DegronMD - Q9UII4(HERC5)

HERC5

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.E348K	TCGA-BH-A0HP	BRCA	TCGA	TRDQLMPLP	DEG_APCC_DBOX_1	333:341	Mutation rewiring degron network	0.1389
p.E348K	DO1755	BRCA	ICGC	TRDQLMPLP	DEG_APCC_DBOX_1	333:341	Mutation rewiring degron network	0.1389
p.S345L	TCGA-D7-8572	STAD	TCGA	TRDQLMPLP	DEG_APCC_DBOX_1	333:341	Mutation rewiring degron network	0.2222
p.S345L	DO47735	STAD	ICGC	TRDQLMPLP	DEG_APCC_DBOX_1	333:341	Mutation rewiring degron network	0.2222
p.E340D	DO48566	BLCA	ICGC	TRDQLMPLP	DEG_APCC_DBOX_1	333:341	Mutation altering degron motif	0.6758
p.D343H	DO2401	BRCA	ICGC	TRDQLMPLP	DEG_APCC_DBOX_1	333:341	Mutation rewiring degron network	0.2778
p.R334H	DO233089	GACA	ICGC	TRDQLMPLP	DEG_APCC_DBOX_1	333:341	Mutation altering degron motif	0.8244
p.G329V	DO233819	GACA	ICGC	TRDQLMPLP	DEG_APCC_DBOX_1	333:341	Mutation rewiring degron network	0.2222
p.M338I	DO229045	LICA	ICGC	TRDQLMPLP	DEG_APCC_DBOX_1	333:341	Mutation altering degron motif	0.6507
p.D335Y	DO229008	LICA	ICGC	TRDQLMPLP	DEG_APCC_DBOX_1	333:341	Mutation altering degron motif	0.6214
p.K346T	DO36556	READ	ICGC	TRDQLMPLP	DEG_APCC_DBOX_1	333:341	Mutation rewiring degron network	0.1944
p.R324I	DO50144	STAD	ICGC	TRDQLMPLP	DEG_APCC_DBOX_1	333:341	Mutation blocking ubiquitination signal	0.5278
p.R334S	SIDM00727	Non-Small Cell Lung Carcinoma	GDSC	TRDQLMPLP	DEG_APCC_DBOX_1	333:341	Mutation altering degron motif	0.7427
p.R334S	ACH-000951	Lung Cancer	CCLE	TRDQLMPLP	DEG_APCC_DBOX_1	333:341	Mutation altering degron motif	0.7427
p.R334S	NCI-H2342	lung	COSMIC	TRDQLMPLP	DEG_APCC_DBOX_1	333:341	Mutation altering degron motif	0.7427

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*NOTE: the Kaplan plots were collected from OncoLnc