FUNCTION: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle...
FUNCTION: Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for efficient chromosome alignment and cytokinesis. The BCR(KLHL21) E3 ubiquitin ligase complex regulates localization of the chromosomal passenger complex (CPC) from chromosomes to the spindle midzone in anaphase and mediates the ubiquitination of AURKB. Ubiquitination of AURKB by BCR(KLHL21) E3 ubiquitin ligase complex may not lead to its degradation by the proteasome. {ECO:0000269|PubMed:14528312, ECO:0000269|PubMed:19995937}.
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GO - Biological processes (BP):
cell cycle [GO:0007049]; cell division [GO:0051301]; chromosome passenger complex localization to spindle midzone [GO:0035853]; protein ubiquitination [GO:0016567]; regulation of cytokinesis [GO:0032465]...
cell cycle [GO:0007049]; cell division [GO:0051301]; chromosome passenger complex localization to spindle midzone [GO:0035853]; protein ubiquitination [GO:0016567]; regulation of cytokinesis [GO:0032465]
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GO - Molecular function (MF):
cullin family protein binding [GO:0097602]...
cullin family protein binding [GO:0097602]
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GO - Cellular component (CC):
Cul3-RING ubiquitin ligase complex [GO:0031463]; cytosol [GO:0005829]; polar microtubule [GO:0005827]...
Cul3-RING ubiquitin ligase complex [GO:0031463]; cytosol [GO:0005829]; polar microtubule [GO:0005827]
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