\|skin_other	p.P549S (No)	GDSC	Olaparib	46.1916
SIDM00995	UNCLASSIFIED\|skin_other	p.P549S (No)	GDSC	Veliparib	45.2325
SIDM00995	UNCLASSIFIED\|skin_other	p.P549S (No)	GDSC	Rucaparib	11.7879
SIDM00995	UNCLASSIFIED\|skin_other	p.P549S (No)	GDSC	Talazoparib	11.8816
SIDM00995	UNCLASSIFIED\|skin_other	p.P549S (No)	GDSC	PARP_9495	4.0421
SIDM00995	UNCLASSIFIED\|skin_other	p.P549S (No)	GDSC	PARP_0108	1.0504
SIDM00995	UNCLASSIFIED\|skin_other	p.P549S (No)	GDSC	PARP_9482	0.4521
SIDM00995	UNCLASSIFIED\|skin_other	p.P549S (No)	GDSC	Olaparib	12.0346
SIDM00990	UNCLASSIFIED\|lung_NSCLC_not_specified	p.C474R (No)	GDSC	Olaparib	101.7846
SIDM00990	UNCLASSIFIED\|lung_NSCLC_not_specified	p.C474R (No)	GDSC	Veliparib	3.4676
SIDM00990	UNCLASSIFIED\|lung_NSCLC_not_specified	p.C474R (No)	GDSC	Rucaparib	37.2405
SIDM00990	UNCLASSIFIED\|lung_NSCLC_not_specified	p.C474R (No)	GDSC	Talazoparib	158.7596
SIDM00990	UNCLASSIFIED\|lung_NSCLC_not_specified	p.C474R (No)	GDSC	PARP_9495	33.044
SIDM00990	UNCLASSIFIED\|lung_NSCLC_not_specified	p.C474R (No)	GDSC	PARP_0108	10.1053
SIDM00990	UNCLASSIFIED\|lung_NSCLC_not_specified	p.C474R (No)	GDSC	PARP_9482	6.7697
SIDM00990	UNCLASSIFIED\|lung_NSCLC_not_specified	p.C474R (No)	GDSC	Olaparib	162.0839
SIDM00789	COREAD\|large_intestine	p.H311Y (Yes)	GDSC	Olaparib	75.1104
SIDM00789	COREAD\|large_intestine	p.H311Y (Yes)	GDSC	Veliparib	93.7463
SIDM00789	COREAD\|large_intestine	p.H311Y (Yes)	GDSC	Rucaparib	70.6532
SIDM00789	COREAD\|large_intestine	p.H311Y (Yes)	GDSC	Talazoparib	21.7947
SIDM00789	COREAD\|large_intestine	p.H311Y (Yes)	GDSC	PARP_9495	29.466
SIDM00789	COREAD\|large_intestine	p.H311Y (Yes)	GDSC	PARP_0108	5.2485
SIDM00789	COREAD\|large_intestine	p.H311Y (Yes)	GDSC	PARP_9482	3.4084
SIDM00789	COREAD\|large_intestine	p.H311Y (Yes)	GDSC	Olaparib	85.178
SIDM00789	COREAD\|large_intestine	p.H311Y (Yes)	GDSC	Olaparib	136.22
SIDM00789	COREAD\|large_intestine	p.H311Y (Yes)	GDSC	Niraparib	22.225
SIDM00789	COREAD\|large_intestine	p.H311Y (Yes)	GDSC	Talazoparib	18.089
SIDM00834	COREAD\|large_intestine	p.S34P (No)	GDSC	Olaparib	221.236
SIDM00834	COREAD\|large_intestine	p.S34P (No)	GDSC	Veliparib	31.0771
SIDM00834	COREAD\|large_intestine	p.S34P (No)	GDSC	Rucaparib	361.7405
SIDM00834	COREAD\|large_intestine	p.S34P (No)	GDSC	Talazoparib	214.0484
SIDM00834	COREAD\|large_intestine	p.S34P (No)	GDSC	PARP_9495	119.4928
SIDM00834	COREAD\|large_intestine	p.S34P (No)	GDSC	PARP_0108	17.8354
SIDM00834	COREAD\|large_intestine	p.S34P (No)	GDSC	PARP_9482	17.8013
SIDM00834	COREAD\|large_intestine	p.S34P (No)	GDSC	Olaparib	353.391
SIDM00834	COREAD\|large_intestine	p.S34P (No)	GDSC	Olaparib	292.12
SIDM00834	COREAD\|large_intestine	p.S34P (No)	GDSC	Niraparib	237
SIDM00834	COREAD\|large_intestine	p.S34P (No)	GDSC	Talazoparib	33.938
SIDM00537	COREAD\|large_intestine	p.I382N (No)	GDSC	Olaparib	10.6217
SIDM00537	COREAD\|large_intestine	p.I382N (No)	GDSC	Veliparib	8.7647
SIDM00537	COREAD\|large_intestine	p.I382N (No)	GDSC	Rucaparib	54.5063
SIDM00537	COREAD\|large_intestine	p.I382N (No)	GDSC	Talazoparib	13.5323
SIDM00537	COREAD\|large_intestine	p.I382N (No)	GDSC	PARP_9495	10.6327
SIDM00537	COREAD\|large_intestine	p.I382N (No)	GDSC	PARP_0108	5.1544
SIDM00537	COREAD\|large_intestine	p.I382N (No)	GDSC	PARP_9482	3.3643
SIDM00537	COREAD\|large_intestine	p.I382N (No)	GDSC	Olaparib	85.4109
SIDM00537	COREAD\|large_intestine	p.I382N (No)	GDSC	Olaparib	131.61
SIDM00537	COREAD\|large_intestine	p.I382N (No)	GDSC	Niraparib	60.687
SIDM00537	COREAD\|large_intestine	p.I382N (No)	GDSC	Talazoparib	16.191
SIDM00450	LAML\|acute_myeloid_leukaemia	p.R290W (No)	GDSC	Olaparib	96.7569
SIDM00450	LAML\|acute_myeloid_leukaemia	p.R290W (No)	GDSC	Veliparib	96.7569
SIDM00450	LAML\|acute_myeloid_leukaemia	p.R290W (No)	GDSC	Rucaparib	79.2665
SIDM00450	LAML\|acute_myeloid_leukaemia	p.R290W (No)	GDSC	Talazoparib	168.4621
SIDM00450	LAML\|acute_myeloid_leukaemia	p.R290W (No)	GDSC	PARP_9495	60.1212
SIDM00450	LAML\|acute_myeloid_leukaemia	p.R290W (No)	GDSC	PARP_0108	6.4383
SIDM00450	LAML\|acute_myeloid_leukaemia	p.R290W (No)	GDSC	PARP_9482	4.8214
SIDM00450	LAML\|acute_myeloid_leukaemia	p.R290W (No)	GDSC	Olaparib	163.198
SIDM00374	DLBC\|B_cell_lymphoma	p.R290W (No)	GDSC	Olaparib	40.5614
SIDM00374	DLBC\|B_cell_lymphoma	p.R290W (No)	GDSC	Veliparib	55.1555
SIDM00374	DLBC\|B_cell_lymphoma	p.R290W (No)	GDSC	Rucaparib	54.3809
SIDM00374	DLBC\|B_cell_lymphoma	p.R290W (No)	GDSC	Talazoparib	11.9245
SIDM00374	DLBC\|B_cell_lymphoma	p.R290W (No)	GDSC	PARP_9495	14.9919
SIDM00374	DLBC\|B_cell_lymphoma	p.R290W (No)	GDSC	PARP_0108	1.5227
SIDM00374	DLBC\|B_cell_lymphoma	p.R290W (No)	GDSC	PARP_9482	1.4651
SIDM00374	DLBC\|B_cell_lymphoma	p.R290W (No)	GDSC	Olaparib	54.2204
SIDM00374	DLBC\|B_cell_lymphoma	p.R290W (No)	GDSC	Olaparib	76.627
SIDM00374	DLBC\|B_cell_lymphoma	p.R290W (No)	GDSC	Niraparib	7.958
SIDM00374	DLBC\|B_cell_lymphoma	p.R290W (No)	GDSC	Talazoparib	4.9188
SIDM00238	OV\|ovary	p.N481H (No)	GDSC	Olaparib	5.1446
SIDM00238	OV\|ovary	p.N481H (No)	GDSC	Veliparib	30.0106
SIDM00238	OV\|ovary	p.N481H (No)	GDSC	Rucaparib	25.1956
SIDM00238	OV\|ovary	p.N481H (No)	GDSC	Talazoparib	5.9816
SIDM00238	OV\|ovary	p.N481H (No)	GDSC	PARP_9495	6.4904
SIDM00238	OV\|ovary	p.N481H (No)	GDSC	PARP_0108	1.0445
SIDM00238	OV\|ovary	p.N481H (No)	GDSC	PARP_9482	0.6373
SIDM00238	OV\|ovary	p.N481H (No)	GDSC	Olaparib	23.0392
SIDM00238	OV\|ovary	p.N481H (No)	GDSC	Niraparib	140.78
SIDM00193	COREAD\|large_intestine	p.R290W (No)	GDSC	Olaparib	51.7143
SIDM00193	COREAD\|large_intestine	p.R290W (No)	GDSC	Veliparib	2.3121
SIDM00193	COREAD\|large_intestine	p.R290W (No)	GDSC	Rucaparib	50.4344
SIDM00193	COREAD\|large_intestine	p.R290W (No)	GDSC	Talazoparib	220.469
SIDM00193	COREAD\|large_intestine	p.R290W (No)	GDSC	PARP_9495	16.7782
SIDM00193	COREAD\|large_intestine	p.R290W (No)	GDSC	PARP_0108	7.216
SIDM00193	COREAD\|large_intestine	p.R290W (No)	GDSC	PARP_9482	8.9774
SIDM00193	COREAD\|large_intestine	p.R290W (No)	GDSC	Olaparib	32.7984
SIDM00193	COREAD\|large_intestine	p.R290W (No)	GDSC	Olaparib	38.522
SIDM00193	COREAD\|large_intestine	p.R290W (No)	GDSC	Niraparib	119.09
SIDM00118	COREAD\|large_intestine	p.R444* (No)	GDSC	Olaparib	38.9813
SIDM00118	COREAD\|large_intestine	p.R444* (No)	GDSC	Veliparib	62.4132
SIDM00118	COREAD\|large_intestine	p.R444* (No)	GDSC	Rucaparib	12.6666
SIDM00118	COREAD\|large_intestine	p.R444* (No)	GDSC	PARP_9495	3.1972
SIDM00118	COREAD\|large_intestine	p.R444* (No)	GDSC	PARP_0108	0.3281
SIDM00118	COREAD\|large_intestine	p.R444* (No)	GDSC	PARP_9482	0.5879
SIDM00118	COREAD\|large_intestine	p.R444* (No)	GDSC	Olaparib	42.9882
SIDM00118	COREAD\|large_intestine	p.R444* (No)	GDSC	Olaparib	46.464
SIDM00118	COREAD\|large_intestine	p.R444* (No)	GDSC	Niraparib	48.412
SIDM00118	COREAD\|large_intestine	p.R444* (No)	GDSC	Talazoparib	10.717
SIDM00661	DLBC\|B_cell_lymphoma	p.R13fs*10 (No)	GDSC	Olaparib	49.1928
SIDM00661	DLBC\|B_cell_lymphoma	p.R13fs*10 (No)	GDSC	Veliparib	36.6907
SIDM00661	DLBC\|B_cell_lymphoma	p.R13fs*10 (No)	GDSC	Rucaparib	56.521
SIDM00661	DLBC\|B_cell_lymphoma	p.R13fs*10 (No)	GDSC	Talazoparib	103.0965
SIDM00661	DLBC\|B_cell_lymphoma	p.R13fs*10 (No)	GDSC	PARP_9495	21.9005
SIDM00661	DLBC\|B_cell_lymphoma	p.R13fs*10 (No)	GDSC	PARP_0108	5.9566
SIDM00661	DLBC\|B_cell_lymphoma	p.R13fs*10 (No)	GDSC	PARP_9482	6.4068
SIDM00661	DLBC\|B_cell_lymphoma	p.R13fs*10 (No)	GDSC	Olaparib	68.5348

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: NEFYTRIP

Degron related mutations and impact score

Drug responses associated with PARP2 mutations

All proteins holding degron of NEFYTRIP

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UGN5	Poly [ADP-ribose] polymerase 2	CBL_PTK	303:310	NEFYTRIP	CBL	0.5031	More...