DegronMD - Q9UKG9(CROT)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Y35S	TCGA-91-6830	LUAD	TCGA	DSLPSLPVPSL	DEG_COP1_1	18:28	Mutation blocking phosphorylation signal	0.5833
p.Y35S	DO25867	LUAD	ICGC	DSLPSLPVPSL	DEG_COP1_1	18:28	Mutation blocking phosphorylation signal	0.5833
p.P21Q	TCGA-AD-5900	COAD	TCGA	DSLPSLPVPSL	DEG_COP1_1	18:28	Mutation altering degron motif	0.5924
p.P21Q	DO8514	COAD	ICGC	DSLPSLPVPSL	DEG_COP1_1	18:28	Mutation altering degron motif	0.5924
p.F14L	TCGA-B5-A0JX	UCEC	TCGA	DSLPSLPVPSL	DEG_COP1_1	18:28	Mutation rewiring degron network	0.2222
p.F14L	DO43322	UCEC	ICGC	DSLPSLPVPSL	DEG_COP1_1	18:28	Mutation rewiring degron network	0.2222
p.F14L	SIDM00282	Colorectal Carcinoma	GDSC	DSLPSLPVPSL	DEG_COP1_1	18:28	Mutation rewiring degron network	0.2222
p.F14L	ACH-000998	Colon/Colorectal Cancer	CCLE	DSLPSLPVPSL	DEG_COP1_1	18:28	Mutation rewiring degron network	0.2222
p.F14L	CW-2	large intestine	COSMIC	DSLPSLPVPSL	DEG_COP1_1	18:28	Mutation rewiring degron network	0.2222
p.K33Q	TCGA-B5-A1MR	UCEC	TCGA	DSLPSLPVPSL	DEG_COP1_1	18:28	Mutation substituting flanking lysine	0.3056
p.K33Q	DO41758	UCEC	ICGC	DSLPSLPVPSL	DEG_COP1_1	18:28	Mutation substituting flanking lysine	0.3056
p.P26S	TCGA-EE-A2MU	SKCM	TCGA	DSLPSLPVPSL	DEG_COP1_1	18:28	Mutation altering degron motif	0.6752
p.P26S	DO37436	SKCM	ICGC	DSLPSLPVPSL	DEG_COP1_1	18:28	Mutation altering degron motif	0.6752
p.E37K	TCGA-FR-A726	SKCM	TCGA	DSLPSLPVPSL	DEG_COP1_1	18:28	Mutation rewiring degron network	0.0833
p.E37K	DO48665	SKCM	ICGC	DSLPSLPVPSL	DEG_COP1_1	18:28	Mutation rewiring degron network	0.0833
p.L32F	DO234345	ESAD	ICGC	DSLPSLPVPSL	DEG_COP1_1	18:28	Mutation rewiring degron network	0.2222
p.P24T	DO233166	GACA	ICGC	DSLPSLPVPSL	DEG_COP1_1	18:28	Mutation altering degron motif	0.5919
p.E29K	DO229446	SKCA	ICGC	DSLPSLPVPSL	DEG_COP1_1	18:28	Mutation rewiring degron network	0.3056
p.V25A	SIDM01247	Burkitt's Lymphoma	GDSC	DSLPSLPVPSL	DEG_COP1_1	18:28	Mutation altering degron motif	0.6936
p.V25A	SIDM01761	Rhabdomyosarcoma	GDSC	DSLPSLPVPSL	DEG_COP1_1	18:28	Mutation altering degron motif	0.6936
p.S8L	ACH-000601	Pancreatic Cancer	CCLE	DSLPSLPVPSL	DEG_COP1_1	18:28	Mutation blocking phosphorylation signal	0.5

Kaplan plot for CROT in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CROT

UniProt ID: Q9UKG9

Entrez ID: 54677

Protein name: Peroxisomal carnitine O-octanoyltransferase (COT) (EC 2.3.1.137)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CROT in