DegronMD - Q9UK58(CCNL1)

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GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.L320S	TCGA-AA-A02R	COAD	TCGA	PDGTPALS	DEG_SCF_FBW7_1	322:329	Mutation rewiring degron network	0.2778
p.F334L	TCGA-CD-8529	STAD	TCGA	PDGTPALS	DEG_SCF_FBW7_1	322:329	Mutation rewiring degron network	0.1944
p.F334L	DO47753	STAD	ICGC	PDGTPALS	DEG_SCF_FBW7_1	322:329	Mutation rewiring degron network	0.1944
p.G324E	TCGA-D3-A8GJ	SKCM	TCGA	PDGTPALS	DEG_SCF_FBW7_1	322:329	Mutation altering degron motif	0.6087
p.G324E	DO50285	SKCM	ICGC	PDGTPALS	DEG_SCF_FBW7_1	322:329	Mutation altering degron motif	0.6087
p.A313D	DO228948	LICA	ICGC	PDGTPALS	DEG_SCF_FBW7_1	322:329	Mutation rewiring degron network	0.0833
p.P322Q	DO228952	LICA	ICGC	PDGTPALS	DEG_SCF_FBW7_1	322:329	Mutation altering degron motif	0.7035
p.P326S	DO220886	MELA	ICGC	PDGTPALS	DEG_SCF_FBW7_1	322:329	Mutation altering degron motif	0.6752
p.L331P	SIDM00142	Endometrial Carcinoma	GDSC	PDGTPALS	DEG_SCF_FBW7_1	322:329	Mutation rewiring degron network	0.2778
p.L331P	ACH-000864	Endometrial/Uterine Cancer	CCLE	PDGTPALS	DEG_SCF_FBW7_1	322:329	Mutation rewiring degron network	0.2778
p.L331P	COLO-684	endometrium	COSMIC	PDGTPALS	DEG_SCF_FBW7_1	322:329	Mutation rewiring degron network	0.2778
p.K339R	SIDM00391	Plasma Cell Myeloma	GDSC	PDGTPALS	DEG_SCF_FBW7_1	322:329	Mutation substituting flanking lysine	0.1667
p.K339R	ACH-000363	Myeloma	CCLE	PDGTPALS	DEG_SCF_FBW7_1	322:329	Mutation substituting flanking lysine	0.1667
p.K339R	SK-MM-2	haematopoietic and lymphoid tissue	COSMIC	PDGTPALS	DEG_SCF_FBW7_1	322:329	Mutation substituting flanking lysine	0.1667

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons