DegronMD

Uniprot ID: Q9UII4

Source protein: E3 ISG15--protein ligase HERC5

Source gene: HERC5

Class: DEG_APCC_DBOX_1

Location: 333:341

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8636

ASA_SCORE: 86.6667

COIL: 0.7106

CONS_SCORE: 0.4288

DSS_SCORE: 0.5389

HELIX: 0.1017

FCONS_SCORE: 1.1747

RIG_SCORE: 0.7461

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E348K	TCGA-BH-A0HP	BRCA	TCGA	TRDQLMPLP	DEG_APCC_DBOX_1	0.1389
p.E348K	DO1755	BRCA	ICGC	TRDQLMPLP	DEG_APCC_DBOX_1	0.1389
p.S345L	TCGA-D7-8572	STAD	TCGA	TRDQLMPLP	DEG_APCC_DBOX_1	0.2222
p.S345L	DO47735	STAD	ICGC	TRDQLMPLP	DEG_APCC_DBOX_1	0.2222
p.E340D	DO48566	BLCA	ICGC	TRDQLMPLP	DEG_APCC_DBOX_1	0.6758
p.D343H	DO2401	BRCA	ICGC	TRDQLMPLP	DEG_APCC_DBOX_1	0.2778
p.R334H	DO233089	GACA	ICGC	TRDQLMPLP	DEG_APCC_DBOX_1	0.8244
p.G329V	DO233819	GACA	ICGC	TRDQLMPLP	DEG_APCC_DBOX_1	0.2222
p.M338I	DO229045	LICA	ICGC	TRDQLMPLP	DEG_APCC_DBOX_1	0.6507
p.D335Y	DO229008	LICA	ICGC	TRDQLMPLP	DEG_APCC_DBOX_1	0.6214
p.K346T	DO36556	READ	ICGC	TRDQLMPLP	DEG_APCC_DBOX_1	0.1944
p.R324I	DO50144	STAD	ICGC	TRDQLMPLP	DEG_APCC_DBOX_1	0.5278
p.R334S	SIDM00727	Non-Small Cell Lung Carcinoma	GDSC	TRDQLMPLP	DEG_APCC_DBOX_1	0.7427
p.R334S	ACH-000951	Lung Cancer	CCLE	TRDQLMPLP	DEG_APCC_DBOX_1	0.7427
p.R334S	NCI-H2342	lung	COSMIC	TRDQLMPLP	DEG_APCC_DBOX_1	0.7427

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UII4	E3 ISG15--protein ligase HERC5	DEG_APCC_DBOX_1	333:341	TRDQLMPLP	APC,CDC20,FZR1	0.8636	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons