DegronMD

Uniprot ID: Q9UHF4

Source protein: Interleukin-20 receptor subunit alpha

Source gene: IL20RA

Class: LIG_APCC_ABBA_1

Location: 367:372

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6893

ASA_SCORE: 79.15

COIL: 0.6038

CONS_SCORE: 0.3459

DSS_SCORE: 0.5026

HELIX: 0.2887

FCONS_SCORE: 1.1026

RIG_SCORE: 0.8076

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G361E	TCGA-05-4417	LUAD	TCGA	MEIFCD	LIG_APCC_ABBA_1	0.1667
p.S381Y	TCGA-AA-3510	COAD	TCGA	MEIFCD	LIG_APCC_ABBA_1	0.0833
p.G379D	TCGA-DU-6407	LGG	TCGA	MEIFCD	LIG_APCC_ABBA_1	0.1389
p.E368K	TCGA-EB-A41A	SKCM	TCGA	MEIFCD	LIG_APCC_ABBA_1	0.591
p.E368K	DO222595	MELA	ICGC	MEIFCD	LIG_APCC_ABBA_1	0.591
p.E368K	DO229502	SKCA	ICGC	MEIFCD	LIG_APCC_ABBA_1	0.591
p.E368K	DO37429	SKCM	ICGC	MEIFCD	LIG_APCC_ABBA_1	0.591
p.M367I	TCGA-EE-A17Z	SKCM	TCGA	MEIFCD	LIG_APCC_ABBA_1	0.6507
p.E362D	DO50021	BRCA	ICGC	MEIFCD	LIG_APCC_ABBA_1	0.1944
p.I369F	DO222817	BTCA	ICGC	MEIFCD	LIG_APCC_ABBA_1	0.7415
p.L382F	DO229005	COCA	ICGC	MEIFCD	LIG_APCC_ABBA_1	0.0556
p.C379Y	DO233792	GACA	ICGC	MEIFCD	LIG_APCC_ABBA_1	0.1389
p.H359R	DO233869	GACA	ICGC	MEIFCD	LIG_APCC_ABBA_1	0.1111
p.W371L	DO23474	LINC	ICGC	MEIFCD	LIG_APCC_ABBA_1	0.7015
p.E374A	DO229475	SKCA	ICGC	MEIFCD	LIG_APCC_ABBA_1	0.2778
p.G359V	DO38328	STAD	ICGC	MEIFCD	LIG_APCC_ABBA_1	0.1111
p.S382L	DO50078	UCEC	ICGC	MEIFCD	LIG_APCC_ABBA_1	0.0556
p.Y362C	SIDM00962	Chronic Myelogenous Leukemia	GDSC	MEIFCD	LIG_APCC_ABBA_1	0.1944
p.Y362C	BV-173	haematopoietic_and_lymphoid_tissue	COSMIC	MEIFCD	LIG_APCC_ABBA_1	0.1944
p.S364L	SIDM00297	Non-Small Cell Lung Carcinoma	GDSC	MEIFCD	LIG_APCC_ABBA_1	0.25
p.S364L	ACH-002157	Lung Cancer	CCLE	MEIFCD	LIG_APCC_ABBA_1	0.25
p.S364L	LC-2-ad	lung	COSMIC	MEIFCD	LIG_APCC_ABBA_1	0.25
p.E375K	ACH-000740	Head and Neck Cancer	CCLE	MEIFCD	LIG_APCC_ABBA_1	0.25
p.E375K	ACH-002388	Skin Cancer	CCLE	MEIFCD	LIG_APCC_ABBA_1	0.25
p.E375K	A253	salivary_gland	COSMIC	MEIFCD	LIG_APCC_ABBA_1	0.25
p.A363V	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	MEIFCD	LIG_APCC_ABBA_1	0.2222
p.A363V	GR-ST	haematopoietic_and_lymphoid_tissue	COSMIC	MEIFCD	LIG_APCC_ABBA_1	0.2222
p.G364R	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	MEIFCD	LIG_APCC_ABBA_1	0.25
p.T367A	SUP-HD1	haematopoietic_and_lymphoid_tissue	COSMIC	MEIFCD	LIG_APCC_ABBA_1	0.7139
p.E366K	PCI-30	upper_aerodigestive_tract	COSMIC	MEIFCD	LIG_APCC_ABBA_1	0.3056
p.P381H	CML-T1	haematopoietic_and_lymphoid_tissue	COSMIC	MEIFCD	LIG_APCC_ABBA_1	0.0833
p.P360T	HAL-01	haematopoietic_and_lymphoid_tissue	COSMIC	MEIFCD	LIG_APCC_ABBA_1	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: MEIFCD

Degron related mutations and impact score

Drug responses associated with IL20RA mutations

All proteins holding degron of MEIFCD

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UHF4	Interleukin-20 receptor subunit alpha	LIG_APCC_ABBA_1	367:372	MEIFCD	APC,CDC20,FZR1	0.6893	More...