DegronMD - Q9UKF7(PITPNC1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.V268I	TCGA-05-4426	LUAD	TCGA	PSTPLST	DEG_SCF_FBW7_1	276:282	Mutation rewiring degron network	0.1111
p.V268I	TCGA-CH-5752	PRAD	TCGA	PSTPLST	DEG_SCF_FBW7_1	276:282	Mutation rewiring degron network	0.1111
p.V268I	TCGA-EO-A22U	UCEC	TCGA	PSTPLST	DEG_SCF_FBW7_1	276:282	Mutation rewiring degron network	0.1111
p.V268I	TCGA-IB-AAUP	PAAD	TCGA	PSTPLST	DEG_SCF_FBW7_1	276:282	Mutation rewiring degron network	0.1111
p.V268I	TCGA-N9-A4Q3	UCS	TCGA	PSTPLST	DEG_SCF_FBW7_1	276:282	Mutation rewiring degron network	0.1111
p.V268I	DO234233	ESAD	ICGC	PSTPLST	DEG_SCF_FBW7_1	276:282	Mutation rewiring degron network	0.1111
p.V268I	DO26300	LUAD	ICGC	PSTPLST	DEG_SCF_FBW7_1	276:282	Mutation rewiring degron network	0.1111
p.V268I	DO51703	PAAD	ICGC	PSTPLST	DEG_SCF_FBW7_1	276:282	Mutation rewiring degron network	0.1111
p.V268I	DO36334	PRAD	ICGC	PSTPLST	DEG_SCF_FBW7_1	276:282	Mutation rewiring degron network	0.1111
p.V268I	DO43755	UCEC	ICGC	PSTPLST	DEG_SCF_FBW7_1	276:282	Mutation rewiring degron network	0.1111
p.V268I	SIDM00837	Colorectal Carcinoma	GDSC	PSTPLST	DEG_SCF_FBW7_1	276:282	Mutation rewiring degron network	0.1111
p.V268I	ACH-000958	Colon/Colorectal Cancer	CCLE	PSTPLST	DEG_SCF_FBW7_1	276:282	Mutation rewiring degron network	0.1111
p.V268I	SW48	large intestine	COSMIC	PSTPLST	DEG_SCF_FBW7_1	276:282	Mutation rewiring degron network	0.1111
p.S277Y	TCGA-24-1426	OV	TCGA	PSTPLST	DEG_SCF_FBW7_1	276:282	Mutation altering degron motif	0.712
p.S277Y	DO30010	OV	ICGC	PSTPLST	DEG_SCF_FBW7_1	276:282	Mutation altering degron motif	0.712
p.T278S	TCGA-44-6777	LUAD	TCGA	PSTPLST	DEG_SCF_FBW7_1	276:282	Mutation altering degron motif	0.8227
p.T278S	DO23645	LUAD	ICGC	PSTPLST	DEG_SCF_FBW7_1	276:282	Mutation altering degron motif	0.8227
p.R269C	TCGA-AZ-4315	COAD	TCGA	PSTPLST	DEG_SCF_FBW7_1	276:282	Mutation rewiring degron network	0.1389
p.R269C	DO8842	COAD	ICGC	PSTPLST	DEG_SCF_FBW7_1	276:282	Mutation rewiring degron network	0.1389
p.R269C	SIDM00217	Colorectal Carcinoma	GDSC	PSTPLST	DEG_SCF_FBW7_1	276:282	Mutation rewiring degron network	0.1389
p.R269C	SNU-1040	large intestine	COSMIC	PSTPLST	DEG_SCF_FBW7_1	276:282	Mutation rewiring degron network	0.1389
p.V290I	TCGA-E9-A1N3	BRCA	TCGA	PSTPLST	DEG_SCF_FBW7_1	276:282	Mutation rewiring degron network	0.1111
p.V290I	DO3251	BRCA	ICGC	PSTPLST	DEG_SCF_FBW7_1	276:282	Mutation rewiring degron network	0.1111
p.A284T	DO233958	BPLL	ICGC	PSTPLST	DEG_SCF_FBW7_1	276:282	Mutation rewiring degron network	0.2778
p.A271V	DO233693	GACA	ICGC	PSTPLST	DEG_SCF_FBW7_1	276:282	Mutation rewiring degron network	0.1944
p.S270C	DO228203	LICA	ICGC	PSTPLST	DEG_SCF_FBW7_1	276:282	Mutation blocking phosphorylation signal	0.6111
p.L280F	DO44828	LICA	ICGC	PSTPLST	DEG_SCF_FBW7_1	276:282	Mutation altering degron motif	0.587
p.P279T	DO50727	ORCA	ICGC	PSTPLST	DEG_SCF_FBW7_1	276:282	Mutation altering degron motif	0.7031
p.P279T	DO35442	PACA	ICGC	PSTPLST	DEG_SCF_FBW7_1	276:282	Mutation altering degron motif	0.7031
p.R269H	SIDM00403	T-Lymphoblastic Leukemia	GDSC	PSTPLST	DEG_SCF_FBW7_1	276:282	Mutation rewiring degron network	0.1389
p.R269H	SIDM00732	Glioblastoma	GDSC	PSTPLST	DEG_SCF_FBW7_1	276:282	Mutation rewiring degron network	0.1389
p.K292R	SIDM00562	Breast Carcinoma	GDSC	PSTPLST	DEG_SCF_FBW7_1	276:282	Mutation substituting flanking lysine	0.1667
p.K292R	SIDM00250	Esophageal Squamous Cell Carcinoma	GDSC	PSTPLST	DEG_SCF_FBW7_1	276:282	Mutation substituting flanking lysine	0.1667
p.K292R	SIDM01019	Acute Myeloid Leukemia	GDSC	PSTPLST	DEG_SCF_FBW7_1	276:282	Mutation substituting flanking lysine	0.1667
p.K292R	ACH-000917	Esophageal Cancer	CCLE	PSTPLST	DEG_SCF_FBW7_1	276:282	Mutation substituting flanking lysine	0.1667
p.K292R	ACH-002163	Breast Cancer	CCLE	PSTPLST	DEG_SCF_FBW7_1	276:282	Mutation substituting flanking lysine	0.1667
p.K292R	ACH-002258	Leukemia	CCLE	PSTPLST	DEG_SCF_FBW7_1	276:282	Mutation substituting flanking lysine	0.1667
p.K292R	KMOE-2	haematopoietic and lymphoid tissue	COSMIC	PSTPLST	DEG_SCF_FBW7_1	276:282	Mutation substituting flanking lysine	0.1667
p.K292R	TE-4	oesophagus	COSMIC	PSTPLST	DEG_SCF_FBW7_1	276:282	Mutation substituting flanking lysine	0.1667
p.K292R	MRK-nu-1	breast	COSMIC	PSTPLST	DEG_SCF_FBW7_1	276:282	Mutation substituting flanking lysine	0.1667
p.P276A	ACH-000975	Lung Cancer	CCLE	PSTPLST	DEG_SCF_FBW7_1	276:282	Mutation altering degron motif	0.7503

Kaplan plot for PITPNC1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PITPNC1

UniProt ID: Q9UKF7

Entrez ID: 26207

Protein name: Cytoplasmic phosphatidylinositol transfer protein 1 (Mammalian rdgB homolog beta) (M-rdgB beta) (MrdgBbeta) (Retinal degeneration B homolog beta) (RdgBbeta)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PITPNC1 in