DegronMD

Uniprot ID: Q9UKF7

Source protein: Cytoplasmic phosphatidylinositol transfer protein 1

Source gene: PITPNC1

Class: DEG_SCF_FBW7_1

Location: 276:282

E3 ligase: FBXW7

DEGRON score: 0.9968

ASA_SCORE: 81.2286

COIL: 0.9297

CONS_SCORE: 0.6614

DSS_SCORE: 0.5931

HELIX: 0.0436

FCONS_SCORE: 0.9978

RIG_SCORE: 0.5655

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V268I	TCGA-05-4426	LUAD	TCGA	PSTPLST	DEG_SCF_FBW7_1	0.1111
p.V268I	TCGA-CH-5752	PRAD	TCGA	PSTPLST	DEG_SCF_FBW7_1	0.1111
p.V268I	TCGA-EO-A22U	UCEC	TCGA	PSTPLST	DEG_SCF_FBW7_1	0.1111
p.V268I	TCGA-IB-AAUP	PAAD	TCGA	PSTPLST	DEG_SCF_FBW7_1	0.1111
p.V268I	TCGA-N9-A4Q3	UCS	TCGA	PSTPLST	DEG_SCF_FBW7_1	0.1111
p.V268I	DO234233	ESAD	ICGC	PSTPLST	DEG_SCF_FBW7_1	0.1111
p.V268I	DO26300	LUAD	ICGC	PSTPLST	DEG_SCF_FBW7_1	0.1111
p.V268I	DO51703	PAAD	ICGC	PSTPLST	DEG_SCF_FBW7_1	0.1111
p.V268I	DO36334	PRAD	ICGC	PSTPLST	DEG_SCF_FBW7_1	0.1111
p.V268I	DO43755	UCEC	ICGC	PSTPLST	DEG_SCF_FBW7_1	0.1111
p.V268I	SIDM00837	Colorectal Carcinoma	GDSC	PSTPLST	DEG_SCF_FBW7_1	0.1111
p.V268I	ACH-000958	Colon/Colorectal Cancer	CCLE	PSTPLST	DEG_SCF_FBW7_1	0.1111
p.V268I	SW48	large_intestine	COSMIC	PSTPLST	DEG_SCF_FBW7_1	0.1111
p.S277Y	TCGA-24-1426	OV	TCGA	PSTPLST	DEG_SCF_FBW7_1	0.712
p.S277Y	DO30010	OV	ICGC	PSTPLST	DEG_SCF_FBW7_1	0.712
p.T278S	TCGA-44-6777	LUAD	TCGA	PSTPLST	DEG_SCF_FBW7_1	0.8227
p.T278S	DO23645	LUAD	ICGC	PSTPLST	DEG_SCF_FBW7_1	0.8227
p.R269C	TCGA-AZ-4315	COAD	TCGA	PSTPLST	DEG_SCF_FBW7_1	0.1389
p.R269C	DO8842	COAD	ICGC	PSTPLST	DEG_SCF_FBW7_1	0.1389
p.R269C	SIDM00217	Colorectal Carcinoma	GDSC	PSTPLST	DEG_SCF_FBW7_1	0.1389
p.R269C	SNU-1040	large_intestine	COSMIC	PSTPLST	DEG_SCF_FBW7_1	0.1389
p.V290I	TCGA-E9-A1N3	BRCA	TCGA	PSTPLST	DEG_SCF_FBW7_1	0.1111
p.V290I	DO3251	BRCA	ICGC	PSTPLST	DEG_SCF_FBW7_1	0.1111
p.A284T	DO233958	BPLL	ICGC	PSTPLST	DEG_SCF_FBW7_1	0.2778
p.A271V	DO233693	GACA	ICGC	PSTPLST	DEG_SCF_FBW7_1	0.1944
p.S270C	DO228203	LICA	ICGC	PSTPLST	DEG_SCF_FBW7_1	0.6111
p.L280F	DO44828	LICA	ICGC	PSTPLST	DEG_SCF_FBW7_1	0.587
p.P279T	DO50727	ORCA	ICGC	PSTPLST	DEG_SCF_FBW7_1	0.7031
p.P279T	DO35442	PACA	ICGC	PSTPLST	DEG_SCF_FBW7_1	0.7031
p.R269H	SIDM00403	T-Lymphoblastic Leukemia	GDSC	PSTPLST	DEG_SCF_FBW7_1	0.1389
p.R269H	SIDM00732	Glioblastoma	GDSC	PSTPLST	DEG_SCF_FBW7_1	0.1389
p.K292R	SIDM00562	Breast Carcinoma	GDSC	PSTPLST	DEG_SCF_FBW7_1	0.1667
p.K292R	SIDM00250	Esophageal Squamous Cell Carcinoma	GDSC	PSTPLST	DEG_SCF_FBW7_1	0.1667
p.K292R	SIDM01019	Acute Myeloid Leukemia	GDSC	PSTPLST	DEG_SCF_FBW7_1	0.1667
p.K292R	ACH-000917	Esophageal Cancer	CCLE	PSTPLST	DEG_SCF_FBW7_1	0.1667
p.K292R	ACH-002163	Breast Cancer	CCLE	PSTPLST	DEG_SCF_FBW7_1	0.1667
p.K292R	ACH-002258	Leukemia	CCLE	PSTPLST	DEG_SCF_FBW7_1	0.1667
p.K292R	KMOE-2	haematopoietic_and_lymphoid_tissue	COSMIC	PSTPLST	DEG_SCF_FBW7_1	0.1667
p.K292R	TE-4	oesophagus	COSMIC	PSTPLST	DEG_SCF_FBW7_1	0.1667
p.K292R	MRK-nu-1	breast	COSMIC	PSTPLST	DEG_SCF_FBW7_1	0.1667
p.P276A	ACH-000975	Lung Cancer	CCLE	PSTPLST	DEG_SCF_FBW7_1	0.7503

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PSTPLST

Degron related mutations and impact score

Drug responses associated with PITPNC1 mutations

All proteins holding degron of PSTPLST

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UKF7	Cytoplasmic phosphatidylinositol transfer protein 1	DEG_SCF_FBW7_1	276:282	PSTPLST	FBXW7	0.9968	More...