DegronMD

Uniprot ID: Q9UHF4

Source protein: Interleukin-20 receptor subunit alpha

Source gene: IL20RA

Class: LIG_APCC_ABBA_1

Location: 367:372

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6893

ASA_SCORE: 79.15

COIL: 0.6038

CONS_SCORE: 0.3459

DSS_SCORE: 0.5026

HELIX: 0.2887

FCONS_SCORE: 1.1026

RIG_SCORE: 0.8076

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I369F	DO222817	BTCA	ICGC	MEIFCD	LIG_APCC_ABBA_1	0.7415
p.T367A	SUP-HD1	haematopoietic_and_lymphoid_tissue	COSMIC	MEIFCD	LIG_APCC_ABBA_1	0.7139
p.W371L	DO23474	LINC	ICGC	MEIFCD	LIG_APCC_ABBA_1	0.7015
p.M367I	TCGA-EE-A17Z	SKCM	TCGA	MEIFCD	LIG_APCC_ABBA_1	0.6507
p.E368K	TCGA-EB-A41A	SKCM	TCGA	MEIFCD	LIG_APCC_ABBA_1	0.591
p.E368K	DO222595	MELA	ICGC	MEIFCD	LIG_APCC_ABBA_1	0.591
p.E368K	DO229502	SKCA	ICGC	MEIFCD	LIG_APCC_ABBA_1	0.591
p.E368K	DO37429	SKCM	ICGC	MEIFCD	LIG_APCC_ABBA_1	0.591
p.E366K	PCI-30	upper_aerodigestive_tract	COSMIC	MEIFCD	LIG_APCC_ABBA_1	0.3056
p.E374A	DO229475	SKCA	ICGC	MEIFCD	LIG_APCC_ABBA_1	0.2778
p.S364L	SIDM00297	Non-Small Cell Lung Carcinoma	GDSC	MEIFCD	LIG_APCC_ABBA_1	0.25
p.S364L	ACH-002157	Lung Cancer	CCLE	MEIFCD	LIG_APCC_ABBA_1	0.25
p.S364L	LC-2-ad	lung	COSMIC	MEIFCD	LIG_APCC_ABBA_1	0.25
p.E375K	ACH-000740	Head and Neck Cancer	CCLE	MEIFCD	LIG_APCC_ABBA_1	0.25
p.E375K	ACH-002388	Skin Cancer	CCLE	MEIFCD	LIG_APCC_ABBA_1	0.25
p.E375K	A253	salivary_gland	COSMIC	MEIFCD	LIG_APCC_ABBA_1	0.25
p.G364R	Jurkat	haematopoietic_and_lymphoid_tissue	COSMIC	MEIFCD	LIG_APCC_ABBA_1	0.25
p.A363V	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	MEIFCD	LIG_APCC_ABBA_1	0.2222
p.A363V	GR-ST	haematopoietic_and_lymphoid_tissue	COSMIC	MEIFCD	LIG_APCC_ABBA_1	0.2222
p.E362D	DO50021	BRCA	ICGC	MEIFCD	LIG_APCC_ABBA_1	0.1944
p.Y362C	SIDM00962	Chronic Myelogenous Leukemia	GDSC	MEIFCD	LIG_APCC_ABBA_1	0.1944
p.Y362C	BV-173	haematopoietic_and_lymphoid_tissue	COSMIC	MEIFCD	LIG_APCC_ABBA_1	0.1944
p.G361E	TCGA-05-4417	LUAD	TCGA	MEIFCD	LIG_APCC_ABBA_1	0.1667
p.G379D	TCGA-DU-6407	LGG	TCGA	MEIFCD	LIG_APCC_ABBA_1	0.1389
p.C379Y	DO233792	GACA	ICGC	MEIFCD	LIG_APCC_ABBA_1	0.1389

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Drug responses associated with IL20RA mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of MEIFCD

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UHF4	Interleukin-20 receptor subunit alpha	LIG_APCC_ABBA_1	367:372	MEIFCD	APC,CDC20,FZR1	0.6893	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: MEIFCD

Degron related mutations and impact score

Drug responses associated with IL20RA mutations

All proteins holding degron of MEIFCD