DegronMD - Q9UI08(EVL)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R12L	TCGA-BQ-7059	KIRP	TCGA	VMVYDD	LIG_APCC_ABBA_1	13:18	Mutation rewiring degron network	0.3056
p.R12L	DO20932	KIRP	ICGC	VMVYDD	LIG_APCC_ABBA_1	13:18	Mutation rewiring degron network	0.3056
p.W25C	TCGA-EE-A2MG	SKCM	TCGA	VMVYDD	LIG_APCC_ABBA_1	13:18	Mutation rewiring degron network	0.1389
p.W25C	DO37421	SKCM	ICGC	VMVYDD	LIG_APCC_ABBA_1	13:18	Mutation rewiring degron network	0.1389
p.T21A	DO233699	GACA	ICGC	VMVYDD	LIG_APCC_ABBA_1	13:18	Mutation substituting flanking lysine	0.3611
p.S22I	DO228952	LICA	ICGC	VMVYDD	LIG_APCC_ABBA_1	13:18	Mutation substituting flanking lysine	0.3333
p.V17F	DO229019	LICA	ICGC	VMVYDD	LIG_APCC_ABBA_1	13:18	Mutation altering degron motif	0.7068
p.V15A	SIDM00217	Colorectal Carcinoma	GDSC	VMVYDD	LIG_APCC_ABBA_1	13:18	Mutation altering degron motif	0.6936
p.V15A	ACH-000999	Colon/Colorectal Cancer	CCLE	VMVYDD	LIG_APCC_ABBA_1	13:18	Mutation altering degron motif	0.6936
p.V15A	SNU-1040	large intestine	COSMIC	VMVYDD	LIG_APCC_ABBA_1	13:18	Mutation altering degron motif	0.6936
p.D20N	SIDM00145	T-Lymphoblastic Leukemia	GDSC	VMVYDD	LIG_APCC_ABBA_1	13:18	Mutation blocking phosphorylation signal	0.7222
p.D20N	ACH-001127	Leukemia	CCLE	VMVYDD	LIG_APCC_ABBA_1	13:18	Mutation blocking phosphorylation signal	0.7222
p.D20N	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	VMVYDD	LIG_APCC_ABBA_1	13:18	Mutation blocking phosphorylation signal	0.7222
p.A11S	SIDM00721	Small Cell Lung Carcinoma	GDSC	VMVYDD	LIG_APCC_ABBA_1	13:18	Mutation rewiring degron network	0.2778
p.A11S	ACH-002171	Lung Cancer	CCLE	VMVYDD	LIG_APCC_ABBA_1	13:18	Mutation rewiring degron network	0.2778
p.A11S	NCI-H250	lung	COSMIC	VMVYDD	LIG_APCC_ABBA_1	13:18	Mutation rewiring degron network	0.2778
p.V13A	SNU-1040	large intestine	COSMIC	VMVYDD	LIG_APCC_ABBA_1	13:18	Mutation altering degron motif	0.6936
p.K27N	CW-2	large intestine	COSMIC	VMVYDD	LIG_APCC_ABBA_1	13:18	Mutation blocking ubiquitination signal	0.5278
p.P28S	SU-DHL-8	NS	COSMIC	VMVYDD	LIG_APCC_ABBA_1	13:18	Mutation rewiring degron network	0.0556
p.A9S	NCI-H250	lung	COSMIC	VMVYDD	LIG_APCC_ABBA_1	13:18	Mutation rewiring degron network	0.2222
p.D24N	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	VMVYDD	LIG_APCC_ABBA_1	13:18	Mutation rewiring degron network	0.1667
p.A15S	NCI-H250	lung	COSMIC	VMVYDD	LIG_APCC_ABBA_1	13:18	Mutation altering degron motif	0.7588
p.V19A	SNU-1040	large intestine	COSMIC	VMVYDD	LIG_APCC_ABBA_1	13:18	Mutation rewiring degron network	0.3056
p.D18N	MOLT-4	haematopoietic and lymphoid tissue	COSMIC	VMVYDD	LIG_APCC_ABBA_1	13:18	Mutation altering degron motif	0.6932

Kaplan plot for EVL in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

EVL

UniProt ID: Q9UI08

Entrez ID: 51466

Protein name: Ena/VASP-like protein (Ena/vasodilator-stimulated phosphoprotein-like)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for EVL in