DegronMD

Uniprot ID: Q9UGP4

Source protein: LIM domain-containing protein 1

Source gene: LIMD1

Class: DEG_SCF_FBW7_1

Location: 292:298

E3 ligase: FBXW7

DEGRON score: 0.9872

ASA_SCORE: 84.8429

COIL: 0.9116

CONS_SCORE: 0.3255

DSS_SCORE: 0.5495

HELIX: 0.0243

FCONS_SCORE: 1.0637

RIG_SCORE: 0.6632

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S296P	TCGA-AA-3715	COAD	TCGA	PRTPSVS	DEG_SCF_FBW7_1	0.6752
p.S296P	DO8018	COAD	ICGC	PRTPSVS	DEG_SCF_FBW7_1	0.6752
p.N282S	TCGA-AZ-4308	COAD	TCGA	PRTPSVS	DEG_SCF_FBW7_1	0.0556
p.N282S	DO8304	COAD	ICGC	PRTPSVS	DEG_SCF_FBW7_1	0.0556
p.S296F	TCGA-ZF-AA51	BLCA	TCGA	PRTPSVS	DEG_SCF_FBW7_1	0.7982
p.S296F	DO219093	BLCA	ICGC	PRTPSVS	DEG_SCF_FBW7_1	0.7982
p.P306H	DO7388	CLLE	ICGC	PRTPSVS	DEG_SCF_FBW7_1	0.1111
p.A299T	DO229240	THCA	ICGC	PRTPSVS	DEG_SCF_FBW7_1	0.3056
p.A299T	SIDM01665	Colorectal Carcinoma	GDSC	PRTPSVS	DEG_SCF_FBW7_1	0.3056
p.A299T	ACH-000089	Colon/Colorectal Cancer	CCLE	PRTPSVS	DEG_SCF_FBW7_1	0.3056
p.V290F	SIDM01237	Hepatocellular Carcinoma	GDSC	PRTPSVS	DEG_SCF_FBW7_1	0.2778
p.V290F	ACH-001021	Liver Cancer	CCLE	PRTPSVS	DEG_SCF_FBW7_1	0.2778
p.V290F	C3A	liver	COSMIC	PRTPSVS	DEG_SCF_FBW7_1	0.2778
p.S304T	SIDM01522	B-Lymphoblastic Leukemia	GDSC	PRTPSVS	DEG_SCF_FBW7_1	0.6111
p.S304T	ACH-000080	Leukemia	CCLE	PRTPSVS	DEG_SCF_FBW7_1	0.6111

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UGP4	LIM domain-containing protein 1	DEG_SCF_FBW7_1	292:298	PRTPSVS	FBXW7	0.9872	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons