DegronMD

Uniprot ID: Q9UHF5

Source protein: Interleukin-17B

Source gene: IL17B

Class: DEG_ODPH_VHL_1

Location: 38:49

E3 ligase: VHL

DEGRON score: 0.9822

ASA_SCORE: 70.0083

COIL: 0.7528

CONS_SCORE: 0.5647

DSS_SCORE: 0.6473

HELIX: 0.2117

FCONS_SCORE: 1.031

RIG_SCORE: 0.6378

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R34W	TCGA-A2-A0D3	BRCA	TCGA	LAPGPHQVPLDL	DEG_ODPH_VHL_1	0.2222
p.R34W	TCGA-B6-A0I8	BRCA	TCGA	LAPGPHQVPLDL	DEG_ODPH_VHL_1	0.2222
p.R34W	DO3488	BRCA	ICGC	LAPGPHQVPLDL	DEG_ODPH_VHL_1	0.2222
p.R34W	DO2149	BRCA	ICGC	LAPGPHQVPLDL	DEG_ODPH_VHL_1	0.2222
p.R34W	SIDM01966	Colorectal Carcinoma	GDSC	LAPGPHQVPLDL	DEG_ODPH_VHL_1	0.2222
p.K30N	TCGA-BF-A1PU	SKCM	TCGA	LAPGPHQVPLDL	DEG_ODPH_VHL_1	0.2222
p.K30N	DO50278	SKCM	ICGC	LAPGPHQVPLDL	DEG_ODPH_VHL_1	0.2222
p.K30N	SIDM00846	Cervical Carcinoma	GDSC	LAPGPHQVPLDL	DEG_ODPH_VHL_1	0.2222
p.K30N	ACH-001086	Cervical Cancer	CCLE	LAPGPHQVPLDL	DEG_ODPH_VHL_1	0.2222
p.K30N	HeLa	cervix	COSMIC	LAPGPHQVPLDL	DEG_ODPH_VHL_1	0.2222
p.P40T	TCGA-CD-A4MG	STAD	TCGA	LAPGPHQVPLDL	DEG_ODPH_VHL_1	0.7031
p.P40T	DO48009	STAD	ICGC	LAPGPHQVPLDL	DEG_ODPH_VHL_1	0.7031
p.R58H	TCGA-DU-6392	LGG	TCGA	LAPGPHQVPLDL	DEG_ODPH_VHL_1	0.0833
p.R58H	DO227549	COCA	ICGC	LAPGPHQVPLDL	DEG_ODPH_VHL_1	0.0833
p.R58H	DO22237	LGG	ICGC	LAPGPHQVPLDL	DEG_ODPH_VHL_1	0.0833
p.R52W	TCGA-UZ-A9Q1	KIRP	TCGA	LAPGPHQVPLDL	DEG_ODPH_VHL_1	0.25
p.R52W	DO219716	KIRP	ICGC	LAPGPHQVPLDL	DEG_ODPH_VHL_1	0.25
p.R29K	DO222557	MELA	ICGC	LAPGPHQVPLDL	DEG_ODPH_VHL_1	0.0833
p.R52G	SIDM00734	Non-Small Cell Lung Carcinoma	GDSC	LAPGPHQVPLDL	DEG_ODPH_VHL_1	0.25
p.R52G	ACH-000589	Lung Cancer	CCLE	LAPGPHQVPLDL	DEG_ODPH_VHL_1	0.25
p.R52G	NCI-H1437	lung	COSMIC	LAPGPHQVPLDL	DEG_ODPH_VHL_1	0.25
p.P46Q	ACH-001369	Ovarian Cancer	CCLE	LAPGPHQVPLDL	DEG_ODPH_VHL_1	0.5924

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UHF5	Interleukin-17B	DEG_ODPH_VHL_1	38:49	LAPGPHQVPLDL	VHL	0.9822	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons