DegronMD

Uniprot ID: Q9UKR3

Source protein: Kallikrein-13

Source gene: KLK13

Class: DEG_SCF_FBW7_1

Location: 151:156

E3 ligase: FBXW7

DEGRON score: 0.9594

ASA_SCORE: 56.4833

COIL: 0.817

CONS_SCORE: 0.5764

DSS_SCORE: 0.3893

HELIX: 0.0047

FCONS_SCORE: 0.9697

RIG_SCORE: 0.717

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R158L	TCGA-68-7757	LUSC	TCGA	LTPGTT	DEG_SCF_FBW7_1	0.2778
p.R158L	TCGA-CV-6933	HNSC	TCGA	LTPGTT	DEG_SCF_FBW7_1	0.2778
p.R158L	DO14164	HNSC	ICGC	LTPGTT	DEG_SCF_FBW7_1	0.2778
p.R158L	DO26886	LUSC	ICGC	LTPGTT	DEG_SCF_FBW7_1	0.2778
p.R158L	SIDM00762	Non-Small Cell Lung Carcinoma	GDSC	LTPGTT	DEG_SCF_FBW7_1	0.2778
p.R158L	ACH-000414	Lung Cancer	CCLE	LTPGTT	DEG_SCF_FBW7_1	0.2778
p.R158L	NCI-H1944	lung	COSMIC	LTPGTT	DEG_SCF_FBW7_1	0.2778
p.R150C	TCGA-AP-A0LM	UCEC	TCGA	LTPGTT	DEG_SCF_FBW7_1	0.3056
p.R150C	DO43306	UCEC	ICGC	LTPGTT	DEG_SCF_FBW7_1	0.3056
p.G161D	TCGA-AU-6004	COAD	TCGA	LTPGTT	DEG_SCF_FBW7_1	0.1944
p.G161D	DO7780	COAD	ICGC	LTPGTT	DEG_SCF_FBW7_1	0.1944
p.C157Y	TCGA-AX-A2HD	UCEC	TCGA	LTPGTT	DEG_SCF_FBW7_1	0.3056
p.C157Y	DO42608	UCEC	ICGC	LTPGTT	DEG_SCF_FBW7_1	0.3056
p.N148D	TCGA-B5-A1MX	UCEC	TCGA	LTPGTT	DEG_SCF_FBW7_1	0.25
p.N148D	DO41999	UCEC	ICGC	LTPGTT	DEG_SCF_FBW7_1	0.25
p.R158W	TCGA-EY-A215	UCEC	TCGA	LTPGTT	DEG_SCF_FBW7_1	0.2778
p.R158W	DO42665	UCEC	ICGC	LTPGTT	DEG_SCF_FBW7_1	0.2778
p.W161C	DO230309	COCA	ICGC	LTPGTT	DEG_SCF_FBW7_1	0.1944
p.P165Q	DO229027	LICA	ICGC	LTPGTT	DEG_SCF_FBW7_1	0.0833
p.G143D	DO220854	MELA	ICGC	LTPGTT	DEG_SCF_FBW7_1	0.1111
p.P165S	DO220876	MELA	ICGC	LTPGTT	DEG_SCF_FBW7_1	0.0833
p.P153R	DO51474	PACA	ICGC	LTPGTT	DEG_SCF_FBW7_1	0.7512
p.L149V	DO219944	SARC	ICGC	LTPGTT	DEG_SCF_FBW7_1	0.2778
p.G157D	DO229446	SKCA	ICGC	LTPGTT	DEG_SCF_FBW7_1	0.3056
p.S160F	DO37823	SKCM	ICGC	LTPGTT	DEG_SCF_FBW7_1	0.2222
p.V159L	SIDM00337	Melanoma	GDSC	LTPGTT	DEG_SCF_FBW7_1	0.25
p.V159L	ACH-000450	Skin Cancer	CCLE	LTPGTT	DEG_SCF_FBW7_1	0.25
p.V159L	MEL-HO	skin	COSMIC	LTPGTT	DEG_SCF_FBW7_1	0.25
p.P153S	SIDM00217	Colorectal Carcinoma	GDSC	LTPGTT	DEG_SCF_FBW7_1	0.6752
p.P153S	ACH-000999	Colon/Colorectal Cancer	CCLE	LTPGTT	DEG_SCF_FBW7_1	0.6752
p.P153S	SNU-1040	large_intestine	COSMIC	LTPGTT	DEG_SCF_FBW7_1	0.6752
p.G161V	ACH-002005	Skin Cancer	CCLE	LTPGTT	DEG_SCF_FBW7_1	0.1944
p.G147A	AMO-1	haematopoietic_and_lymphoid_tissue	COSMIC	LTPGTT	DEG_SCF_FBW7_1	0.2222

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: LTPGTT

Degron related mutations and impact score

Drug responses associated with KLK13 mutations

All proteins holding degron of LTPGTT

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9UKR3	Kallikrein-13	DEG_SCF_FBW7_1	151:156	LTPGTT	FBXW7	0.9594	More...