DegronMD - Q9UK05(GDF2)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.K266R	TCGA-60-2722	LUSC	TCGA	TRLELREMI	DEG_APCC_DBOX_1	268:276	Mutation rewiring degron network	0.2778
p.K266R	DO26798	LUSC	ICGC	TRLELREMI	DEG_APCC_DBOX_1	268:276	Mutation rewiring degron network	0.2778
p.E281G	TCGA-98-A53B	LUSC	TCGA	TRLELREMI	DEG_APCC_DBOX_1	268:276	Mutation rewiring degron network	0.1944
p.E281G	DO52023	LUSC	ICGC	TRLELREMI	DEG_APCC_DBOX_1	268:276	Mutation rewiring degron network	0.1944
p.K266N	TCGA-AJ-A3EK	UCEC	TCGA	TRLELREMI	DEG_APCC_DBOX_1	268:276	Mutation rewiring degron network	0.2778
p.K266N	DO41584	UCEC	ICGC	TRLELREMI	DEG_APCC_DBOX_1	268:276	Mutation rewiring degron network	0.2778
p.H261R	TCGA-BG-A222	UCEC	TCGA	TRLELREMI	DEG_APCC_DBOX_1	268:276	Mutation rewiring degron network	0.1389
p.H261R	DO42977	UCEC	ICGC	TRLELREMI	DEG_APCC_DBOX_1	268:276	Mutation rewiring degron network	0.1389
p.V283M	TCGA-G4-6586	COAD	TCGA	TRLELREMI	DEG_APCC_DBOX_1	268:276	Mutation rewiring degron network	0.1389
p.V283M	TCGA-XF-A9T5	BLCA	TCGA	TRLELREMI	DEG_APCC_DBOX_1	268:276	Mutation rewiring degron network	0.1389
p.V283M	DO51925	BLCA	ICGC	TRLELREMI	DEG_APCC_DBOX_1	268:276	Mutation rewiring degron network	0.1389
p.V283M	DO9698	COAD	ICGC	TRLELREMI	DEG_APCC_DBOX_1	268:276	Mutation rewiring degron network	0.1389
p.E271K	DO48286	ESCA	ICGC	TRLELREMI	DEG_APCC_DBOX_1	268:276	Mutation altering degron motif	0.591
p.L270M	DO228297	LICA	ICGC	TRLELREMI	DEG_APCC_DBOX_1	268:276	Mutation altering degron motif	0.5999
p.G264V	DO231043	LUSC	ICGC	TRLELREMI	DEG_APCC_DBOX_1	268:276	Mutation rewiring degron network	0.2222
p.G264E	DO222708	MELA	ICGC	TRLELREMI	DEG_APCC_DBOX_1	268:276	Mutation rewiring degron network	0.2222
p.T268I	SIDM00153	T-Lymphoblastic Leukemia	GDSC	TRLELREMI	DEG_APCC_DBOX_1	268:276	Mutation altering degron motif	0.5966
p.T268I	ACH-000964	Leukemia	CCLE	TRLELREMI	DEG_APCC_DBOX_1	268:276	Mutation altering degron motif	0.5966

Kaplan plot for GDF2 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

GDF2

UniProt ID: Q9UK05

Entrez ID: 2658

Protein name: Growth/differentiation factor 2 (GDF-2) (Bone morphogenetic protein 9) (BMP-9)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for GDF2 in