DegronMD - Q9UGP5(POLL)

POLL

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L7F	TCGA-78-8640	LUAD	TCGA	RQKIHAD	LIG_APCC_ABBAyCdc20_2	13:19	Mutation blocking ubiquitination signal	0.6111
p.L7F	DO45340	LUAD	ICGC	RQKIHAD	LIG_APCC_ABBAyCdc20_2	13:19	Mutation blocking ubiquitination signal	0.6111
p.L11Q	DO23526	LIRI	ICGC	RQKIHAD	LIG_APCC_ABBAyCdc20_2	13:19	Mutation rewiring degron network	0.2778
p.S8L	DO229255	LMS	ICGC	RQKIHAD	LIG_APCC_ABBAyCdc20_2	13:19	Mutation substituting flanking lysine	0.3056
p.R9K	DO36556	READ	ICGC	RQKIHAD	LIG_APCC_ABBAyCdc20_2	13:19	Mutation rewiring degron network	0.2222
p.P29S	SIDM00737	Non-Small Cell Lung Carcinoma	GDSC	RQKIHAD	LIG_APCC_ABBAyCdc20_2	13:19	Mutation rewiring degron network	0.0556
p.P29S	ACH-000904	Lung Cancer	CCLE	RQKIHAD	LIG_APCC_ABBAyCdc20_2	13:19	Mutation rewiring degron network	0.0556
p.P29S	ACH-001362	Lung Cancer	CCLE	RQKIHAD	LIG_APCC_ABBAyCdc20_2	13:19	Mutation rewiring degron network	0.0556
p.P29S	NCI-H1770	lung	COSMIC	RQKIHAD	LIG_APCC_ABBAyCdc20_2	13:19	Mutation rewiring degron network	0.0556
p.K15Q	ACH-001623	Brain Cancer	CCLE	RQKIHAD	LIG_APCC_ABBAyCdc20_2	13:19	Mutation altering degron motif	0.5833
p.P13R	NCI-H1651	lung	COSMIC	RQKIHAD	LIG_APCC_ABBAyCdc20_2	13:19	Mutation altering degron motif	0.7512

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*NOTE: the Kaplan plots were collected from OncoLnc