DegronMD

Uniprot ID: Q9UH90

Source protein: F-box only protein 40

Source gene: FBXO40

Class: DEG_SCF_FBW7_2

Location: 116:123

E3 ligase: FBXW7

DEGRON score: 0.5767

ASA_SCORE: 102.2125

COIL: 0.8158

CONS_SCORE: 0.4608

DSS_SCORE: 0.4198

HELIX: 0.1375

FCONS_SCORE: 0.7882

RIG_SCORE: 0.7627

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P120L	TCGA-21-1079	LUSC	TCGA	MKETPSEE	DEG_SCF_FBW7_2	0.7582
p.P120L	DO26846	LUSC	ICGC	MKETPSEE	DEG_SCF_FBW7_2	0.7582
p.D133N	TCGA-25-2391	OV	TCGA	MKETPSEE	DEG_SCF_FBW7_2	0.0556
p.D133N	DO31769	OV	ICGC	MKETPSEE	DEG_SCF_FBW7_2	0.0556
p.P120S	TCGA-EB-A6R0	SKCM	TCGA	MKETPSEE	DEG_SCF_FBW7_2	0.6752
p.P120S	DO48646	SKCM	ICGC	MKETPSEE	DEG_SCF_FBW7_2	0.6752
p.A128V	TCGA-ER-A19G	SKCM	TCGA	MKETPSEE	DEG_SCF_FBW7_2	0.1944
p.A128V	DO47284	SKCM	ICGC	MKETPSEE	DEG_SCF_FBW7_2	0.1944
p.E108K	TCGA-FS-A1ZC	SKCM	TCGA	MKETPSEE	DEG_SCF_FBW7_2	0.1111
p.E108K	DO37487	SKCM	ICGC	MKETPSEE	DEG_SCF_FBW7_2	0.1111
p.A128S	DO222646	BTCA	ICGC	MKETPSEE	DEG_SCF_FBW7_2	0.1944
p.M116I	DO222647	MELA	ICGC	MKETPSEE	DEG_SCF_FBW7_2	0.6507
p.A128T	DO222662	MELA	ICGC	MKETPSEE	DEG_SCF_FBW7_2	0.1944
p.D106G	DO232761	PBCA	ICGC	MKETPSEE	DEG_SCF_FBW7_2	0.0556
p.S107Y	SIDM00744	Non-Small Cell Lung Carcinoma	GDSC	MKETPSEE	DEG_SCF_FBW7_2	0.0833
p.S107Y	ACH-000893	Lung Cancer	CCLE	MKETPSEE	DEG_SCF_FBW7_2	0.0833
p.S107Y	NCI-H1651	lung	COSMIC	MKETPSEE	DEG_SCF_FBW7_2	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UH90	F-box only protein 40	DEG_SCF_FBW7_2	116:123	MKETPSEE	FBXW7	0.5767	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons