DegronMD - Q9UKQ2(ADAM28)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.A754T	TCGA-BR-4184	STAD	TCGA	PVSTPKDS	DEG_SCF_FBW7_1	764:771	Mutation rewiring degron network	0.0556
p.A754T	TCGA-MX-A5UJ	STAD	TCGA	PVSTPKDS	DEG_SCF_FBW7_1	764:771	Mutation rewiring degron network	0.0556
p.A754T	DO48547	STAD	ICGC	PVSTPKDS	DEG_SCF_FBW7_1	764:771	Mutation rewiring degron network	0.0556
p.A754T	DO38328	STAD	ICGC	PVSTPKDS	DEG_SCF_FBW7_1	764:771	Mutation rewiring degron network	0.0556
p.D762N	TCGA-EE-A3JB	SKCM	TCGA	PVSTPKDS	DEG_SCF_FBW7_1	764:771	Mutation rewiring degron network	0.2778
p.D762N	DO222527	MELA	ICGC	PVSTPKDS	DEG_SCF_FBW7_1	764:771	Mutation rewiring degron network	0.2778
p.D762N	DO229465	SKCA	ICGC	PVSTPKDS	DEG_SCF_FBW7_1	764:771	Mutation rewiring degron network	0.2778
p.D762N	DO51250	SKCM	ICGC	PVSTPKDS	DEG_SCF_FBW7_1	764:771	Mutation rewiring degron network	0.2778
p.P773L	TCGA-W3-AA1V	SKCM	TCGA	PVSTPKDS	DEG_SCF_FBW7_1	764:771	Mutation rewiring degron network	0.2778
p.P773L	DO51276	SKCM	ICGC	PVSTPKDS	DEG_SCF_FBW7_1	764:771	Mutation rewiring degron network	0.2778
p.V765M	DO229010	COCA	ICGC	PVSTPKDS	DEG_SCF_FBW7_1	764:771	Mutation altering degron motif	0.6097
p.V765M	DO229013	COCA	ICGC	PVSTPKDS	DEG_SCF_FBW7_1	764:771	Mutation altering degron motif	0.6097
p.V765M	DO229016	COCA	ICGC	PVSTPKDS	DEG_SCF_FBW7_1	764:771	Mutation altering degron motif	0.6097
p.V765M	DO229003	COCA	ICGC	PVSTPKDS	DEG_SCF_FBW7_1	764:771	Mutation altering degron motif	0.6097
p.V765M	DO229005	COCA	ICGC	PVSTPKDS	DEG_SCF_FBW7_1	764:771	Mutation altering degron motif	0.6097
p.K761N	DO229029	LICA	ICGC	PVSTPKDS	DEG_SCF_FBW7_1	764:771	Mutation substituting flanking lysine	0.3611
p.A754S	DO229041	LICA	ICGC	PVSTPKDS	DEG_SCF_FBW7_1	764:771	Mutation rewiring degron network	0.0556
p.P773S	DO222395	MELA	ICGC	PVSTPKDS	DEG_SCF_FBW7_1	764:771	Mutation rewiring degron network	0.2778
p.T758I	DO222420	MELA	ICGC	PVSTPKDS	DEG_SCF_FBW7_1	764:771	Mutation rewiring degron network	0.1667
p.L755F	SIDM01155	Glioma	GDSC	PVSTPKDS	DEG_SCF_FBW7_1	764:771	Mutation rewiring degron network	0.0833
p.L755F	ACH-000437	Brain Cancer	CCLE	PVSTPKDS	DEG_SCF_FBW7_1	764:771	Mutation rewiring degron network	0.0833
p.L755F	SW1088	central nervous system	COSMIC	PVSTPKDS	DEG_SCF_FBW7_1	764:771	Mutation rewiring degron network	0.0833

Kaplan plot for ADAM28 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ADAM28

UniProt ID: Q9UKQ2

Entrez ID: 10863

Protein name: Disintegrin and metalloproteinase domain-containing protein 28 (ADAM 28) (EC 3.4.24.-) (Epididymal metalloproteinase-like, disintegrin-like, and cysteine-rich protein II) (eMDC II) (Metalloproteinase-like, disintegrin-like, and cysteine-rich protein L) (MDC-L)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ADAM28 in