DegronMD

Uniprot ID: Q9UK41

Source protein: Vacuolar protein sorting-associated protein 28 homolog

Source gene: VPS28

Class: LIG_APCC_ABBAyCdc20_2

Location: 17:23

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6008

ASA_SCORE: 105.0571

COIL: 0.7494

CONS_SCORE: 0.5117

DSS_SCORE: 0.3442

HELIX: 0.1177

FCONS_SCORE: 1.1372

RIG_SCORE: 0.7918

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P18L	TCGA-XK-AAIW	PRAD	TCGA	KPELYEE	LIG_APCC_ABBAyCdc20_2	0.6471
p.P18L	DO51407	PRAD	ICGC	KPELYEE	LIG_APCC_ABBAyCdc20_2	0.6471
p.G15R	TCGA-AD-6895	COAD	TCGA	KPELYEE	LIG_APCC_ABBAyCdc20_2	0.2778
p.G15R	DO8938	COAD	ICGC	KPELYEE	LIG_APCC_ABBAyCdc20_2	0.2778
p.P14H	TCGA-A4-7734	KIRP	TCGA	KPELYEE	LIG_APCC_ABBAyCdc20_2	0.25
p.P14H	DO20893	KIRP	ICGC	KPELYEE	LIG_APCC_ABBAyCdc20_2	0.25
p.G12R	SIDM01024	Esophageal Squamous Cell Carcinoma	GDSC	KPELYEE	LIG_APCC_ABBAyCdc20_2	0.1944
p.G12R	ACH-000784	Esophageal Cancer	CCLE	KPELYEE	LIG_APCC_ABBAyCdc20_2	0.1944
p.G12R	KYSE-70	oesophagus	COSMIC	KPELYEE	LIG_APCC_ABBAyCdc20_2	0.1944
p.N29K	DO229015	LICA	ICGC	KPELYEE	LIG_APCC_ABBAyCdc20_2	0.1667
p.N29K	DO229041	LICA	ICGC	KPELYEE	LIG_APCC_ABBAyCdc20_2	0.1667
p.E32D	DO225346	BRCA	ICGC	KPELYEE	LIG_APCC_ABBAyCdc20_2	0.0833
p.E32Q	DO233146	GACA	ICGC	KPELYEE	LIG_APCC_ABBAyCdc20_2	0.0833
p.E32K	DO229234	THCA	ICGC	KPELYEE	LIG_APCC_ABBAyCdc20_2	0.0833

Showing 1 to 14 of 14 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UK41	Vacuolar protein sorting-associated protein 28 homolog	LIG_APCC_ABBAyCdc20_2	17:23	KPELYEE	APC,CDC20,FZR1	0.6008	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons