DegronMD

Uniprot ID: Q9UI08

Source protein: Ena/VASP-like protein

Source gene: EVL

Class: LIG_APCC_ABBA_1

Location: 13:18

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6155

ASA_SCORE: 28.2833

COIL: 0.1783

CONS_SCORE: 0.637

DSS_SCORE: 0.2239

HELIX: 0.0077

FCONS_SCORE: 1.259

RIG_SCORE: 0.815

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R12L	TCGA-BQ-7059	KIRP	TCGA	VMVYDD	LIG_APCC_ABBA_1	0.3056
p.R12L	DO20932	KIRP	ICGC	VMVYDD	LIG_APCC_ABBA_1	0.3056
p.W25C	TCGA-EE-A2MG	SKCM	TCGA	VMVYDD	LIG_APCC_ABBA_1	0.1389
p.W25C	DO37421	SKCM	ICGC	VMVYDD	LIG_APCC_ABBA_1	0.1389
p.T21A	DO233699	GACA	ICGC	VMVYDD	LIG_APCC_ABBA_1	0.3611
p.S22I	DO228952	LICA	ICGC	VMVYDD	LIG_APCC_ABBA_1	0.3333
p.V17F	DO229019	LICA	ICGC	VMVYDD	LIG_APCC_ABBA_1	0.7068
p.V15A	SIDM00217	Colorectal Carcinoma	GDSC	VMVYDD	LIG_APCC_ABBA_1	0.6936
p.V15A	ACH-000999	Colon/Colorectal Cancer	CCLE	VMVYDD	LIG_APCC_ABBA_1	0.6936
p.V15A	SNU-1040	large_intestine	COSMIC	VMVYDD	LIG_APCC_ABBA_1	0.6936
p.D20N	SIDM00145	T-Lymphoblastic Leukemia	GDSC	VMVYDD	LIG_APCC_ABBA_1	0.7222
p.D20N	ACH-001127	Leukemia	CCLE	VMVYDD	LIG_APCC_ABBA_1	0.7222
p.D20N	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	VMVYDD	LIG_APCC_ABBA_1	0.7222
p.A11S	SIDM00721	Small Cell Lung Carcinoma	GDSC	VMVYDD	LIG_APCC_ABBA_1	0.2778
p.A11S	ACH-002171	Lung Cancer	CCLE	VMVYDD	LIG_APCC_ABBA_1	0.2778
p.A11S	NCI-H250	lung	COSMIC	VMVYDD	LIG_APCC_ABBA_1	0.2778
p.V13A	SNU-1040	large_intestine	COSMIC	VMVYDD	LIG_APCC_ABBA_1	0.6936
p.K27N	CW-2	large_intestine	COSMIC	VMVYDD	LIG_APCC_ABBA_1	0.5278
p.P28S	SU-DHL-8	NS	COSMIC	VMVYDD	LIG_APCC_ABBA_1	0.0556
p.A9S	NCI-H250	lung	COSMIC	VMVYDD	LIG_APCC_ABBA_1	0.2222
p.D24N	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	VMVYDD	LIG_APCC_ABBA_1	0.1667
p.A15S	NCI-H250	lung	COSMIC	VMVYDD	LIG_APCC_ABBA_1	0.7588
p.V19A	SNU-1040	large_intestine	COSMIC	VMVYDD	LIG_APCC_ABBA_1	0.3056
p.D18N	MOLT-4	haematopoietic_and_lymphoid_tissue	COSMIC	VMVYDD	LIG_APCC_ABBA_1	0.6932

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UI08	Ena/VASP-like protein	LIG_APCC_ABBA_1	13:18	VMVYDD	APC,CDC20,FZR1	0.6155	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VMVYDD

Degron related mutations and impact score

Drug responses associated with EVL mutations

All proteins holding degron of VMVYDD