DegronMD

Uniprot ID: Q9UK58

Source protein: Cyclin-L1

Source gene: CCNL1

Class: DEG_SCF_FBW7_1

Location: 322:329

E3 ligase: FBXW7

DEGRON score: 0.9965

ASA_SCORE: 77.775

COIL: 0.8918

CONS_SCORE: 0.233

DSS_SCORE: 0.5458

HELIX: 0.0894

FCONS_SCORE: 0.9808

RIG_SCORE: 0.6526

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L320S	TCGA-AA-A02R	COAD	TCGA	PDGTPALS	DEG_SCF_FBW7_1	0.2778
p.F334L	TCGA-CD-8529	STAD	TCGA	PDGTPALS	DEG_SCF_FBW7_1	0.1944
p.F334L	DO47753	STAD	ICGC	PDGTPALS	DEG_SCF_FBW7_1	0.1944
p.G324E	TCGA-D3-A8GJ	SKCM	TCGA	PDGTPALS	DEG_SCF_FBW7_1	0.6087
p.G324E	DO50285	SKCM	ICGC	PDGTPALS	DEG_SCF_FBW7_1	0.6087
p.A313D	DO228948	LICA	ICGC	PDGTPALS	DEG_SCF_FBW7_1	0.0833
p.P322Q	DO228952	LICA	ICGC	PDGTPALS	DEG_SCF_FBW7_1	0.7035
p.P326S	DO220886	MELA	ICGC	PDGTPALS	DEG_SCF_FBW7_1	0.6752
p.L331P	SIDM00142	Endometrial Carcinoma	GDSC	PDGTPALS	DEG_SCF_FBW7_1	0.2778
p.L331P	ACH-000864	Endometrial/Uterine Cancer	CCLE	PDGTPALS	DEG_SCF_FBW7_1	0.2778
p.L331P	COLO-684	endometrium	COSMIC	PDGTPALS	DEG_SCF_FBW7_1	0.2778
p.K339R	SIDM00391	Plasma Cell Myeloma	GDSC	PDGTPALS	DEG_SCF_FBW7_1	0.1667
p.K339R	ACH-000363	Myeloma	CCLE	PDGTPALS	DEG_SCF_FBW7_1	0.1667
p.K339R	SK-MM-2	haematopoietic_and_lymphoid_tissue	COSMIC	PDGTPALS	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UK58	Cyclin-L1	DEG_SCF_FBW7_1	322:329	PDGTPALS	FBXW7	0.9965	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons