DegronMD - Q9UH90(FBXO40)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P120L	TCGA-21-1079	LUSC	TCGA	MKETPSEE	DEG_SCF_FBW7_2	116:123	Mutation altering degron motif	0.7582
p.P120L	DO26846	LUSC	ICGC	MKETPSEE	DEG_SCF_FBW7_2	116:123	Mutation altering degron motif	0.7582
p.D133N	TCGA-25-2391	OV	TCGA	MKETPSEE	DEG_SCF_FBW7_2	116:123	Mutation rewiring degron network	0.0556
p.D133N	DO31769	OV	ICGC	MKETPSEE	DEG_SCF_FBW7_2	116:123	Mutation rewiring degron network	0.0556
p.P120S	TCGA-EB-A6R0	SKCM	TCGA	MKETPSEE	DEG_SCF_FBW7_2	116:123	Mutation altering degron motif	0.6752
p.P120S	DO48646	SKCM	ICGC	MKETPSEE	DEG_SCF_FBW7_2	116:123	Mutation altering degron motif	0.6752
p.A128V	TCGA-ER-A19G	SKCM	TCGA	MKETPSEE	DEG_SCF_FBW7_2	116:123	Mutation rewiring degron network	0.1944
p.A128V	DO47284	SKCM	ICGC	MKETPSEE	DEG_SCF_FBW7_2	116:123	Mutation rewiring degron network	0.1944
p.E108K	TCGA-FS-A1ZC	SKCM	TCGA	MKETPSEE	DEG_SCF_FBW7_2	116:123	Mutation rewiring degron network	0.1111
p.E108K	DO37487	SKCM	ICGC	MKETPSEE	DEG_SCF_FBW7_2	116:123	Mutation rewiring degron network	0.1111
p.A128S	DO222646	BTCA	ICGC	MKETPSEE	DEG_SCF_FBW7_2	116:123	Mutation rewiring degron network	0.1944
p.M116I	DO222647	MELA	ICGC	MKETPSEE	DEG_SCF_FBW7_2	116:123	Mutation altering degron motif	0.6507
p.A128T	DO222662	MELA	ICGC	MKETPSEE	DEG_SCF_FBW7_2	116:123	Mutation rewiring degron network	0.1944
p.D106G	DO232761	PBCA	ICGC	MKETPSEE	DEG_SCF_FBW7_2	116:123	Mutation rewiring degron network	0.0556
p.S107Y	SIDM00744	Non-Small Cell Lung Carcinoma	GDSC	MKETPSEE	DEG_SCF_FBW7_2	116:123	Mutation rewiring degron network	0.0833
p.S107Y	ACH-000893	Lung Cancer	CCLE	MKETPSEE	DEG_SCF_FBW7_2	116:123	Mutation rewiring degron network	0.0833
p.S107Y	NCI-H1651	lung	COSMIC	MKETPSEE	DEG_SCF_FBW7_2	116:123	Mutation rewiring degron network	0.0833

Kaplan plot for FBXO40 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

FBXO40

UniProt ID: Q9UH90

Entrez ID: 51725

Protein name: F-box only protein 40 (Muscle disease-related protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for FBXO40 in