DegronMD

Uniprot ID: Q9UK05

Source protein: Growth/differentiation factor 2

Source gene: GDF2

Class: DEG_APCC_DBOX_1

Location: 268:276

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9352

ASA_SCORE: 85.1667

COIL: 0.208

CONS_SCORE: 0.4857

DSS_SCORE: 0.5663

HELIX: 0.7802

FCONS_SCORE: 1.0098

RIG_SCORE: 0.7914

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.K266R	TCGA-60-2722	LUSC	TCGA	TRLELREMI	DEG_APCC_DBOX_1	0.2778
p.K266R	DO26798	LUSC	ICGC	TRLELREMI	DEG_APCC_DBOX_1	0.2778
p.E281G	TCGA-98-A53B	LUSC	TCGA	TRLELREMI	DEG_APCC_DBOX_1	0.1944
p.E281G	DO52023	LUSC	ICGC	TRLELREMI	DEG_APCC_DBOX_1	0.1944
p.K266N	TCGA-AJ-A3EK	UCEC	TCGA	TRLELREMI	DEG_APCC_DBOX_1	0.2778
p.K266N	DO41584	UCEC	ICGC	TRLELREMI	DEG_APCC_DBOX_1	0.2778
p.H261R	TCGA-BG-A222	UCEC	TCGA	TRLELREMI	DEG_APCC_DBOX_1	0.1389
p.H261R	DO42977	UCEC	ICGC	TRLELREMI	DEG_APCC_DBOX_1	0.1389
p.V283M	TCGA-G4-6586	COAD	TCGA	TRLELREMI	DEG_APCC_DBOX_1	0.1389
p.V283M	TCGA-XF-A9T5	BLCA	TCGA	TRLELREMI	DEG_APCC_DBOX_1	0.1389
p.V283M	DO51925	BLCA	ICGC	TRLELREMI	DEG_APCC_DBOX_1	0.1389
p.V283M	DO9698	COAD	ICGC	TRLELREMI	DEG_APCC_DBOX_1	0.1389
p.E271K	DO48286	ESCA	ICGC	TRLELREMI	DEG_APCC_DBOX_1	0.591
p.L270M	DO228297	LICA	ICGC	TRLELREMI	DEG_APCC_DBOX_1	0.5999
p.G264V	DO231043	LUSC	ICGC	TRLELREMI	DEG_APCC_DBOX_1	0.2222
p.G264E	DO222708	MELA	ICGC	TRLELREMI	DEG_APCC_DBOX_1	0.2222
p.T268I	SIDM00153	T-Lymphoblastic Leukemia	GDSC	TRLELREMI	DEG_APCC_DBOX_1	0.5966
p.T268I	ACH-000964	Leukemia	CCLE	TRLELREMI	DEG_APCC_DBOX_1	0.5966

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UK05	Growth/differentiation factor 2	DEG_APCC_DBOX_1	268:276	TRLELREMI	APC,CDC20,FZR1	0.9352	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons