ADGRE2
UniProt ID: Q9UHX3
Entrez ID: 30817
Protein name: Adhesion G protein-coupled receptor E2 (EGF-like module receptor 2) (EGF-like module-containing mucin-like hormone receptor-like 2) (CD antigen CD312)
External links: UniprotKB HGNC RefSeq COSMIC
Please click HERE
for better display.
FUNCTION: Cell surface receptor that binds to the chondroitin sulfate moiety of glycosaminoglycan chains and promotes cell attachment. Promotes granulocyte chemotaxis, degranulation and adhesion. In macrophages, promotes the release of inflammatory cytokines, including IL8 and TNF. Signals probably ...
FUNCTION: Cell surface receptor that binds to the chondroitin sulfate moiety of glycosaminoglycan chains and promotes cell attachment. Promotes granulocyte chemotaxis, degranulation and adhesion. In macrophages, promotes the release of inflammatory cytokines, including IL8 and TNF. Signals probably through G-proteins. Is a regulator of mast cell degranulation (PubMed:26841242). {ECO:0000269|PubMed:12829604, ECO:0000269|PubMed:17928360, ECO:0000269|PubMed:22310662, ECO:0000269|PubMed:22575658, ECO:0000269|PubMed:26841242}.
View more >>
GO - Biological processes (BP):
adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cell adhesion [GO:0007155]; cell migration [GO:0016477]; cell surface receptor signaling pathway [GO:0007166]; G protein-coupled receptor signaling pathway [GO:0007186]; granulocyte chemotaxis [GO:0071621]; infla...
adenylate cyclase-activating G protein-coupled receptor signaling pathway [GO:0007189]; cell adhesion [GO:0007155]; cell migration [GO:0016477]; cell surface receptor signaling pathway [GO:0007166]; G protein-coupled receptor signaling pathway [GO:0007186]; granulocyte chemotaxis [GO:0071621]; inflammatory response [GO:0006954]; regulation of mast cell degranulation [GO:0043304]
View more >>
GO - Molecular function (MF):
calcium ion binding [GO:0005509]; chondroitin sulfate binding [GO:0035374]; G protein-coupled receptor activity [GO:0004930]...
calcium ion binding [GO:0005509]; chondroitin sulfate binding [GO:0035374]; G protein-coupled receptor activity [GO:0004930]
View more >>
GO - Cellular component (CC):
integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; leading edge membrane [GO:0031256]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587]...
integral component of membrane [GO:0016021]; integral component of plasma membrane [GO:0005887]; leading edge membrane [GO:0031256]; plasma membrane [GO:0005886]; ruffle membrane [GO:0032587]
View more >>
ADGRE2
Control panel
Show dataset:
Show Degron:
All sites
Degron
Degron
Filter mutation sites
All sites
Minimum 5 samples
Minimum 10 samples
Minimum 5 samples
Minimum 10 samples
Data table is loading....
Kaplan plot for ADGRE2 in
Download patient class data (Lower:Upper = 50%:50%)
*NOTE: the Kaplan plots were collected from OncoLnc