DegronMD

Uniprot ID: Q9UKG9

Source protein: Peroxisomal carnitine O-octanoyltransferase

Source gene: CROT

Class: DEG_COP1_1

Location: 18:28

E3 ligase: COP1

DEGRON score: 0.999

ASA_SCORE: 54.3182

COIL: 0.8155

CONS_SCORE: 0.7659

DSS_SCORE: 0.4439

HELIX: 0.1715

FCONS_SCORE: 1.147

RIG_SCORE: 0.6984

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Y35S	TCGA-91-6830	LUAD	TCGA	DSLPSLPVPSL	DEG_COP1_1	0.5833
p.Y35S	DO25867	LUAD	ICGC	DSLPSLPVPSL	DEG_COP1_1	0.5833
p.P21Q	TCGA-AD-5900	COAD	TCGA	DSLPSLPVPSL	DEG_COP1_1	0.5924
p.P21Q	DO8514	COAD	ICGC	DSLPSLPVPSL	DEG_COP1_1	0.5924
p.F14L	TCGA-B5-A0JX	UCEC	TCGA	DSLPSLPVPSL	DEG_COP1_1	0.2222
p.F14L	DO43322	UCEC	ICGC	DSLPSLPVPSL	DEG_COP1_1	0.2222
p.F14L	SIDM00282	Colorectal Carcinoma	GDSC	DSLPSLPVPSL	DEG_COP1_1	0.2222
p.F14L	ACH-000998	Colon/Colorectal Cancer	CCLE	DSLPSLPVPSL	DEG_COP1_1	0.2222
p.F14L	CW-2	large_intestine	COSMIC	DSLPSLPVPSL	DEG_COP1_1	0.2222
p.K33Q	TCGA-B5-A1MR	UCEC	TCGA	DSLPSLPVPSL	DEG_COP1_1	0.3056
p.K33Q	DO41758	UCEC	ICGC	DSLPSLPVPSL	DEG_COP1_1	0.3056
p.P26S	TCGA-EE-A2MU	SKCM	TCGA	DSLPSLPVPSL	DEG_COP1_1	0.6752
p.P26S	DO37436	SKCM	ICGC	DSLPSLPVPSL	DEG_COP1_1	0.6752
p.E37K	TCGA-FR-A726	SKCM	TCGA	DSLPSLPVPSL	DEG_COP1_1	0.0833
p.E37K	DO48665	SKCM	ICGC	DSLPSLPVPSL	DEG_COP1_1	0.0833
p.L32F	DO234345	ESAD	ICGC	DSLPSLPVPSL	DEG_COP1_1	0.2222
p.P24T	DO233166	GACA	ICGC	DSLPSLPVPSL	DEG_COP1_1	0.5919
p.E29K	DO229446	SKCA	ICGC	DSLPSLPVPSL	DEG_COP1_1	0.3056
p.V25A	SIDM01247	Burkitt's Lymphoma	GDSC	DSLPSLPVPSL	DEG_COP1_1	0.6936
p.V25A	SIDM01761	Rhabdomyosarcoma	GDSC	DSLPSLPVPSL	DEG_COP1_1	0.6936
p.S8L	ACH-000601	Pancreatic Cancer	CCLE	DSLPSLPVPSL	DEG_COP1_1	0.5

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UKG9	Peroxisomal carnitine O-octanoyltransferase	DEG_COP1_1	18:28	DSLPSLPVPSL	COP1	0.999	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons