DegronMD

Uniprot ID: Q9UJ68

Source protein: Mitochondrial peptide methionine sulfoxide reductase

Source gene: MSRA

Class: LIG_APCC_ABBA_1

Location: 58:63

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8323

ASA_SCORE: 85.15

COIL: 0.9393

CONS_SCORE: 0.3414

DSS_SCORE: 0.3998

HELIX: 0.0072

FCONS_SCORE: 0.7189

RIG_SCORE: 0.7657

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R56I	TCGA-06-5416	GBM	TCGA	VEPFPE	LIG_APCC_ABBA_1	0.2778
p.R56I	DO10880	GBM	ICGC	VEPFPE	LIG_APCC_ABBA_1	0.2778
p.M72I	TCGA-17-Z018	LUAD	TCGA	VEPFPE	LIG_APCC_ABBA_1	0.0833
p.G73V	TCGA-38-4629	LUAD	TCGA	VEPFPE	LIG_APCC_ABBA_1	0.0556
p.G73V	DO23771	LUAD	ICGC	VEPFPE	LIG_APCC_ABBA_1	0.0556
p.G54D	TCGA-B5-A3FA	UCEC	TCGA	VEPFPE	LIG_APCC_ABBA_1	0.2222
p.G54D	DO52402	UCEC	ICGC	VEPFPE	LIG_APCC_ABBA_1	0.2222
p.E59K	TCGA-BG-A0M4	UCEC	TCGA	VEPFPE	LIG_APCC_ABBA_1	0.591
p.E59K	DO41686	UCEC	ICGC	VEPFPE	LIG_APCC_ABBA_1	0.591
p.P62Q	TCGA-FS-A1ZK	SKCM	TCGA	VEPFPE	LIG_APCC_ABBA_1	0.5924
p.P62Q	DO37474	SKCM	ICGC	VEPFPE	LIG_APCC_ABBA_1	0.5924
p.F61L	TCGA-GN-A26C	SKCM	TCGA	VEPFPE	LIG_APCC_ABBA_1	0.6981
p.F61L	DO37782	SKCM	ICGC	VEPFPE	LIG_APCC_ABBA_1	0.6981
p.H51Y	DO218173	BRCA	ICGC	VEPFPE	LIG_APCC_ABBA_1	0.1389
p.N53K	DO223004	ESCA	ICGC	VEPFPE	LIG_APCC_ABBA_1	0.1944
p.A68T	DO233259	GACA	ICGC	VEPFPE	LIG_APCC_ABBA_1	0.1944
p.V52F	DO229041	LICA	ICGC	VEPFPE	LIG_APCC_ABBA_1	0.1667
p.E63A	SIDM00680	Colorectal Carcinoma	GDSC	VEPFPE	LIG_APCC_ABBA_1	0.7701
p.E63A	ACH-000957	Colon/Colorectal Cancer	CCLE	VEPFPE	LIG_APCC_ABBA_1	0.7701
p.E63A	LS-180	large_intestine	COSMIC	VEPFPE	LIG_APCC_ABBA_1	0.7701
p.R56G	SIDM00591	Oral Cavity Carcinoma	GDSC	VEPFPE	LIG_APCC_ABBA_1	0.2778
p.R56G	ACH-002045	Head and Neck Cancer	CCLE	VEPFPE	LIG_APCC_ABBA_1	0.2778
p.R56G	HO-1-u-1	upper_aerodigestive_tract	COSMIC	VEPFPE	LIG_APCC_ABBA_1	0.2778
p.V55M	MZ7-mel	skin	COSMIC	VEPFPE	LIG_APCC_ABBA_1	0.25
p.A73T	GP5d	large_intestine	COSMIC	VEPFPE	LIG_APCC_ABBA_1	0.0556
p.G54R	NALM-6	haematopoietic_and_lymphoid_tissue	COSMIC	VEPFPE	LIG_APCC_ABBA_1	0.2222
p.P59S	HCT-15	large_intestine	COSMIC	VEPFPE	LIG_APCC_ABBA_1	0.6752
p.R54Q	BC-3	haematopoietic_and_lymphoid_tissue	COSMIC	VEPFPE	LIG_APCC_ABBA_1	0.2222
p.A50T	GP5d	large_intestine	COSMIC	VEPFPE	LIG_APCC_ABBA_1	0.1111

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VEPFPE

Degron related mutations and impact score

Drug responses associated with MSRA mutations

All proteins holding degron of VEPFPE

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UJ68	Mitochondrial peptide methionine sulfoxide reductase	LIG_APCC_ABBA_1	58:63	VEPFPE	APC,CDC20,FZR1	0.8323	More...