DegronMD: protein-targeted degradation, mutation and drug response to degrons
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BSML
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CGC
Degron:
KPELYEE
Uniprot ID:
Q9UK41
Source protein:
Vacuolar protein sorting-associated protein 28 homolog
Source gene:
VPS28
Class:
LIG_APCC_ABBAyCdc20_2
Location:
17:23
E3 ligase:
APC,CDC20,FZR1
DEGRON score:
0.6008
ASA_SCORE:
105.0571
COIL:
0.7494
CONS_SCORE:
0.5117
DSS_SCORE:
0.3442
HELIX:
0.1177
FCONS_SCORE:
1.1372
RIG_SCORE:
0.7918
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.P14H
TCGA-A4-7734
KIRP
TCGA
KPELYEE
LIG_APCC_ABBAyCdc20_2
0.25
p.P14H
DO20893
KIRP
ICGC
KPELYEE
LIG_APCC_ABBAyCdc20_2
0.25
p.G15R
TCGA-AD-6895
COAD
TCGA
KPELYEE
LIG_APCC_ABBAyCdc20_2
0.2778
p.G15R
DO8938
COAD
ICGC
KPELYEE
LIG_APCC_ABBAyCdc20_2
0.2778
p.P18L
TCGA-XK-AAIW
PRAD
TCGA
KPELYEE
LIG_APCC_ABBAyCdc20_2
0.6471
p.P18L
DO51407
PRAD
ICGC
KPELYEE
LIG_APCC_ABBAyCdc20_2
0.6471
p.E32D
DO225346
BRCA
ICGC
KPELYEE
LIG_APCC_ABBAyCdc20_2
0.0833
p.E32Q
DO233146
GACA
ICGC
KPELYEE
LIG_APCC_ABBAyCdc20_2
0.0833
p.N29K
DO229015
LICA
ICGC
KPELYEE
LIG_APCC_ABBAyCdc20_2
0.1667
p.N29K
DO229041
LICA
ICGC
KPELYEE
LIG_APCC_ABBAyCdc20_2
0.1667
p.E32K
DO229234
THCA
ICGC
KPELYEE
LIG_APCC_ABBAyCdc20_2
0.0833
p.G12R
SIDM01024
Esophageal Squamous Cell Carcinoma
GDSC
KPELYEE
LIG_APCC_ABBAyCdc20_2
0.1944
p.G12R
ACH-000784
Esophageal Cancer
CCLE
KPELYEE
LIG_APCC_ABBAyCdc20_2
0.1944
p.G12R
KYSE-70
oesophagus
COSMIC
KPELYEE
LIG_APCC_ABBAyCdc20_2
0.1944
Drug responses associated with VPS28 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of KPELYEE
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9UK41
Vacuolar protein sorting-associated protein 28 homolog
LIG_APCC_ABBAyCdc20_2
17:23
KPELYEE
APC,CDC20,FZR1
0.6008
More...