DegronMD - Q9UI46(DNAI1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R468T	TCGA-98-A539	LUSC	TCGA	RKLVHID	LIG_APCC_ABBAyCdc20_2	468:474	Mutation altering degron motif	0.7876
p.R468T	DO52022	LUSC	ICGC	RKLVHID	LIG_APCC_ABBAyCdc20_2	468:474	Mutation altering degron motif	0.7876
p.I460M	TCGA-AX-A05Z	UCEC	TCGA	RKLVHID	LIG_APCC_ABBAyCdc20_2	468:474	Mutation rewiring degron network	0.1111
p.I460M	DO40884	UCEC	ICGC	RKLVHID	LIG_APCC_ABBAyCdc20_2	468:474	Mutation rewiring degron network	0.1111
p.R459M	TCGA-DF-A2KN	UCEC	TCGA	RKLVHID	LIG_APCC_ABBAyCdc20_2	468:474	Mutation rewiring degron network	0.0833
p.R459M	DO223282	UCEC	ICGC	RKLVHID	LIG_APCC_ABBAyCdc20_2	468:474	Mutation rewiring degron network	0.0833
p.S483I	DO229034	LICA	ICGC	RKLVHID	LIG_APCC_ABBAyCdc20_2	468:474	Mutation rewiring degron network	0.0833
p.R459S	DO229037	LICA	ICGC	RKLVHID	LIG_APCC_ABBAyCdc20_2	468:474	Mutation rewiring degron network	0.0833
p.V470L	SIDM00250	Esophageal Squamous Cell Carcinoma	GDSC	RKLVHID	LIG_APCC_ABBAyCdc20_2	468:474	Mutation altering degron motif	0.6765
p.V470L	TE-4	oesophagus	COSMIC	RKLVHID	LIG_APCC_ABBAyCdc20_2	468:474	Mutation altering degron motif	0.6765
p.G462S	SIDM00208	Glioblastoma	GDSC	RKLVHID	LIG_APCC_ABBAyCdc20_2	468:474	Mutation rewiring degron network	0.1667
p.G462S	D-502MG	central nervous system	COSMIC	RKLVHID	LIG_APCC_ABBAyCdc20_2	468:474	Mutation rewiring degron network	0.1667
p.V466L	ACH-000917	Esophageal Cancer	CCLE	RKLVHID	LIG_APCC_ABBAyCdc20_2	468:474	Mutation rewiring degron network	0.2778
p.V466L	TE-4	oesophagus	COSMIC	RKLVHID	LIG_APCC_ABBAyCdc20_2	468:474	Mutation rewiring degron network	0.2778
p.G458S	ACH-002229	Brain Cancer	CCLE	RKLVHID	LIG_APCC_ABBAyCdc20_2	468:474	Mutation rewiring degron network	0.0556
p.G458S	D-502MG	central nervous system	COSMIC	RKLVHID	LIG_APCC_ABBAyCdc20_2	468:474	Mutation rewiring degron network	0.0556
p.E481K	SW684	soft tissue	COSMIC	RKLVHID	LIG_APCC_ABBAyCdc20_2	468:474	Mutation rewiring degron network	0.1389

Kaplan plot for DNAI1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

DNAI1

UniProt ID: Q9UI46

Entrez ID: 27019

Protein name: Dynein axonemal intermediate chain 1 (Axonemal dynein intermediate chain 1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for DNAI1 in