DegronMD - Q9UKT9(IKZF3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.G54A	TCGA-19-1790	GBM	TCGA	NVDSGE	DEG_Kelch_Keap1_1	39:44	Mutation rewiring degron network	0.0556
p.G54A	DO12328	GBM	ICGC	NVDSGE	DEG_Kelch_Keap1_1	39:44	Mutation rewiring degron network	0.0556
p.H35D	TCGA-73-4658	LUAD	TCGA	NVDSGE	DEG_Kelch_Keap1_1	39:44	Mutation rewiring degron network	0.2222
p.H35D	DO23663	LUAD	ICGC	NVDSGE	DEG_Kelch_Keap1_1	39:44	Mutation rewiring degron network	0.2222
p.E49K	TCGA-AA-3851	COAD	TCGA	NVDSGE	DEG_Kelch_Keap1_1	39:44	Mutation rewiring degron network	0.1944
p.E49K	DO9972	COAD	ICGC	NVDSGE	DEG_Kelch_Keap1_1	39:44	Mutation rewiring degron network	0.1944
p.A47V	TCGA-CS-5390	LGG	TCGA	NVDSGE	DEG_Kelch_Keap1_1	39:44	Mutation rewiring degron network	0.25
p.A47V	DO22688	LGG	ICGC	NVDSGE	DEG_Kelch_Keap1_1	39:44	Mutation rewiring degron network	0.25
p.A47D	DO229025	LICA	ICGC	NVDSGE	DEG_Kelch_Keap1_1	39:44	Mutation rewiring degron network	0.25
p.D50H	SIDM00528	Breast Carcinoma	GDSC	NVDSGE	DEG_Kelch_Keap1_1	39:44	Mutation rewiring degron network	0.1667
p.D50H	MDA-MB-361	breast	COSMIC	NVDSGE	DEG_Kelch_Keap1_1	39:44	Mutation rewiring degron network	0.1667

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons