DegronMD - Q9UHF4(IL20RA)

FUNCTION: The IL20RA/IL20RB dimer is a receptor for IL19, IL20 and IL24. The IL20RA/IL10RB dimer is a receptor for IL26.

GO - Biological processes (BP): cytokine-mediated signaling pathway [GO:0019221]; positive regulation of intrinsic apoptotic signaling pathway [GO:2001244]; regulation of bone resorption [GO:0045124]

GO - Molecular function (MF): cytokine receptor activity [GO:0004896]; interleukin-20 binding [GO:0042015]

GO - Cellular component (CC): integral component of plasma membrane [GO:0005887]; plasma membrane [GO:0005886]

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.I369F	DO222817	BTCA	ICGC	MEIFCD	LIG_APCC_ABBA_1	367:372	Mutation altering degron motif	0.7415
p.T367A	SUP-HD1	haematopoietic and lymphoid tissue	COSMIC	MEIFCD	LIG_APCC_ABBA_1	367:372	Mutation altering degron motif	0.7139
p.W371L	DO23474	LINC	ICGC	MEIFCD	LIG_APCC_ABBA_1	367:372	Mutation altering degron motif	0.7015
p.M367I	TCGA-EE-A17Z	SKCM	TCGA	MEIFCD	LIG_APCC_ABBA_1	367:372	Mutation altering degron motif	0.6507
p.E368K	TCGA-EB-A41A	SKCM	TCGA	MEIFCD	LIG_APCC_ABBA_1	367:372	Mutation altering degron motif	0.591
p.E368K	DO222595	MELA	ICGC	MEIFCD	LIG_APCC_ABBA_1	367:372	Mutation altering degron motif	0.591
p.E368K	DO229502	SKCA	ICGC	MEIFCD	LIG_APCC_ABBA_1	367:372	Mutation altering degron motif	0.591
p.E368K	DO37429	SKCM	ICGC	MEIFCD	LIG_APCC_ABBA_1	367:372	Mutation altering degron motif	0.591
p.E366K	PCI-30	upper aerodigestive tract	COSMIC	MEIFCD	LIG_APCC_ABBA_1	367:372	Mutation rewiring degron network	0.3056
p.E374A	DO229475	SKCA	ICGC	MEIFCD	LIG_APCC_ABBA_1	367:372	Mutation rewiring degron network	0.2778
p.S364L	SIDM00297	Non-Small Cell Lung Carcinoma	GDSC	MEIFCD	LIG_APCC_ABBA_1	367:372	Mutation rewiring degron network	0.25
p.S364L	ACH-002157	Lung Cancer	CCLE	MEIFCD	LIG_APCC_ABBA_1	367:372	Mutation rewiring degron network	0.25
p.S364L	LC-2-ad	lung	COSMIC	MEIFCD	LIG_APCC_ABBA_1	367:372	Mutation rewiring degron network	0.25
p.E375K	ACH-000740	Head and Neck Cancer	CCLE	MEIFCD	LIG_APCC_ABBA_1	367:372	Mutation rewiring degron network	0.25
p.E375K	ACH-002388	Skin Cancer	CCLE	MEIFCD	LIG_APCC_ABBA_1	367:372	Mutation rewiring degron network	0.25
p.E375K	A253	salivary gland	COSMIC	MEIFCD	LIG_APCC_ABBA_1	367:372	Mutation rewiring degron network	0.25
p.G364R	Jurkat	haematopoietic and lymphoid tissue	COSMIC	MEIFCD	LIG_APCC_ABBA_1	367:372	Mutation rewiring degron network	0.25
p.A363V	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	MEIFCD	LIG_APCC_ABBA_1	367:372	Mutation rewiring degron network	0.2222
p.A363V	GR-ST	haematopoietic and lymphoid tissue	COSMIC	MEIFCD	LIG_APCC_ABBA_1	367:372	Mutation rewiring degron network	0.2222
p.E362D	DO50021	BRCA	ICGC	MEIFCD	LIG_APCC_ABBA_1	367:372	Mutation rewiring degron network	0.1944

Showing 1 to 20 of 32 entries

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Kaplan plot for IL20RA in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

IL20RA

UniProt ID: Q9UHF4

Entrez ID: 53832

Protein name: Interleukin-20 receptor subunit alpha (IL-20 receptor subunit alpha) (IL-20R-alpha) (IL-20RA) (Cytokine receptor class-II member 8) (Cytokine receptor family 2 member 8) (CRF2-8) (IL-20R1) (ZcytoR7)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for IL20RA in