DegronMD

Uniprot ID: Q9UIL1

Source protein: Short coiled-coil protein

Source gene: SCOC

Class: DEG_APCC_DBOX_1

Location: 35:43

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.946

ASA_SCORE: 79.2778

COIL: 0.664

CONS_SCORE: 0.1922

DSS_SCORE: 0.3776

HELIX: 0.044

FCONS_SCORE: 0.8564

RIG_SCORE: 0.7552

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R30Q	TCGA-DD-AACT	LIHC	TCGA	CRGQLVQVS	DEG_APCC_DBOX_1	0.1944
p.R30Q	DO219563	LIHC	ICGC	CRGQLVQVS	DEG_APCC_DBOX_1	0.1944
p.A49T	TCGA-F4-6570	COAD	TCGA	CRGQLVQVS	DEG_APCC_DBOX_1	0.1667
p.A49T	DO10443	COAD	ICGC	CRGQLVQVS	DEG_APCC_DBOX_1	0.1667
p.S34N	TCGA-SJ-A6ZI	UCEC	TCGA	CRGQLVQVS	DEG_APCC_DBOX_1	0.3056
p.S34N	DO219784	UCEC	ICGC	CRGQLVQVS	DEG_APCC_DBOX_1	0.3056
p.S53L	DO2401	BRCA	ICGC	CRGQLVQVS	DEG_APCC_DBOX_1	0.0556
p.S53P	DO8858	COAD	ICGC	CRGQLVQVS	DEG_APCC_DBOX_1	0.0556
p.R28I	DO8842	COAD	ICGC	CRGQLVQVS	DEG_APCC_DBOX_1	0.1389
p.R28I	DO41020	UCEC	ICGC	CRGQLVQVS	DEG_APCC_DBOX_1	0.1389
p.R28I	DO43041	UCEC	ICGC	CRGQLVQVS	DEG_APCC_DBOX_1	0.1389
p.R28I	HCC2998	large_intestine	COSMIC	CRGQLVQVS	DEG_APCC_DBOX_1	0.1389
p.V42L	DO229010	COCA	ICGC	CRGQLVQVS	DEG_APCC_DBOX_1	0.5654
p.V42L	DO229013	COCA	ICGC	CRGQLVQVS	DEG_APCC_DBOX_1	0.5654
p.V42L	DO229505	LAML	ICGC	CRGQLVQVS	DEG_APCC_DBOX_1	0.5654
p.V42L	DO228941	LICA	ICGC	CRGQLVQVS	DEG_APCC_DBOX_1	0.5654
p.V42L	DO228947	LICA	ICGC	CRGQLVQVS	DEG_APCC_DBOX_1	0.5654
p.P39T	DO15695	HNSC	ICGC	CRGQLVQVS	DEG_APCC_DBOX_1	0.7031
p.L30F	DO228900	LICA	ICGC	CRGQLVQVS	DEG_APCC_DBOX_1	0.1944
p.R36L	DO228974	LICA	ICGC	CRGQLVQVS	DEG_APCC_DBOX_1	0.8428
p.D36N	DO220878	MELA	ICGC	CRGQLVQVS	DEG_APCC_DBOX_1	0.6932
p.S26F	DO51278	SKCM	ICGC	CRGQLVQVS	DEG_APCC_DBOX_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UIL1	Short coiled-coil protein	DEG_APCC_DBOX_1	35:43	CRGQLVQVS	APC,CDC20,FZR1	0.946	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons