DegronMD - Q9UKR3(KLK13)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R158L	TCGA-68-7757	LUSC	TCGA	LTPGTT	DEG_SCF_FBW7_1	151:156	Mutation rewiring degron network	0.2778
p.R158L	TCGA-CV-6933	HNSC	TCGA	LTPGTT	DEG_SCF_FBW7_1	151:156	Mutation rewiring degron network	0.2778
p.R158L	DO14164	HNSC	ICGC	LTPGTT	DEG_SCF_FBW7_1	151:156	Mutation rewiring degron network	0.2778
p.R158L	DO26886	LUSC	ICGC	LTPGTT	DEG_SCF_FBW7_1	151:156	Mutation rewiring degron network	0.2778
p.R158L	SIDM00762	Non-Small Cell Lung Carcinoma	GDSC	LTPGTT	DEG_SCF_FBW7_1	151:156	Mutation rewiring degron network	0.2778
p.R158L	ACH-000414	Lung Cancer	CCLE	LTPGTT	DEG_SCF_FBW7_1	151:156	Mutation rewiring degron network	0.2778
p.R158L	NCI-H1944	lung	COSMIC	LTPGTT	DEG_SCF_FBW7_1	151:156	Mutation rewiring degron network	0.2778
p.R150C	TCGA-AP-A0LM	UCEC	TCGA	LTPGTT	DEG_SCF_FBW7_1	151:156	Mutation rewiring degron network	0.3056
p.R150C	DO43306	UCEC	ICGC	LTPGTT	DEG_SCF_FBW7_1	151:156	Mutation rewiring degron network	0.3056
p.G161D	TCGA-AU-6004	COAD	TCGA	LTPGTT	DEG_SCF_FBW7_1	151:156	Mutation rewiring degron network	0.1944
p.G161D	DO7780	COAD	ICGC	LTPGTT	DEG_SCF_FBW7_1	151:156	Mutation rewiring degron network	0.1944
p.C157Y	TCGA-AX-A2HD	UCEC	TCGA	LTPGTT	DEG_SCF_FBW7_1	151:156	Mutation rewiring degron network	0.3056
p.C157Y	DO42608	UCEC	ICGC	LTPGTT	DEG_SCF_FBW7_1	151:156	Mutation rewiring degron network	0.3056
p.N148D	TCGA-B5-A1MX	UCEC	TCGA	LTPGTT	DEG_SCF_FBW7_1	151:156	Mutation rewiring degron network	0.25
p.N148D	DO41999	UCEC	ICGC	LTPGTT	DEG_SCF_FBW7_1	151:156	Mutation rewiring degron network	0.25
p.R158W	TCGA-EY-A215	UCEC	TCGA	LTPGTT	DEG_SCF_FBW7_1	151:156	Mutation rewiring degron network	0.2778
p.R158W	DO42665	UCEC	ICGC	LTPGTT	DEG_SCF_FBW7_1	151:156	Mutation rewiring degron network	0.2778
p.W161C	DO230309	COCA	ICGC	LTPGTT	DEG_SCF_FBW7_1	151:156	Mutation rewiring degron network	0.1944
p.P165Q	DO229027	LICA	ICGC	LTPGTT	DEG_SCF_FBW7_1	151:156	Mutation rewiring degron network	0.0833
p.G143D	DO220854	MELA	ICGC	LTPGTT	DEG_SCF_FBW7_1	151:156	Mutation rewiring degron network	0.1111
p.P165S	DO220876	MELA	ICGC	LTPGTT	DEG_SCF_FBW7_1	151:156	Mutation rewiring degron network	0.0833
p.P153R	DO51474	PACA	ICGC	LTPGTT	DEG_SCF_FBW7_1	151:156	Mutation altering degron motif	0.7512
p.L149V	DO219944	SARC	ICGC	LTPGTT	DEG_SCF_FBW7_1	151:156	Mutation rewiring degron network	0.2778
p.G157D	DO229446	SKCA	ICGC	LTPGTT	DEG_SCF_FBW7_1	151:156	Mutation rewiring degron network	0.3056
p.S160F	DO37823	SKCM	ICGC	LTPGTT	DEG_SCF_FBW7_1	151:156	Mutation rewiring degron network	0.2222
p.V159L	SIDM00337	Melanoma	GDSC	LTPGTT	DEG_SCF_FBW7_1	151:156	Mutation rewiring degron network	0.25
p.V159L	ACH-000450	Skin Cancer	CCLE	LTPGTT	DEG_SCF_FBW7_1	151:156	Mutation rewiring degron network	0.25
p.V159L	MEL-HO	skin	COSMIC	LTPGTT	DEG_SCF_FBW7_1	151:156	Mutation rewiring degron network	0.25
p.P153S	SIDM00217	Colorectal Carcinoma	GDSC	LTPGTT	DEG_SCF_FBW7_1	151:156	Mutation altering degron motif	0.6752
p.P153S	ACH-000999	Colon/Colorectal Cancer	CCLE	LTPGTT	DEG_SCF_FBW7_1	151:156	Mutation altering degron motif	0.6752
p.P153S	SNU-1040	large intestine	COSMIC	LTPGTT	DEG_SCF_FBW7_1	151:156	Mutation altering degron motif	0.6752
p.G161V	ACH-002005	Skin Cancer	CCLE	LTPGTT	DEG_SCF_FBW7_1	151:156	Mutation rewiring degron network	0.1944
p.G147A	AMO-1	haematopoietic and lymphoid tissue	COSMIC	LTPGTT	DEG_SCF_FBW7_1	151:156	Mutation rewiring degron network	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KLK13

UniProt ID: Q9UKR3

Entrez ID: 26085

Protein name: Kallikrein-13 (EC 3.4.21.-) (Kallikrein-like protein 4) (KLK-L4)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KLK13 in