DegronMD

Uniprot ID: Q9UKQ2

Source protein: Disintegrin and metalloproteinase domain-containing protein 28

Source gene: ADAM28

Class: DEG_SCF_FBW7_1

Location: 764:771

E3 ligase: FBXW7

DEGRON score: 0.8242

ASA_SCORE: 91.325

COIL: 0.9544

CONS_SCORE: 0.2814

DSS_SCORE: 0.7864

HELIX: 0.0198

FCONS_SCORE: 0.9227

RIG_SCORE: 0.6318

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A754T	TCGA-BR-4184	STAD	TCGA	PVSTPKDS	DEG_SCF_FBW7_1	0.0556
p.A754T	TCGA-MX-A5UJ	STAD	TCGA	PVSTPKDS	DEG_SCF_FBW7_1	0.0556
p.A754T	DO48547	STAD	ICGC	PVSTPKDS	DEG_SCF_FBW7_1	0.0556
p.A754T	DO38328	STAD	ICGC	PVSTPKDS	DEG_SCF_FBW7_1	0.0556
p.D762N	TCGA-EE-A3JB	SKCM	TCGA	PVSTPKDS	DEG_SCF_FBW7_1	0.2778
p.D762N	DO222527	MELA	ICGC	PVSTPKDS	DEG_SCF_FBW7_1	0.2778
p.D762N	DO229465	SKCA	ICGC	PVSTPKDS	DEG_SCF_FBW7_1	0.2778
p.D762N	DO51250	SKCM	ICGC	PVSTPKDS	DEG_SCF_FBW7_1	0.2778
p.P773L	TCGA-W3-AA1V	SKCM	TCGA	PVSTPKDS	DEG_SCF_FBW7_1	0.2778
p.P773L	DO51276	SKCM	ICGC	PVSTPKDS	DEG_SCF_FBW7_1	0.2778
p.V765M	DO229010	COCA	ICGC	PVSTPKDS	DEG_SCF_FBW7_1	0.6097
p.V765M	DO229013	COCA	ICGC	PVSTPKDS	DEG_SCF_FBW7_1	0.6097
p.V765M	DO229016	COCA	ICGC	PVSTPKDS	DEG_SCF_FBW7_1	0.6097
p.V765M	DO229003	COCA	ICGC	PVSTPKDS	DEG_SCF_FBW7_1	0.6097
p.V765M	DO229005	COCA	ICGC	PVSTPKDS	DEG_SCF_FBW7_1	0.6097
p.K761N	DO229029	LICA	ICGC	PVSTPKDS	DEG_SCF_FBW7_1	0.3611
p.A754S	DO229041	LICA	ICGC	PVSTPKDS	DEG_SCF_FBW7_1	0.0556
p.P773S	DO222395	MELA	ICGC	PVSTPKDS	DEG_SCF_FBW7_1	0.2778
p.T758I	DO222420	MELA	ICGC	PVSTPKDS	DEG_SCF_FBW7_1	0.1667
p.L755F	SIDM01155	Glioma	GDSC	PVSTPKDS	DEG_SCF_FBW7_1	0.0833
p.L755F	ACH-000437	Brain Cancer	CCLE	PVSTPKDS	DEG_SCF_FBW7_1	0.0833
p.L755F	SW1088	central_nervous_system	COSMIC	PVSTPKDS	DEG_SCF_FBW7_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UKQ2	Disintegrin and metalloproteinase domain-containing protein 28	DEG_SCF_FBW7_1	764:771	PVSTPKDS	FBXW7	0.8242	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons