DegronMD

Uniprot ID: Q9UI46

Source protein: Dynein axonemal intermediate chain 1

Source gene: DNAI1

Class: LIG_APCC_ABBAyCdc20_2

Location: 468:474

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9125

ASA_SCORE: 78.7

COIL: 0.5559

CONS_SCORE: 0.4093

DSS_SCORE: 0.0349

HELIX: 0.0351

FCONS_SCORE: 0.816

RIG_SCORE: 0.9376

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R468T	TCGA-98-A539	LUSC	TCGA	RKLVHID	LIG_APCC_ABBAyCdc20_2	0.7876
p.R468T	DO52022	LUSC	ICGC	RKLVHID	LIG_APCC_ABBAyCdc20_2	0.7876
p.I460M	TCGA-AX-A05Z	UCEC	TCGA	RKLVHID	LIG_APCC_ABBAyCdc20_2	0.1111
p.I460M	DO40884	UCEC	ICGC	RKLVHID	LIG_APCC_ABBAyCdc20_2	0.1111
p.R459M	TCGA-DF-A2KN	UCEC	TCGA	RKLVHID	LIG_APCC_ABBAyCdc20_2	0.0833
p.R459M	DO223282	UCEC	ICGC	RKLVHID	LIG_APCC_ABBAyCdc20_2	0.0833
p.S483I	DO229034	LICA	ICGC	RKLVHID	LIG_APCC_ABBAyCdc20_2	0.0833
p.R459S	DO229037	LICA	ICGC	RKLVHID	LIG_APCC_ABBAyCdc20_2	0.0833
p.V470L	SIDM00250	Esophageal Squamous Cell Carcinoma	GDSC	RKLVHID	LIG_APCC_ABBAyCdc20_2	0.6765
p.V470L	TE-4	oesophagus	COSMIC	RKLVHID	LIG_APCC_ABBAyCdc20_2	0.6765
p.G462S	SIDM00208	Glioblastoma	GDSC	RKLVHID	LIG_APCC_ABBAyCdc20_2	0.1667
p.G462S	D-502MG	central_nervous_system	COSMIC	RKLVHID	LIG_APCC_ABBAyCdc20_2	0.1667
p.V466L	ACH-000917	Esophageal Cancer	CCLE	RKLVHID	LIG_APCC_ABBAyCdc20_2	0.2778
p.V466L	TE-4	oesophagus	COSMIC	RKLVHID	LIG_APCC_ABBAyCdc20_2	0.2778
p.G458S	ACH-002229	Brain Cancer	CCLE	RKLVHID	LIG_APCC_ABBAyCdc20_2	0.0556
p.G458S	D-502MG	central_nervous_system	COSMIC	RKLVHID	LIG_APCC_ABBAyCdc20_2	0.0556
p.E481K	SW684	soft_tissue	COSMIC	RKLVHID	LIG_APCC_ABBAyCdc20_2	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UI46	Dynein axonemal intermediate chain 1	LIG_APCC_ABBAyCdc20_2	468:474	RKLVHID	APC,CDC20,FZR1	0.9125	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons