DegronMD - Q9UJ68(MSRA)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R56I	TCGA-06-5416	GBM	TCGA	VEPFPE	LIG_APCC_ABBA_1	58:63	Mutation rewiring degron network	0.2778
p.R56I	DO10880	GBM	ICGC	VEPFPE	LIG_APCC_ABBA_1	58:63	Mutation rewiring degron network	0.2778
p.M72I	TCGA-17-Z018	LUAD	TCGA	VEPFPE	LIG_APCC_ABBA_1	58:63	Mutation rewiring degron network	0.0833
p.G73V	TCGA-38-4629	LUAD	TCGA	VEPFPE	LIG_APCC_ABBA_1	58:63	Mutation rewiring degron network	0.0556
p.G73V	DO23771	LUAD	ICGC	VEPFPE	LIG_APCC_ABBA_1	58:63	Mutation rewiring degron network	0.0556
p.G54D	TCGA-B5-A3FA	UCEC	TCGA	VEPFPE	LIG_APCC_ABBA_1	58:63	Mutation rewiring degron network	0.2222
p.G54D	DO52402	UCEC	ICGC	VEPFPE	LIG_APCC_ABBA_1	58:63	Mutation rewiring degron network	0.2222
p.E59K	TCGA-BG-A0M4	UCEC	TCGA	VEPFPE	LIG_APCC_ABBA_1	58:63	Mutation altering degron motif	0.591
p.E59K	DO41686	UCEC	ICGC	VEPFPE	LIG_APCC_ABBA_1	58:63	Mutation altering degron motif	0.591
p.P62Q	TCGA-FS-A1ZK	SKCM	TCGA	VEPFPE	LIG_APCC_ABBA_1	58:63	Mutation altering degron motif	0.5924
p.P62Q	DO37474	SKCM	ICGC	VEPFPE	LIG_APCC_ABBA_1	58:63	Mutation altering degron motif	0.5924
p.F61L	TCGA-GN-A26C	SKCM	TCGA	VEPFPE	LIG_APCC_ABBA_1	58:63	Mutation altering degron motif	0.6981
p.F61L	DO37782	SKCM	ICGC	VEPFPE	LIG_APCC_ABBA_1	58:63	Mutation altering degron motif	0.6981
p.H51Y	DO218173	BRCA	ICGC	VEPFPE	LIG_APCC_ABBA_1	58:63	Mutation rewiring degron network	0.1389
p.N53K	DO223004	ESCA	ICGC	VEPFPE	LIG_APCC_ABBA_1	58:63	Mutation rewiring degron network	0.1944
p.A68T	DO233259	GACA	ICGC	VEPFPE	LIG_APCC_ABBA_1	58:63	Mutation rewiring degron network	0.1944
p.V52F	DO229041	LICA	ICGC	VEPFPE	LIG_APCC_ABBA_1	58:63	Mutation rewiring degron network	0.1667
p.E63A	SIDM00680	Colorectal Carcinoma	GDSC	VEPFPE	LIG_APCC_ABBA_1	58:63	Mutation altering degron motif	0.7701
p.E63A	ACH-000957	Colon/Colorectal Cancer	CCLE	VEPFPE	LIG_APCC_ABBA_1	58:63	Mutation altering degron motif	0.7701
p.E63A	LS-180	large intestine	COSMIC	VEPFPE	LIG_APCC_ABBA_1	58:63	Mutation altering degron motif	0.7701
p.R56G	SIDM00591	Oral Cavity Carcinoma	GDSC	VEPFPE	LIG_APCC_ABBA_1	58:63	Mutation rewiring degron network	0.2778
p.R56G	ACH-002045	Head and Neck Cancer	CCLE	VEPFPE	LIG_APCC_ABBA_1	58:63	Mutation rewiring degron network	0.2778
p.R56G	HO-1-u-1	upper aerodigestive tract	COSMIC	VEPFPE	LIG_APCC_ABBA_1	58:63	Mutation rewiring degron network	0.2778
p.V55M	MZ7-mel	skin	COSMIC	VEPFPE	LIG_APCC_ABBA_1	58:63	Mutation rewiring degron network	0.25
p.A73T	GP5d	large intestine	COSMIC	VEPFPE	LIG_APCC_ABBA_1	58:63	Mutation rewiring degron network	0.0556
p.G54R	NALM-6	haematopoietic and lymphoid tissue	COSMIC	VEPFPE	LIG_APCC_ABBA_1	58:63	Mutation rewiring degron network	0.2222
p.P59S	HCT-15	large intestine	COSMIC	VEPFPE	LIG_APCC_ABBA_1	58:63	Mutation altering degron motif	0.6752
p.R54Q	BC-3	haematopoietic and lymphoid tissue	COSMIC	VEPFPE	LIG_APCC_ABBA_1	58:63	Mutation rewiring degron network	0.2222
p.A50T	GP5d	large intestine	COSMIC	VEPFPE	LIG_APCC_ABBA_1	58:63	Mutation rewiring degron network	0.1111

Kaplan plot for MSRA in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MSRA

UniProt ID: Q9UJ68

Entrez ID: 4482

Protein name: Mitochondrial peptide methionine sulfoxide reductase (EC 1.8.4.11) (Peptide-methionine (S)-S-oxide reductase) (Peptide Met(O) reductase) (Protein-methionine-S-oxide reductase) (PMSR)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MSRA in