DegronMD - Q9UIL1(SCOC)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R30Q	TCGA-DD-AACT	LIHC	TCGA	CRGQLVQVS	DEG_APCC_DBOX_1	35:43	Mutation rewiring degron network	0.1944
p.R30Q	DO219563	LIHC	ICGC	CRGQLVQVS	DEG_APCC_DBOX_1	35:43	Mutation rewiring degron network	0.1944
p.A49T	TCGA-F4-6570	COAD	TCGA	CRGQLVQVS	DEG_APCC_DBOX_1	35:43	Mutation rewiring degron network	0.1667
p.A49T	DO10443	COAD	ICGC	CRGQLVQVS	DEG_APCC_DBOX_1	35:43	Mutation rewiring degron network	0.1667
p.S34N	TCGA-SJ-A6ZI	UCEC	TCGA	CRGQLVQVS	DEG_APCC_DBOX_1	35:43	Mutation rewiring degron network	0.3056
p.S34N	DO219784	UCEC	ICGC	CRGQLVQVS	DEG_APCC_DBOX_1	35:43	Mutation rewiring degron network	0.3056
p.S53L	DO2401	BRCA	ICGC	CRGQLVQVS	DEG_APCC_DBOX_1	35:43	Mutation rewiring degron network	0.0556
p.S53P	DO8858	COAD	ICGC	CRGQLVQVS	DEG_APCC_DBOX_1	35:43	Mutation rewiring degron network	0.0556
p.R28I	DO8842	COAD	ICGC	CRGQLVQVS	DEG_APCC_DBOX_1	35:43	Mutation rewiring degron network	0.1389
p.R28I	DO41020	UCEC	ICGC	CRGQLVQVS	DEG_APCC_DBOX_1	35:43	Mutation rewiring degron network	0.1389
p.R28I	DO43041	UCEC	ICGC	CRGQLVQVS	DEG_APCC_DBOX_1	35:43	Mutation rewiring degron network	0.1389
p.R28I	HCC2998	large intestine	COSMIC	CRGQLVQVS	DEG_APCC_DBOX_1	35:43	Mutation rewiring degron network	0.1389
p.V42L	DO229010	COCA	ICGC	CRGQLVQVS	DEG_APCC_DBOX_1	35:43	Mutation altering degron motif	0.5654
p.V42L	DO229013	COCA	ICGC	CRGQLVQVS	DEG_APCC_DBOX_1	35:43	Mutation altering degron motif	0.5654
p.V42L	DO229505	LAML	ICGC	CRGQLVQVS	DEG_APCC_DBOX_1	35:43	Mutation altering degron motif	0.5654
p.V42L	DO228941	LICA	ICGC	CRGQLVQVS	DEG_APCC_DBOX_1	35:43	Mutation altering degron motif	0.5654
p.V42L	DO228947	LICA	ICGC	CRGQLVQVS	DEG_APCC_DBOX_1	35:43	Mutation altering degron motif	0.5654
p.P39T	DO15695	HNSC	ICGC	CRGQLVQVS	DEG_APCC_DBOX_1	35:43	Mutation altering degron motif	0.7031
p.L30F	DO228900	LICA	ICGC	CRGQLVQVS	DEG_APCC_DBOX_1	35:43	Mutation rewiring degron network	0.1944
p.R36L	DO228974	LICA	ICGC	CRGQLVQVS	DEG_APCC_DBOX_1	35:43	Mutation altering degron motif	0.8428
p.D36N	DO220878	MELA	ICGC	CRGQLVQVS	DEG_APCC_DBOX_1	35:43	Mutation altering degron motif	0.6932
p.S26F	DO51278	SKCM	ICGC	CRGQLVQVS	DEG_APCC_DBOX_1	35:43	Mutation rewiring degron network	0.0833

Kaplan plot for SCOC in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SCOC

UniProt ID: Q9UIL1

Entrez ID: 60592

Protein name: Short coiled-coil protein

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SCOC in