DegronMD - Q9UHF5(IL17B)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R34W	TCGA-A2-A0D3	BRCA	TCGA	LAPGPHQVPLDL	DEG_ODPH_VHL_1	38:49	Mutation rewiring degron network	0.2222
p.R34W	TCGA-B6-A0I8	BRCA	TCGA	LAPGPHQVPLDL	DEG_ODPH_VHL_1	38:49	Mutation rewiring degron network	0.2222
p.R34W	DO3488	BRCA	ICGC	LAPGPHQVPLDL	DEG_ODPH_VHL_1	38:49	Mutation rewiring degron network	0.2222
p.R34W	DO2149	BRCA	ICGC	LAPGPHQVPLDL	DEG_ODPH_VHL_1	38:49	Mutation rewiring degron network	0.2222
p.R34W	SIDM01966	Colorectal Carcinoma	GDSC	LAPGPHQVPLDL	DEG_ODPH_VHL_1	38:49	Mutation rewiring degron network	0.2222
p.K30N	TCGA-BF-A1PU	SKCM	TCGA	LAPGPHQVPLDL	DEG_ODPH_VHL_1	38:49	Mutation substituting flanking lysine	0.2222
p.K30N	DO50278	SKCM	ICGC	LAPGPHQVPLDL	DEG_ODPH_VHL_1	38:49	Mutation substituting flanking lysine	0.2222
p.K30N	SIDM00846	Cervical Carcinoma	GDSC	LAPGPHQVPLDL	DEG_ODPH_VHL_1	38:49	Mutation substituting flanking lysine	0.2222
p.K30N	ACH-001086	Cervical Cancer	CCLE	LAPGPHQVPLDL	DEG_ODPH_VHL_1	38:49	Mutation substituting flanking lysine	0.2222
p.K30N	HeLa	cervix	COSMIC	LAPGPHQVPLDL	DEG_ODPH_VHL_1	38:49	Mutation substituting flanking lysine	0.2222
p.P40T	TCGA-CD-A4MG	STAD	TCGA	LAPGPHQVPLDL	DEG_ODPH_VHL_1	38:49	Mutation altering degron motif	0.7031
p.P40T	DO48009	STAD	ICGC	LAPGPHQVPLDL	DEG_ODPH_VHL_1	38:49	Mutation altering degron motif	0.7031
p.R58H	TCGA-DU-6392	LGG	TCGA	LAPGPHQVPLDL	DEG_ODPH_VHL_1	38:49	Mutation rewiring degron network	0.0833
p.R58H	DO227549	COCA	ICGC	LAPGPHQVPLDL	DEG_ODPH_VHL_1	38:49	Mutation rewiring degron network	0.0833
p.R58H	DO22237	LGG	ICGC	LAPGPHQVPLDL	DEG_ODPH_VHL_1	38:49	Mutation rewiring degron network	0.0833
p.R52W	TCGA-UZ-A9Q1	KIRP	TCGA	LAPGPHQVPLDL	DEG_ODPH_VHL_1	38:49	Mutation rewiring degron network	0.25
p.R52W	DO219716	KIRP	ICGC	LAPGPHQVPLDL	DEG_ODPH_VHL_1	38:49	Mutation rewiring degron network	0.25
p.R29K	DO222557	MELA	ICGC	LAPGPHQVPLDL	DEG_ODPH_VHL_1	38:49	Mutation rewiring degron network	0.0833
p.R52G	SIDM00734	Non-Small Cell Lung Carcinoma	GDSC	LAPGPHQVPLDL	DEG_ODPH_VHL_1	38:49	Mutation rewiring degron network	0.25
p.R52G	ACH-000589	Lung Cancer	CCLE	LAPGPHQVPLDL	DEG_ODPH_VHL_1	38:49	Mutation rewiring degron network	0.25
p.R52G	NCI-H1437	lung	COSMIC	LAPGPHQVPLDL	DEG_ODPH_VHL_1	38:49	Mutation rewiring degron network	0.25
p.P46Q	ACH-001369	Ovarian Cancer	CCLE	LAPGPHQVPLDL	DEG_ODPH_VHL_1	38:49	Mutation altering degron motif	0.5924

Kaplan plot for IL17B in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

IL17B

UniProt ID: Q9UHF5

Entrez ID: 27190

Protein name: Interleukin-17B (IL-17B) (Cytokine Zcyto7) (Interleukin-20) (IL-20) (Neuronal interleukin-17-related factor)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for IL17B in