DegronMD

Uniprot ID: Q9UGP5

Source protein: DNA polymerase lambda

Source gene: POLL

Class: LIG_APCC_ABBAyCdc20_2

Location: 13:19

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9501

ASA_SCORE: 110.1571

COIL: 0.796

CONS_SCORE: 0.3778

DSS_SCORE: 0.4225

HELIX: 0.1306

FCONS_SCORE: 0.9938

RIG_SCORE: 0.7216

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L7F	TCGA-78-8640	LUAD	TCGA	RQKIHAD	LIG_APCC_ABBAyCdc20_2	0.6111
p.L7F	DO45340	LUAD	ICGC	RQKIHAD	LIG_APCC_ABBAyCdc20_2	0.6111
p.L11Q	DO23526	LIRI	ICGC	RQKIHAD	LIG_APCC_ABBAyCdc20_2	0.2778
p.S8L	DO229255	LMS	ICGC	RQKIHAD	LIG_APCC_ABBAyCdc20_2	0.3056
p.R9K	DO36556	READ	ICGC	RQKIHAD	LIG_APCC_ABBAyCdc20_2	0.2222
p.P29S	SIDM00737	Non-Small Cell Lung Carcinoma	GDSC	RQKIHAD	LIG_APCC_ABBAyCdc20_2	0.0556
p.P29S	ACH-000904	Lung Cancer	CCLE	RQKIHAD	LIG_APCC_ABBAyCdc20_2	0.0556
p.P29S	ACH-001362	Lung Cancer	CCLE	RQKIHAD	LIG_APCC_ABBAyCdc20_2	0.0556
p.P29S	NCI-H1770	lung	COSMIC	RQKIHAD	LIG_APCC_ABBAyCdc20_2	0.0556
p.K15Q	ACH-001623	Brain Cancer	CCLE	RQKIHAD	LIG_APCC_ABBAyCdc20_2	0.5833
p.P13R	NCI-H1651	lung	COSMIC	RQKIHAD	LIG_APCC_ABBAyCdc20_2	0.7512

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UGP5	DNA polymerase lambda	LIG_APCC_ABBAyCdc20_2	13:19	RQKIHAD	APC,CDC20,FZR1	0.9501	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons