DegronMD - Q9UK41(VPS28)

VPS28

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P14H	TCGA-A4-7734	KIRP	TCGA	KPELYEE	LIG_APCC_ABBAyCdc20_2	17:23	Mutation rewiring degron network	0.25
p.P14H	DO20893	KIRP	ICGC	KPELYEE	LIG_APCC_ABBAyCdc20_2	17:23	Mutation rewiring degron network	0.25
p.G15R	TCGA-AD-6895	COAD	TCGA	KPELYEE	LIG_APCC_ABBAyCdc20_2	17:23	Mutation rewiring degron network	0.2778
p.G15R	DO8938	COAD	ICGC	KPELYEE	LIG_APCC_ABBAyCdc20_2	17:23	Mutation rewiring degron network	0.2778
p.P18L	TCGA-XK-AAIW	PRAD	TCGA	KPELYEE	LIG_APCC_ABBAyCdc20_2	17:23	Mutation altering degron motif	0.6471
p.P18L	DO51407	PRAD	ICGC	KPELYEE	LIG_APCC_ABBAyCdc20_2	17:23	Mutation altering degron motif	0.6471
p.E32D	DO225346	BRCA	ICGC	KPELYEE	LIG_APCC_ABBAyCdc20_2	17:23	Mutation rewiring degron network	0.0833
p.E32Q	DO233146	GACA	ICGC	KPELYEE	LIG_APCC_ABBAyCdc20_2	17:23	Mutation rewiring degron network	0.0833
p.N29K	DO229015	LICA	ICGC	KPELYEE	LIG_APCC_ABBAyCdc20_2	17:23	Mutation rewiring degron network	0.1667
p.N29K	DO229041	LICA	ICGC	KPELYEE	LIG_APCC_ABBAyCdc20_2	17:23	Mutation rewiring degron network	0.1667
p.E32K	DO229234	THCA	ICGC	KPELYEE	LIG_APCC_ABBAyCdc20_2	17:23	Mutation rewiring degron network	0.0833
p.G12R	SIDM01024	Esophageal Squamous Cell Carcinoma	GDSC	KPELYEE	LIG_APCC_ABBAyCdc20_2	17:23	Mutation rewiring degron network	0.1944
p.G12R	ACH-000784	Esophageal Cancer	CCLE	KPELYEE	LIG_APCC_ABBAyCdc20_2	17:23	Mutation rewiring degron network	0.1944
p.G12R	KYSE-70	oesophagus	COSMIC	KPELYEE	LIG_APCC_ABBAyCdc20_2	17:23	Mutation rewiring degron network	0.1944

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*NOTE: the Kaplan plots were collected from OncoLnc