DegronMD - Q9UGP4(LIMD1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S296P	TCGA-AA-3715	COAD	TCGA	PRTPSVS	DEG_SCF_FBW7_1	292:298	Mutation altering degron motif	0.6752
p.S296P	DO8018	COAD	ICGC	PRTPSVS	DEG_SCF_FBW7_1	292:298	Mutation altering degron motif	0.6752
p.G359C	TCGA-AP-A0LN	UCEC	TCGA	APSSS	DEG_SPOP_SBC_1	349:353	Mutation rewiring degron network	0.1667
p.G359C	TCGA-DA-A1I1	SKCM	TCGA	APSSS	DEG_SPOP_SBC_1	349:353	Mutation rewiring degron network	0.1667
p.G359C	DO37966	SKCM	ICGC	APSSS	DEG_SPOP_SBC_1	349:353	Mutation rewiring degron network	0.1667
p.G359C	DO41614	UCEC	ICGC	APSSS	DEG_SPOP_SBC_1	349:353	Mutation rewiring degron network	0.1667
p.N282S	TCGA-AZ-4308	COAD	TCGA	PRTPSVS	DEG_SCF_FBW7_1	292:298	Mutation rewiring degron network	0.0556
p.N282S	DO8304	COAD	ICGC	PRTPSVS	DEG_SCF_FBW7_1	292:298	Mutation rewiring degron network	0.0556
p.S346F	TCGA-FW-A3R5	SKCM	TCGA	APSSS	DEG_SPOP_SBC_1	349:353	Mutation rewiring degron network	0.25
p.S346F	DO37406	SKCM	ICGC	APSSS	DEG_SPOP_SBC_1	349:353	Mutation rewiring degron network	0.25
p.S360L	TCGA-JX-A3Q0	CESC	TCGA	APSSS	DEG_SPOP_SBC_1	349:353	Mutation rewiring degron network	0.1389
p.S360L	DO51607	CESC	ICGC	APSSS	DEG_SPOP_SBC_1	349:353	Mutation rewiring degron network	0.1389
p.S347R	TCGA-MH-A561	KIRP	TCGA	APSSS	DEG_SPOP_SBC_1	349:353	Mutation rewiring degron network	0.2778
p.S347R	DO48509	KIRP	ICGC	APSSS	DEG_SPOP_SBC_1	349:353	Mutation rewiring degron network	0.2778
p.S296F	TCGA-ZF-AA51	BLCA	TCGA	PRTPSVS	DEG_SCF_FBW7_1	292:298	Mutation altering degron motif	0.7982
p.S296F	DO219093	BLCA	ICGC	PRTPSVS	DEG_SCF_FBW7_1	292:298	Mutation altering degron motif	0.7982
p.P306H	DO7388	CLLE	ICGC	PRTPSVS	DEG_SCF_FBW7_1	292:298	Mutation rewiring degron network	0.1111
p.G359R	DO223116	ESCA	ICGC	APSSS	DEG_SPOP_SBC_1	349:353	Mutation rewiring degron network	0.1667
p.P341S	DO233865	GACA	ICGC	APSSS	DEG_SPOP_SBC_1	349:353	Mutation rewiring degron network	0.1111
p.G340R	DO231708	LINC	ICGC	APSSS	DEG_SPOP_SBC_1	349:353	Mutation rewiring degron network	0.0833
p.A299T	DO229240	THCA	ICGC	PRTPSVS	DEG_SCF_FBW7_1	292:298	Mutation rewiring degron network	0.3056
p.A299T	SIDM01665	Colorectal Carcinoma	GDSC	PRTPSVS	DEG_SCF_FBW7_1	292:298	Mutation rewiring degron network	0.3056
p.A299T	ACH-000089	Colon/Colorectal Cancer	CCLE	PRTPSVS	DEG_SCF_FBW7_1	292:298	Mutation rewiring degron network	0.3056
p.G363D	SIDM00946	T-Lymphoblastic Leukemia	GDSC	APSSS	DEG_SPOP_SBC_1	349:353	Mutation rewiring degron network	0.0556
p.G363D	ACH-000981	Leukemia	CCLE	APSSS	DEG_SPOP_SBC_1	349:353	Mutation rewiring degron network	0.0556
p.G363D	DND-41	haematopoietic and lymphoid tissue	COSMIC	APSSS	DEG_SPOP_SBC_1	349:353	Mutation rewiring degron network	0.0556
p.V290F	SIDM01237	Hepatocellular Carcinoma	GDSC	PRTPSVS	DEG_SCF_FBW7_1	292:298	Mutation rewiring degron network	0.2778
p.V290F	ACH-001021	Liver Cancer	CCLE	PRTPSVS	DEG_SCF_FBW7_1	292:298	Mutation rewiring degron network	0.2778
p.V290F	C3A	liver	COSMIC	PRTPSVS	DEG_SCF_FBW7_1	292:298	Mutation rewiring degron network	0.2778
p.G359S	SIDM01183	Other Solid Cancers	GDSC	APSSS	DEG_SPOP_SBC_1	349:353	Mutation rewiring degron network	0.1667
p.G359S	ACH-001417	Lung Cancer	CCLE	APSSS	DEG_SPOP_SBC_1	349:353	Mutation rewiring degron network	0.1667
p.G359S	UMC-11	lung	COSMIC	APSSS	DEG_SPOP_SBC_1	349:353	Mutation rewiring degron network	0.1667
p.S343T	SIDM00889	Cervical Carcinoma	GDSC	APSSS	DEG_SPOP_SBC_1	349:353	Mutation rewiring degron network	0.1667
p.S343T	ACH-001333	Cervical Cancer	CCLE	APSSS	DEG_SPOP_SBC_1	349:353	Mutation rewiring degron network	0.1667
p.G356D	SIDM00150	Colorectal Carcinoma	GDSC	APSSS	DEG_SPOP_SBC_1	349:353	Mutation rewiring degron network	0.25
p.G356D	ACH-000969	Colon/Colorectal Cancer	CCLE	APSSS	DEG_SPOP_SBC_1	349:353	Mutation rewiring degron network	0.25
p.G356D	KM12	large intestine	COSMIC	APSSS	DEG_SPOP_SBC_1	349:353	Mutation rewiring degron network	0.25
p.S304T	SIDM01522	B-Lymphoblastic Leukemia	GDSC	PRTPSVS	DEG_SCF_FBW7_1	292:298	Mutation blocking phosphorylation signal	0.6111
p.S304T	ACH-000080	Leukemia	CCLE	PRTPSVS	DEG_SCF_FBW7_1	292:298	Mutation blocking phosphorylation signal	0.6111

Kaplan plot for LIMD1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

LIMD1

UniProt ID: Q9UGP4

Entrez ID: 8994

Protein name: LIM domain-containing protein 1

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for LIMD1 in