DegronMD

Uniprot ID: Q9UHX3

Source protein: Adhesion G protein-coupled receptor E2

Source gene: ADGRE2

Class: LIG_APCC_ABBA_1

Location: 481:486

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6529

ASA_SCORE: 13.9667

COIL: 0.1143

CONS_SCORE: 0.5454

DSS_SCORE: 0.0782

HELIX: 0.0068

FCONS_SCORE: 1.4305

RIG_SCORE: 0.9313

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V480M	SIDM00867	Glioblastoma	GDSC	LCVFWE	LIG_APCC_ABBA_1	0.3056
p.V480M	DBTRG-05MG	central_nervous_system	COSMIC	LCVFWE	LIG_APCC_ABBA_1	0.3056
p.V486M	SNU-449	liver	COSMIC	LCVFWE	LIG_APCC_ABBA_1	0.7208
p.V486M	VMRC-MELG	skin	COSMIC	LCVFWE	LIG_APCC_ABBA_1	0.7208
p.R487W	CML-T1	haematopoietic_and_lymphoid_tissue	COSMIC	LCVFWE	LIG_APCC_ABBA_1	0.3056
p.V477M	SNU-449	liver	COSMIC	LCVFWE	LIG_APCC_ABBA_1	0.2222
p.V477M	VMRC-MELG	skin	COSMIC	LCVFWE	LIG_APCC_ABBA_1	0.2222
p.L495M	ETK-1	biliary_tract	COSMIC	LCVFWE	LIG_APCC_ABBA_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UHX3	Adhesion G protein-coupled receptor E2	LIG_APCC_ABBA_1	481:486	LCVFWE	APC,CDC20,FZR1	0.6529	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons